No Way to Say Goodbye

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Julian Hanna reviews Stefany Anne Golberg and Morgan Meis's Dead People in 3:AM Magazine:

What makes a life noteworthy and important? What makes a good life? And when a life ends, what constitutes a good summing up, a worthy eulogy? How can a writer, pressed for time, do justice to a life – a great life, presumably – within the hackneyed confines of a two-page obituary? How does one attempt to revive such a dead form?

Or if not dead, then at least resting – unsung, taken for granted – like the manifesto before Marx and Marinetti, when it meant simply a straightforward declaration of intent, no “spectre haunting Europe”, no “courage, audacity, and revolt”. The standard obituary form is: so-and-so was born, rose (usually struggled) to greatness, and died. There is almost a sense that words fail in the face of death, so it is best just to state the facts. How do you breathe life into such a predictable story?

In Dead People, Stefany Anne Golberg and Morgan Meis show us one approach to reinvigorating the form. The collection of twenty-nine obituaries has a provocative cover that makes it great fun to read on the metro. It was written mainly for The Smart Set over the past decade (there are exceptions drawn from n+1 and The New Yorker), and the almost single venue contributes to the high degree of intimacy present in the telling of each life. The authors strike a tone of late-night candour, loose and flowing in the warm glow of the third or fourth drink. But the easy style belies a deeper engagement, honesty about the subject, and a willingness to deal with difficult themes. “We’ve chosen to take these lives personally”, the authors declare in the preface. What Golberg and Meis achieve for the most part is an effortless distillation, boiling down the essence of a public figure’s achievements. The big idea, the breakthrough, the one thing that makes an indelible mark on the culture – this is what we are shown in each brief life.

More here.

Increasing Support for the War on Yemen Is Obviously Insane

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Daniel Larison in The American Conservative:

The Wall Street Journal publishes another shameless pro-Saudi editorial. This part stood out:

A Saudi air strike last week mistakenly killed civilians at a funeral in Yemen, and the White House is now leaking that Mr. Obama is rethinking U.S. support for the Yemen campaign. But the U.S. has made similar targeting errors in many conflicts, and Saudi bombing won’t get more precise if the U.S. bugs out. The U.S. ought to be helping the Saudis with enough support that they can win in Yemen.

Even by the WSJ‘s standards, this is an insane position to take. The funeral massacre last week was obviously not carried out by “mistake.” The coalition repeatedly hit the same target to maximize casualties, and it chose the target because many high-ranking political and military figures were in attendance. The coalition wanted to hit the target, and it did so several times in a row. They weren’t concerned about the hundreds of civilians killed and injured in the process, and it is absurd to claim that they were. When presented with an obvious atrocity committed by a U.S. client, the WSJ predictably ignores the evidence and insists on even more aggressive support for the offending government.

There is also no realistic prospect of a Saudi victory in Yemen. The coalition’s original goals were to drive the Houthis out of the capital and reinstate Hadi. Even if the coalition could somehow manage to do the former, it would come at an excruciating cost for the civilian population. The latter goal has always been hopeless. Hadi had scant domestic support when the war began, and now he has none. There is no chance that the coalition can “win,” and so it makes absolutely no sense for the U.S. to increase support for the war in the hopes that they do. Yemen has been wrecked and its people brought to the brink of famine because of the foolish belief that the Saudis could “win.”

More here.

Freedom from food

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Nicola Twilley in Aeon:

Readers of Hacker News, a website popular with programmers and tech entrepreneurs, were the first to latch on to Rhinehart’s Soylent post, encouraging him to share the recipe online. When he did, it quickly spawned an animated Reddit thread in which DIY Soylent adopters reviewed recipes, discussed magnesium sourcing, and compared bowel movements. Within three months, Rhinehart decided that demand was sufficient for him to quit his tech start-up and form his own company in order to supply Soylent to the masses. By the time Soylent 1.0 started shipping in May 2014, the company had already accumulated a backlog of more than 20,000 pre-orders, adding up to more than $2 million dollars in sales and – at a conservative estimate – a collective saving of 2,875 years.

