If Solar And Wind Are So Cheap, Why Are They Making Electricity So Expensive?

Michael Shellenberger in Forbes:

LalaOver the last year, the media have published story after story after story about the declining price of solar panels and wind turbines.

People who read these stories are understandably left with the impression that the more solar and wind energy we produce, the lower electricity prices will become.

And yet that’s not what’s happening. In fact, it’s the opposite.

Between 2009 and 2017, the price of solar panels per watt declined by 75 percent while the price of wind turbines per watt declined by 50 percent.

And yet — during the same period — the price of electricity in places that deployed significant quantities of renewables increased dramatically.

Electricity prices increased by:

51 percent in Germany during its expansion of solar and wind energy from 2006 to 2016;

24 percent in California during its solar energy build-out from 2011 to 2017;

over 100 percent in Denmark since 1995 when it began deploying renewables (mostly wind) in earnest.

What gives? If solar panels and wind turbines became so much cheaper, why did the price of electricity rise instead of decline?

More here.

The Iran Regime-Change Crew Is Back

Vali Nasr in The Atlantic:

Lead_960_540 (5)Among the most strident critics of the nuclear deal with Iran are those who believe it furthers the survival of its leadership. By throwing Iran’s rulers an economic lifeline, they believe, the deal is an abject failure. America’s goal, they say, should never have been “denuclearization,” but regime change.

These days, those regime-change evangelists, having shrugged off the lessons of the Iraq War, are back at the helm of U.S. foreign policy. John Bolton, Donald Trump’s new national-security adviser, has long advocated regime change in Iran, and more recently has argued that the administration should openly embrace it as a foreign-policy goal. At the same time, Bolton and his ilk are pushing for a denuclearization deal with North Korea ahead of Trump’s planned summit with Kim Jong Un, the country’s leader. Preparations for the meeting will likely be in full swing by May 12, the next deadline for extending the Iran deal. The Trump administration, in other words, could find itself in the odd situation of tearing down the nuclear deal with Iran while pursuing a similar deal with North Korea.

With proponents of regime change ascendant, the temptation in the Trump administration to cast the deal aside in an effort to weaken Iran is great. Yet the immediate ripple effects of such a decision will breed dangerous consequences, both in Iran and across the Middle East—ones that the Kim regime will be watching carefully.

More here.

DO WE EVEN NEED MEN?

John Launer in Literary Hub:

8-groomsmen-silhouette-clipart-4Why do males exist? If you learned biology at school, your teachers will probably have told you it was because combining genes from different individuals—one male and one female—increases variation in a species, and it is variation that helps a species survive.

Unfortunately, most evolutionary experts stopped believing in this explanation over 30 years ago. From a reproductive point of view, no individual is interested in anything very much beyond donating genes to the next generation. As far as whole species are concerned, they are preserved or wiped out more or less at random, largely according to the whims of climate and geology. In addition, you don’t actually need sexes to produce variation: the vast majority of organisms like microbes happily mutate and vary withoutsex.

The great evolutionist John Maynard Smith regarded sex as more or less inexplicable. He talked of “the twofold cost of males.” First, it is incomprehensible that any female should want to throw away half her genes and take on someone else’s, when theoretically she could just produce clones of herself instead. Secondly, the males of many species are entirely useless at doing anything except sitting around, getting fat at the females’ expense, and—in the words of Richard Dawkins—duffing up other males. Among some animals, such as elephant seals, the vast majority of males die as wasteful, disappointed virgins.

Given this wastefulness, it is perhaps not surprising that there are at least 40 species where the female kills the male during or after sex.

More here.

Garry Winogrand’s Photographs Contain Entire Novels

Garry-Winogrand-1Geoff Dyer at Literary Hub:

Already, by 1960, Garry Winogrand was taking pictures that didn’t make any sense. Even now, we struggle to get a handle on them, but back then, before the pictures had altered the grammar of photography sufficiently to enable us to get to grips with them . . .