hat, one wonders, are people doing with all this extra time? Will we see a new Renaissance: a Soylent-fuelled flowering of novels, art or, at the very least, apps? It is perhaps too early to tell, but early signs are mixed. Rhinehart has ploughed his 90 minutes a day into launching his company, and says he still has ‘a long reading list, a long online course list, a lot of personal projects I’d like to do’. He is not against using the time for relaxation, of course, and tells me that he’s heard from other early adopters that they spend an extra hour and a half watching TV, hanging out with friends and family, or just catching up on our pervasive national sleep deficit.

‘Just giving people a little more time in general is something the United States really needs,’ he told me. ‘However you use that time is up to you.’

My own experience bodes less well. I lived on Soylent for five days (Rhinehart sent me a week’s supply, but I cracked early) and I was indeed painfully aware of vast open periods that I would have typically spent planning, shopping for, making, enjoying and cleaning up after meals. Much to my editor’s disappointment, I spent all that extra time joylessly clicking around on the internet, my brain resisting every effort to corral it into more productive activities as if it knew it was being cheated of an expected break. (My editor kindly pointed out that this might be more of a reflection of my own personal failings than a shortcoming inherent to Soylent.)

Of course, this is not the first time Americans have been promised relief from the time-suck of food preparation. Today’s Soylent craze has its roots in the post-Second World War embrace of convenience foods. And, then as now, the range of possible uses for that saved time ranged from the trivial to the substantial – but with a much more gendered twist.

More here.

Saturday, October 15, 2016

How does Ian McEwan pull off Hamlet told by a fetus in ‘Nutshell’?

David Treuer in the Los Angeles Times:

ScreenHunter_2302 Oct. 15 21.54Thesis: The idea behind Ian McEwan’s new novel, “Nutshell”— an imagining of the events leading up to “Hamlet” (Gertrude and Claudius plotting to and then going ahead with killing King Hamlet) set in modern London, with the three principal parts played by John and Trudy and Claude (poet, trophy wife and scheming real estate-dealing brother, respectively) and narrated by Trudy and John’s unborn child in utero — is quite possibly the worst idea for a novel ever.

Antithesis: In McEwan’s hands, the hugely improbable feat of convincingly narrating a novel in the first person from the point of view of a fetus comes alive because McEwan is such a good writer, someone who drives his prose toward the impossible (and has done so throughout his career) in ways that continue to surprise. And a fetus is the perfect spokesling for the as-of-yet-unexplored terrain leading up the bloodbath that is “Hamlet”: How can two people, both of whom must have loved another, conspire to kill another (a spouse), get away with it, and then how do they suffer for what their imaginations made them do? This is the stuff of very good literature.

Discussion: The novel (McEwan’s 17th book) begins with the unnamed fetus uncomfortably crammed in his mother’s uterus some weeks before his inevitable eviction in a state of agitated suspension. Nabokov observed that many novels lurch forward because of eavesdropping (young Marcel spies on the music teacher’s daughter Mademoiselle Vinteuil during a lesbian frolic; the hedges and closets and hallways and fountains of mountain spas are constructed, it seems, to provide Lermontov’s characters with ways of knowing that which they shouldn’t or can’t otherwise). What better place to eavesdrop on a dastardly plot than from the comfort of someone’s womb? That’s what the fetus does from the start: He wombdrops on his mother and her boyfriend as they discuss the fetus’ father, John.

More here.

Where Does Our Arrow Of Time Come From?

Ethan Siegel in Forbes:

ScreenHunter_2301 Oct. 15 21.23Every moment that passes finds us traveling from the past to the present and into the future, with time always flowing in the same direction. At no point does it ever appear to either stand still or reverse; the “arrow of time” always points forwards for us. But if we look at the laws of physics — from Newton to Einstein, from Maxwell to Bohr, from Dirac to Feynman — they appear to be time-symmetric. In other words, the equations that govern reality don’t have a preference for which way time flows. The solutions that describe the behavior of any system obeying the laws of physics, as we understand them, are just as valid for time flowing into the past as they are for time flowing into the future. Yet we know from experience that time only flows one way: forwards. So where does the arrow of time come from?

Many people believe there might be a connection between the arrow of time and a quantity called entropy. While most people normally equate “disorder” with entropy, that’s a pretty lazy description that also isn’t particularly accurate. Instead, think about entropy as a measure of how much thermal (heat) energy could possibly be turned into useful, mechanical work. If you have a lot of this energy capable of potentially doing work, you have a low-entropy system, whereas if you have very little, you have a high-entropy system. The second law of thermodynamics is a very important relation in physics, and it states that the entropy of a closed (self-contained) system can only increase or stay the same over time; it can never go down. In other words, over time, the entropy of the entire Universe must increase. It’s the only law of physics that appears to have a preferred direction for time.

More here.

Future Sex Author, Emily Witt, on Female Sexuality in a Post-Internet World

Julia Felsenthal in Vanity Fair:

ScreenHunter_2300 Oct. 15 21.09At the beginning of Future Sex, Emily Witt’s probing investigation into 21st-century female sexuality, the author is single, 30, and not thrilled about it. She occasionally has sex with men she knows, friends, and friends of friends, casual entanglements that she dismisses as distractions. She and her partners are “souls flitting through limbo, piling up against one another like dried leaves, awaiting the brass trumpets and wedding bells of the eschaton.” Witt feels keenly that she’s missing out on the kind of committed monogamous partnership that had always seemed part and parcel of adulthood, reward for a life of rules followed. “I nurtured my idea of the future,” she writes, “which I thought of as the default denouement of my sexuality, and a destiny rather than a choice. The vision remained suspended, jewel-like in my mind, impervious to the storms of actual experience, a crystalline point of arrival.”

By the book’s end, Witt is several years older and in a different headspace. “I now understood the fabrication of my sexuality,” she writes, “I saw the seams of its construction and the arbitrary nature of its myth.” Her circumstances aren’t markedly changed; the evolution is psychic and semantic. “I knew,” she writes, “that naming sexual freedom as an ideal put the story I told myself about my life in greater alignment with the choices I had already made. It offered continuity between my past and the future. It gave value to experiences that I had viewed with frustration or regret.”

It’s a subtle shift, but the experiences that catalyze it are not so subtle. Future Sex, as the title suggests, takes Witt to the furthest extremes of the erotic vanguard on a quest to establish the contours of her own sexuality, and of female sexuality more generally, in an age of Internet dating and abundant, diverse pornography, of delayed reproduction and more open relationships.

More here.

The Provocative Life of Judge Richard Posner

John Fabian Witt in the New York Times:

ScreenHunter_2299 Oct. 15 20.41Once in every great while, nature and nurture combine in a single person the qualities of erratic genius, herculean work ethic and irrepressible ambition. Think of Picasso in art, Ali in boxing or Roth in literature. Add a penchant for provocation untethered to the constraints of conventional human interaction and you get, in the law, Judge Richard Posner of the United States Court of Appeals for the Seventh Circuit in Chicago.

In the past half-century there has been no figure more dominant or more controversial in American law than Posner. He has written more than 50 books, over 500 articles and nearly 3,000 majority opinions for his court. Not even Supreme Court Justice Oliver Wendell Holmes Jr. — to whom he is often compared — matches his productivity and range.

William Domnarski’s biography, the first such book on Posner, draws on extensive interviews and on access to Posner’s correspondence at the University of Chicago. “Richard Posner” portrays a man who aims self-­consciously to be (in his words) a “Promethean intellectual hero,” remaking the world of the law by sheer will. The questions Domnarski asks are, What makes this extraordinary character tick — and to what end?

More here.