The amount of information in the photograph below is considerable but the ordering of it so minimal—or discreet, at any rate—it’s difficult to know how to process it. How many lives are being actively lived in this picture? What is happening? What are we looking at? For one thing, we’re looking at a manifestation or projection of our own confusion in the form of the guy scratching his head, a gesture that might for him be purely mechanical (an itch?) but which here becomes imbued with psychological and existential weight because he is asking the question we are asking: What is going on here? So the person asking this question becomes the key to the riddle of which he is a central part.

This key turns out to be compositional even though, back in 1960, it seemed to many that Winogrand had given composition the elbow—in this instance, quite literally. The elbow is the element on which the whole picture hinges. The head-scratcher’s elbow links arms, as it were, with those of the other walkers—especially the woman in the white dress, behind him and to his left—which leads, in turn, to those of the woman in the black dress, the diagonal straps of which mirror the triangulation of upper and lower arm hinged at the elbow.

more here.

The Dark Side of Nice

AmericannicenessD. Berton Emerson at the LARB:

If meanness is one reason it seems almost impossible to talk to each other across our current political divide, niceness is another. For the vulnerable and the threatened, being nice is not an option, for their lives are on the line. Yet too many Americans retreat behind the no-contest zone of niceness, and prefer not to even try. And this is why Bramen’s book is so important right now: American Niceness does a remarkable job of demonstrating not only the history of deeply entrenched norms of niceness but also the reasons they have lurked beneath our critical radar for so long. Bramen shows impressive range in her analysis, tracking the development of American niceness back to the earliest myths of settler colonialism on the New England shore and forward through the pre–Civil War decades all the way to foreign policy at the turn of the century. It’s an outstanding scholarly book: well researched, well written, and methodologically innovative. I also found it to be incredibly frustrating, because it so aptly demonstrates the embeddedness and pervasiveness of a quality that is both the greatest generator and the greatest inhibitor of positive change. Turns out, American niceness is a real motherfucker.

more here.

Kurt Gödel and the mechanization of mathematics

Kurt-GodelJuliette Kennedy at the TLS:

Mathematics springs from creative acts of the human imagination; yet at the same time the creativity of the mathematician is constrained by the fact of the matter. It is not up to the mathematician whether there are infinitely many prime numbers – either there are or there aren’t, and thanks to one of Euclid’s theorems, we know that there are; in fact, it is even provable.

About provability, much is known. For example, many mathematical proofs can be mechanized, that is, checked by a computer. In fact, one could imagine a completely automated practice, where one could theoretically build, say, a Turing Machine, into which one could input any mathematical conjecture and the machine would output a definite answer, yes or no, or true or false, in a finite amount of time.

One way of describing the Incompleteness Theorems (1931) of the Austrian logician Kurt Gödel is to say that he proved, in the form of a mathematical theorem, that the possibility of a fully automated mathematics can never be realized.

more here.

How Poetry and Math Intersect

Evelyn Lamb in Smithsonian:

April is both National Poetry Month and Mathematics and Statistics Awareness Month, so a few years ago science writer Stephen Ornes dubbed it Math Poetry Month. If the words “math” and “poetry” don’t intuitively make sense to you as a pair, poet and mathematician JoAnne Growney’s blog Intersections—Poetry with Mathematics is a perfect place to start expanding your math-poetic horizons. The blog includes a broad range of poems with mathematical themes or built using mathematical rules. Take “Geometry,” by former U.S. Poet Laureate Rita Dove:

I prove a theorem and the house expands:
the windows jerk free to hover near the ceiling,
the ceiling floats away with a sigh.

—from “Geometry” by Rita Dove

…Growney grew up wanting to be a writer. “I read Little Women as a girl, and maybe it was partly the name connection, but I thought that I wanted to be a writer like Jo.” She was also good at math, though, and ended up with a scholarship to study it in college. She stuck with it and earned her Ph.D. in 1970 at the University of Oklahoma. During her career as a math professor, her interest in writing continued. She took poetry classes at a nearby college when she could, discovered the math poetry anthology Against Infinity while doing a sabbatical project about mathematics and the arts, and started to see her feelings about mathematics echoed in poetry. Mathematics and poetry, Growney says, are both “formats that can convey multiple meanings.” In mathematics, a single object or idea might take different forms. A quadratic equation, for example, can be understood in terms of its algebraic expression, perhaps y=x2+3x-7, or in terms of its graph, a parabola. Henri Poincaré, a French polymath who laid the foundations of two different fields of mathematics in the early 1900s, described mathematics as “the art of giving the same name to different things.”