Saturday Poem

The woman is about hair
gathering on the ground and between the breasts
that move up and down with each breath
in suffering.
In twenty years I will exist.
Even if i’m dead in twenty years I will exist
more than I do now.
I shave my legs in the shower
until my ass goes numb.
The water gathers all of me around
and says “that’s what you get”
the same way men say
“that’s just how the world works”
as if they’re happy about it.
I make a prayer for you in front of the closet mirror
where the light from inside moves
around the room to see itself reflected.
The woman sees herself in everything and nothing.
You can open the news and read
anything you want to.
That’s the magic of being alive here.
You can even read about yourself
long after you’re dead.
.

Joshua Jennifer Espinoza
from Feminist Wire, July 2015

‘Messy’ Proposes a Flexible Approach to Life

Maria Konnikova in The New York Times:

BookIn 1993, a few years after the success of his firm’s ad campaign that introduced the Apple Mac, the head of the Chiat/Day agency, Jay Chiat, decided that it was time to have a workplace that matched the verve of the agency’s advertising. In Los Angeles, he commissioned Frank Gehry to create a place that was “playful, zany and stylish”: no cubicles, no offices, no traditional desks. Space was filled with a four-story statue of a pair of binoculars and pods from old fairground rides where “people would sit together . . . and think creative thoughts.” In New York, Chiat tasked Gaetano Pesce with much the same vision, resulting in murals of red lips, chairs with springs for feet and a floor in front of a bathroom that would raise many an eyebrow in today’s trigger-warning culture (a picture of a man urinating). When Frank Duffy, an architect who is no stranger to innovation in office design himself (he is credited as a founder of Bürolandschaft, the office-landscaping movement), saw the project, he said, “Perhaps its gravest weakness is that it is a place where ‘play’ is enforced on everyone, all the time.”

That statement is at the heart of “Messy: The Power of Disorder to Transform Our Lives,” the latest book from the economist-turned-journalist Tim Harford. At first, it seems an odd comment to include. After all, isn’t the Chiat/Day approach the quintessence of mess — disrupting the staid old office style, pivoting in a new creative direction, or any of those other business clichés? But it’s actually perfect. Because the mess Harford has in mind is less physical than psychical. It’s not that disruption is inherently good, or that we should strive actually to be messy — unconstrained by desks or real work spaces, free to roam and think, surrounded by playful towers of stuff in stubborn defiance of Kondo-ization. It’s that rigid rules are bad, whether they err on the side of too much mess or too little. Rigidity disempowers people. In telling us to be messy, Harford urges us to recapture our autonomy. A less catchy, but perhaps more accurate, title for the book would be “Control: The Power of Autonomy and Flexibility.”

More here.

Friday, October 14, 2016

Slavoj Žižek: Clown Prince of the Revolution

Roger Scruton in City Journal:

ScreenHunter_2298 Oct. 15 11.17During the 1960s and 1970s, the consensus in Western academic and intellectual institutions was very much on the left. Writers like Michel Foucault and Pierre Bourdieu shot to eminence by attacking the civilization they dismissed as “bourgeois.” The critical-theory writings of Jürgen Habermas achieved a dominant place in the curriculum in the social sciences, despite their stupefying tediousness. The rewriting of national history as a tale of “class struggle,” undertaken by Eric Hobsbawm in Britain and Howard Zinn in the United States, became a near-orthodoxy not only in university history departments but also in high schools. For us dissidents, it was a dispiriting time, and there was scarcely a morning when I did not wake up during those years, asking myself whether my teaching at the University of London was the right choice of career. Then came the collapse of Communism in Eastern Europe, and I allowed myself to hope.

For a while, it looked as though an apology might be forthcoming from those who had devoted their intellectual and political efforts to whitewashing the crimes of the Soviet Union or praising the “people’s republics” of China and Vietnam. But the moment proved short-lived. Within a decade, the Left establishment was back in the driver’s seat, with Zinn and Noam Chomsky renewing their intemperate denunciations of America, the European Left regrouped against “neoliberalism” (the new name for the free economy) as though this had been the trouble all along, Habermas and Ronald Dworkin collecting prestigious prizes for their barely readable defenses of ruling leftist platitudes, and the veteran Marxist Hobsbawm rewarded for a lifetime of unswerving loyalty to the Soviet Union by his appointment as “Companion of Honour” to the Queen.

True, the enemy was no longer described as before: the Marxist template did not easily fit the new conditions, and it seemed a trifle foolish to champion the cause of the working class, when its last members were joining the ranks of the unemployable or the self-employed. But one thing remained unchanged in the wake of Communism’s collapse: the conviction that it was unacceptable to be on the “right.”

More here.

Black Panther Primer

Jay A. Fernandez in Signature:

ScreenHunter_2297 Oct. 15 11.05African Americans’ struggle for equality in America has taken on many shapes and strategies since the Thirteenth Amendment, which officially abolished slavery, was ratified in 1865. From the Niagara Movement and the formation of the NAACP through Marcus Garvey’s Universal Negro Improvement Association to the powerful oratory and organization of Malcolm X and Martin Luther King Jr.; from the fiery poetry and literature of Richard Wright, Nikki Giovanni, James Baldwin, and Amiri Baraka to the Million Man March and Black Lives Matter, the great, ongoing effort has been a defining characteristic of the American identity, ever convulsing and changing, if never quickly or comprehensively enough.

Malcolm X was killed in early 1965, and King in April 1968. In between, fifty years ago on October 15 in Oakland, former college classmates Bobby Seale and Huey P. Newton, inspired by the forceful rhetoric of the former and disillusioned by the nonviolent approach of the latter, formed the Black Panther Party for Self-Defense. While contentious from the start, and dogged by both internal criminal tendencies and outside government forces seeking to discredit the group as a threat to democracy, the Panthers undeniably hold a key place in the history of the black struggle, even if many of their ambitiously broad aims, which included standing up to police brutality and the unpunished killings of unarmed black civilians, remain sadly unrealized half a century later. (The group dissolved in 1982.)

More here.

LISTENING TO PHILOSOPHY, SILENCE & SELF: in conversation with Jean-Luc Nancy

From IIIIXIII Magazine:

ScreenHunter_2296 Oct. 15 10.57The relationship between art and philosophy has a long and troubled history. In his Republic, Plato banished art from his ideal society and invited philosophy to become the sovereign ruler of the state. For Plato, art was a form of illusion, creating a representation of an empirical world that was already one step removed from the truth of his Platonic Ideas. It wasn’t until the the German Idealists, and the work of Georg Wilhelm Friedrich Hegel in particular, that art and philosophy came closer to harmony. For Hegel, art too was an expression of truth, albeit in a sensuous and thereby imperfect form.

Jean-Luc Nancy is a French philosopher, who has written works on thinkers from Georg Wilhelm Friedrich Hegel, to Immanuel Kant, René Descartes and Martin Heidegger. Throughout his work, he has challenged and questioned philosophy’s denigration of the sensuous and its privileging of the concept. He first came to prominence with The Inoperative Community (1991) and some of his other most well known work include, The Sense of the World (1993) and Being Singular Plural (2000), which highlights the question of our being together in contemporary society as one of the main themes in his prolific work. Nancy has also published books on film, literature and music, such as on the work of Abbas Kiarostami, On Kawara, Charles Baudelaire and Friedrich Hölderlin.

We talked to Jean-Luc Nancy about the relations of philosophy, art, silence and the self.

More here.

India’s Eternal Inequality

Aatish Taseer in the New York Times:

13Taseer-blog427It is one thing to have a theoretical knowledge of caste. It is quite another to see it in action. A few months ago, I was given a small, relatively benign glimpse into how this idea of spiritual purity actually affects people’s lives inIndia.

I was in Varanasi, India’s most sacred city, conducting research for a book about Brahmins, the priestly caste at the top of the Hindu hierarchy. I was speaking at length to a young student who, like his Brahmin ancestors, was steeped in the study of Sanskrit and the Veda. One day, we drove together to the village where he came from. Our driver on this five-hour journey was a voluble man from the neighboring state of Bihar. Along the way, the driver, the student and I chatted amicably, but as we neared the Brahmin village, our dynamics swiftly changed.