More here.

How Poetry and Math Intersect

Evelyn Lamb in Smithsonian:

PoetryApril is both National Poetry Month and Mathematics and Statistics Awareness Month, so a few years ago science writer Stephen Ornes dubbed it Math Poetry Month. If the words “math” and “poetry” don’t intuitively make sense to you as a pair, poet and mathematician JoAnne Growney’s blog Intersections—Poetry with Mathematics is a perfect place to start expanding your math-poetic horizons. The blog includes a broad range of poems with mathematical themes or built using mathematical rules. Take “Geometry,” by former U.S. Poet Laureate Rita Dove:

I prove a theorem and the house expands:
the windows jerk free to hover near the ceiling,
the ceiling floats away with a sigh.

—from “Geometry” by Rita Dove

…Growney grew up wanting to be a writer. “I read Little Women as a girl, and maybe it was partly the name connection, but I thought that I wanted to be a writer like Jo.” She was also good at math, though, and ended up with a scholarship to study it in college. She stuck with it and earned her Ph.D. in 1970 at the University of Oklahoma. During her career as a math professor, her interest in writing continued. She took poetry classes at a nearby college when she could, discovered the math poetry anthology Against Infinity while doing a sabbatical project about mathematics and the arts, and started to see her feelings about mathematics echoed in poetry. Mathematics and poetry, Growney says, are both “formats that can convey multiple meanings.” In mathematics, a single object or idea might take different forms. A quadratic equation, for example, can be understood in terms of its algebraic expression, perhaps y=x2+3x-7, or in terms of its graph, a parabola. Henri Poincaré, a French polymath who laid the foundations of two different fields of mathematics in the early 1900s, described mathematics as “the art of giving the same name to different things.”

More here.

Thursday Poem

For My Father Gazing at the World After His Mother Died

If I said anything, he’d stop, so I just let him be.
Tell me, I wanted to ask, how
to be parentless & alone & secretly
in love with water. There’s a now

we each live in
that sometimes feels more like never
than enough. If my father believes in ascension,
then out there, beyond the lake, his mother lives forever.

In the lake, too. In the wind to comb my father’s hair.
In the tree that wills each holy & parentless
limb to cast a shadow in the morning sun’s light. Out there,
I hope, all we’ve ever missed

becomes all we ever are. I love. I’ve loved. I will love to keep my
                                                          father alive.
When he turned slow to me, he blamed the wind for all his crying.

by Devin Kelly
from Ecotheo Review
March 2018

Thursday Poem

For My Father Gazing at the World After His Mother Died

If I said anything, he’d stop, so I just let him be.
Tell me, I wanted to ask, how
to be parentless & alone & secretly
in love with water. There’s a now

we each live in
that sometimes feels more like never
than enough. If my father believes in ascension,
then out there, beyond the lake, his mother lives forever.

In the lake, too. In the wind to comb my father’s hair.
In the tree that wills each holy & parentless
limb to cast a shadow in the morning sun’s light. Out there,
I hope, all we’ve ever missed

becomes all we ever are. I love. I’ve loved. I will love to keep my
father alive.
When he turned slow to me, he blamed the wind for all his crying.

by Devin Kelly
from Ecotheo Review
March 2018

Wednesday, April 25, 2018

The only way to construct a robust philosophy for life is to have a clear and realistic picture of what makes humans tick

Skye C Cleary and Massimo Pigliucci in Aeon:

ScreenHunter_3067 Apr. 25 19.38A strange thing is happening in modern philosophy: many philosophers don’t seem to believe that there is such a thing as human nature. What makes this strange is that, not only does the new attitude run counter to much of the history of philosophy, but – despite loud claims to the contrary – it also goes against the findings of modern science. This has serious consequences, ranging from the way in which we see ourselves and our place in the cosmos to what sort of philosophy of life we might adopt. Our aim here is to discuss the issue of human nature in light of contemporary biology, and then explore how the concept might impact everyday living.