My father was Muslim, and since religion in India is patrilineal, my presence in the Brahmin household should have been an unspeakable defilement. But it wasn’t. I belong to India’s English-speaking upper class and, in the eyes of my host, I was exempt from the rules of caste. As we approached the village, he did make one small adjustment: He stopped calling me by my conspicuously Muslim name, and rechristened me Nitish, a Hindu name.

More here.

How Vector Space Mathematics Helps Machines Spot Sarcasm

From the MIT Technology Review:

SarcasmBack in 1970, the social activist Irina Dunn scribbled a slogan on the back of a toilet cubicle door at the University of Sydney. It said: “A woman needs a man like a fish needs a bicycle.” The phrase went viral and eventually became a famous refrain for the growing feminist movement of the time.

The phrase is also an example of sarcasm. The humor comes from the fact that a fish doesn’t need a bicycle. Most humans have little trouble spotting this. But while various advanced machine learning techniques have helped computers spot other forms of humor, sarcasm still largely eludes them.

These other forms of humor can be spotted by looking for, say, positive verbs associated with negative or undesirable situation. And some researchers have used this approach to look for sarcasm.

But sarcasm is often devoid of sentiment. The phrase above is a good example—it contains no sentiment-bearing words. So a new strategy is clearly needed if computers are ever to spot this kind of joke.

More here.

Friday Poem

And Ut Pictura Poesis Is Her Name

You can’t say it that way any more.
Bothered about beauty you have to
Come out into the open, into a clearing,
And rest. Certainly whatever funny happens to you
Is OK. To demand more than this would be strange
Of you, you who have so many lovers,
People who look up to you and are willing
To do things for you, but you think
It’s not right, that if they really knew you . . .
So much for self-analysis. Now,
About what to put in your poem-painting:
Flowers are always nice, particularly delphinium.
Names of boys you once knew and their sleds,
Skyrockets are good—do they still exist?
There are a lot of other things of the same quality
As those I’ve mentioned. Now one must
Find a few important words, and a lot of low-keyed,
Dull-sounding ones. She approached me
About buying her desk. Suddenly the street was
Bananas and the clangor of Japanese instruments.
Humdrum testaments were scattered around. His head
Locked into mine. We were a seesaw. Something
Ought to be written about how this affects
You when you write poetry:
The extreme austerity of an almost empty mind
Colliding with the lush, Rousseau-like foliage of its desire to communicate
Something between breaths, if only for the sake
Of others and their desire to understand you and desert you
For other centers of communication, so that understanding
May begin, and in doing so be undone.
.

by John Ashbery
from Houseboat Days
Farrar Straus and Giroux, 1987

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Why Bob Dylan’s Nobel Prize for Literature is long overdue

Liz Thomson in New Statesman:

DylanI was too young to appreciate the arrival of Bob Dylan. My generation screamed for the pop music pin-ups of the Seventies such as the Osmonds and David Cassidy. It wasn’t until 1976, when he released his bestselling album, Desire, that Dylan's growly tones first caught my imaginationI. His former girlfriend, the folk singer Joan Baez, was my entrée: I learned to play guitar from her records on which I first encountered such magisterial Dylan songs as “A Hard Rain’s a-Gonna Fall” and “With God on Our Side”, which I never did master. I knew “Blowin’ in the Wind” of course: written in 1963 and a hit for the group Peter, Paul and Mary first, it was already part of our cultural DNA, so too was the 1965 hit single “Mr Tambourine Man”. Soon I would discover songs such as “The Times They Are a-Changin’” and “Like a Rolling Stone” whose lyrics are now part of our lingua franca, paraphrased by headline writers around the world.

The man who was born Robert Allen Zimmerman in Duluth, Minnesota was today awarded the Nobel Prize for Literature. Some will carp (why not Philip Roth or Salman Rushdie, or Alice Waters?), but most will agree it is an honour long overdue —and perhaps fitting that it be awarded now, in his seventy-fifth year. That his best work is behind him matters not. His last truly great album was in 1975, Blood on the Tracks, its songs full of the pain of divorce. There have been flashes of brilliance since (Oh, Mercy, 1989; Time Out of Mind, 1997) but none compares to the genius (a word not used lightly) of the handful of albums Dylan made between his debut in 1962 and the motorcycle crash of July 1966 that allowed him to escape the drug-fuelled craziness and retreat to his lie low at his home in Woodstock.

More here.

Safety Concerns Blight Promising Cancer Therapy

Heidi Ledford in Scientific American:

StatA groundbreaking treatment that arms immune cells called T cells to battle cancer is barrelling towards regulators, fuelled by unprecedented clinical success and investor exuberance. But progress of the therapy, called CAR-T, has been marred by its toxicity; several deaths have been reported in clinical trials. Even as the first company readies its application to the US Food and Drug Administration (FDA)—expected by the end of the year—researchers are hard at work to make the supercharged T cells safer. Doing so is crucial to expanding the use of the therapy to more people, says Anthony Walker, a managing partner at Alacrita, a consulting firm in London. “Right now it is heroic medicine,” he says—a gruelling treatment deployed only in people for whom all else has failed. “Patients are taken sometimes to within an inch of their lives.”

Most CAR-T procedures begin by harvesting a patient’s white blood cells and sifting out the T cells. Those T cells are engineered to recognize cancer cells, and then infused into the patient, ready to do battle. The approach has shown remarkable success against leukaemias and lymphomas: in one study, all traces of leukaemia disappeared in 90% of the patients who received the treatment (S. L. Maude et al. N. Engl. J. Med. 371, 1507–1517; 2014). Results such as those have fuelled an investor frenzy. “It set the field on fire,” says Walker. Swiss pharmaceutical giant Novartis invested in the technique in 2012. In 2014, CAR-T firm Kite Pharma of Santa Monica, California, raised US$128 million when it went public. A few months later, one of its competitors, Juno Therapeutics of Seattle, Washington, yielded $264 million in its initial public offering. Now Kite is racing to be the first to bring a CAR-T therapy to the market. On October 18, the company will update investors on its plans to manufacture and sell the complex therapy, which it hopes to launch in 2017. But the treatment’s toxicity has discouraged some investors. On September 26, Kite released interim clinical-trial results—widely seen as successful—in people with aggressive non-Hodgkin’s lymphoma (see go.nature.com/2djdqen). Yet about one-third of the patients developed serious neurological side effects, and 18% developed a deadly condition called cytokine release syndrome, which can cause organ failure. Two of the 62 patients died as a result of the treatment.

More here.

Thursday, October 13, 2016

On the Bombing of Aleppo

George Soros in the New York Review of Books:

ScreenHunter_2293 Oct. 13 18.21The world is witnessing a humanitarian catastrophe of historic proportions. It is happening in Syria. It is being perpetrated by the president of Russia, Vladimir Putin, in support of his protégé, Bashar al-Assad. Russian planes are bombing the civilian population of Aleppo, the country’s second-largest city, to assist Syrian government forces that are attempting to take control of rebel-held areas of the city.

The combined assault has, among other things, killed hundreds of people and wounded over a thousand, put the city’s remaining hospitals out of commission, and deprived the population of drinking water.

President Putin is moving aggressively to exploit the three months between now and the January 20 US presidential inauguration, based on a callous political calculation.

As The New York Times puts it:

Mr. Putin calculates that the departing President Obama will be unlikely to intervene in the escalating Syrian conflict and a new American president who might consider a tougher policy will not yet be in office. “Putin is in a hurry before the American elections,” said Nikolai V. Petrov, a political scientist in Moscow. “The next American president will face a new reality and will be forced to accept it.”

Other articles in The New York Times and elsewhere have vividly depicted the suffering of the people of Aleppo and the heroic efforts of the doctors and civilians like White Helmets who are risking their lives to help them. When the facts are fully established, Putin’s bombing of Aleppo will be viewed as among the modern world’s most egregious war crimes.

More here.