The existence of something like a human nature that separates us from the rest of the animal world has often been implied, and sometimes explicitly stated, throughout the history of philosophy. Aristotle thought that the ‘proper function’ of human beings was to think rationally, from which he derived the idea that the highest life available to us is one of contemplation (ie, philosophising) – hardly unexpected from a philosopher. The Epicureans argued that it is a quintessential aspect of human nature that we are happier when we experience pleasure, and especially when we do not experience pain. Thomas Hobbes believed that we need a strong centralised government to keep us in line because our nature would otherwise lead us to live a life that he memorably characterised as ‘solitary, poor, nasty, brutish, and short’. Jean-Jacques Rousseau embedded the idea of a human nature in his conception of the ‘noble savage’. Confucius and Mencius thought that human nature is essentially good, while Hsün Tzu considered it essentially evil.

The keyword here is, of course, ‘essentially’. One of the obvious exceptions to this trend was John Locke, who described the human mind as a ‘tabula rasa’ (blank slate), but his take has been rejected by modern science. As one group of cognitive scientists describes it in From Mating to Mentality (2003), our mind is more like a colouring book, or a ‘graffiti-filled wall of a New York subway station’ than a blank slate.

In contrast, many contemporary philosophers, both of the so-called analytic and continental traditions, seem largely to have rejected the very idea of human nature.

More here.

Artificial Intelligence — The Revolution Hasn’t Happened Yet

Michael Jordan:

1_YryHJzKJy0ZYOWjlS2shMQArtificial Intelligence (AI) is the mantra of the current era. The phrase is intoned by technologists, academicians, journalists and venture capitalists alike. As with many phrases that cross over from technical academic fields into general circulation, there is significant misunderstanding accompanying the use of the phrase. But this is not the classical case of the public not understanding the scientists — here the scientists are often as befuddled as the public. The idea that our era is somehow seeing the emergence of an intelligence in silicon that rivals our own entertains all of us — enthralling us and frightening us in equal measure. And, unfortunately, it distracts us.

There is a different narrative that one can tell about the current era. Consider the following story, which involves humans, computers, data and life-or-death decisions, but where the focus is something other than intelligence-in-silicon fantasies. When my spouse was pregnant 14 years ago, we had an ultrasound. There was a geneticist in the room, and she pointed out some white spots around the heart of the fetus. “Those are markers for Down syndrome,” she noted, “and your risk has now gone up to 1 in 20.” She further let us know that we could learn whether the fetus in fact had the genetic modification underlying Down syndrome via an amniocentesis. But amniocentesis was risky — the risk of killing the fetus during the procedure was roughly 1 in 300. Being a statistician, I determined to find out where these numbers were coming from. To cut a long story short, I discovered that a statistical analysis had been done a decade previously in the UK, where these white spots, which reflect calcium buildup, were indeed established as a predictor of Down syndrome. But I also noticed that the imaging machine used in our test had a few hundred more pixels per square inch than the machine used in the UK study. I went back to tell the geneticist that I believed that the white spots were likely false positives — that they were literally “white noise.” She said “Ah, that explains why we started seeing an uptick in Down syndrome diagnoses a few years ago; it’s when the new machine arrived.”

More here.

A Brand-New Version of Our Origin Story: Jared Diamond on David Reich’s New Book

Jared Diamond in the New York Times:

35749414For over a decade, National Geographic’s Genographic Project has been collecting saliva samples from willing participants, analyzing small pieces of their mother’s and father’s DNA (so-called mitochondrial DNA and Y chromosome DNA, respectively). In return, there is fascinating personal information to be had — about individual ancestries, and about close relatives whose existence had been previously unknown.

But geneticists can now achieve far more than those limited analyses could, and can approach their dream of using genetic evidence to reconstruct past human migrations. One reason is that methods for extracting DNA from bones of ancient humans who lived tens of thousands of years ago have improved. It’s possible now to separate their DNA from all the bacterial and modern human DNA that contaminates those bones. Another reason is that, due especially to the Harvard geneticist David Reich and his colleagues, we now have efficient methods for analyzing whole ancient human genomes, not just the few percent contributed by mitochondrial DNA and the Y chromosome.

In “Who We Are and How We Got Here,” Reich summarizes this rapidly advancing field. He begins with a crash course on genetics and DNA sequencing, then discusses the Neanderthals and “ghost populations” whose existences are inferred from genetic evidence although they no longer exist. Most of the book then consists of chapters reconstructing the histories of modern Europeans, Indians, Native Americans, East Asians and Africans. Concluding chapters probe the controversial subject of race and identity, and prospects for new discoveries. I’ll illustrate Reich’s chapters with three examples: Neanderthals, Europeans and Polynesians.

More here.

Which Feminisms?

Feminism

Susan Watkins in The New Left Review:

Of all the opposition movements to have erupted since 2008, the rebirth of a militant feminism is perhaps the most surprising—not least because feminism as such had never gone away; women’s empowerment has long been a mantra of the global establishment. Yet there were already signs that something new was stirring in the US and UK student protests of 2010, the 2011 Occupy encampments at Puerta del Sol and Zuccotti Park. In India, mass rallies condemned the gang rape of Jyoti Pandey in 2012 and feminist flash-mobs have disrupted the moral-policing operations of Hindutva fundamentalists. The protests against sexual assault on US campuses blazed across the New York media in 2014. In Brazil, 30,000 black women descended on the capital in 2015 to demonstrate against sexual violence and racism, calling for the ouster of the corrupt head of the National Congress, Eduardo Cunha; earlier that year, the March of Margaridas brought over 50,000 rural women to Brasília. In Argentina, feminist campaigners against domestic violence were at the forefront of protests against Macri’s shock therapy. In China, the arrest in 2015 of five young women preparing to sticker Beijing’s public transport against sexual violence—members of Young Feminist Activism, an online coalition that’s played cat-and-mouse with the authorities—was met with web petitions signed by over 2 million people.

In January 2017, a ‘feminism of the 99 per cent’ declared itself with the million-strong march against the Trump Administration in the US. In Poland, mass women’s protests forced the Law and Justice government to retreat from tightening the already restrictive abortion law. Italy, Spain and Portugal saw huge marches against domestic violence and economic precarity. On 8 March 2017, these movements came together to put International Women’s Day back on the radical calendar, with demonstrations and strikes on three continents. The eruption of #MeToo in October 2017 and the convulsions that have followed are only the latest in a string of mass events around the world.

Yet any attempt to renew feminist strategy today confronts a series of dilemmas. First, we lack convincing assessments of the progress already made. What results have the old feminisms produced and how adequate have these been in meeting women’s needs? How, exactly—by what processes, to what extent—have conditions improved? What changes have been brought about, globally, in gender relations, and where do these now stand?

More here.

Wednesday Poem

Coffee

The only precious thing I own, this little espresso
cup. And in it a dark roast all the way
from Honduras, Guatemala, Ethiopia
where coffee was born in the 9th century
getting goat herders high, spinning like dervishes, the white blooms
cresting out of the evergreen plant, Ethiopia
where I almost lived for a moment but
then the rebels surrounded the Capital
so I stayed home. I stayed home and drank
coffee and listened to the radio
and heard how they were getting along. I would walk
down Everett Street, near the hospital
where my older brother was bound
to his white bed like a human mast, where he was
getting his mind right and learning
not to hurt himself. I would walk by and be afraid and smell
the beans being roasted inside the garage
of an old warehouse. It smelled like burnt
toast! It was everywhere in the trees. I couldn’t bear to see him.
I sometimes never knew him. Sometimes
he would call. He wanted us
to sit across from each other, some coffee between us,
sober. Coffee can taste like grapefruit
or caramel, like tobacco, strawberry,
cinnamon, the oils being pushed
out of the grounds and floating to the top of a French Press,
the expensive kind I get
in the mail, the mailman with a pound of Sumatra
under his arm, ringing my doorbell,
waking me up from a night when all I had was tea
and watched a movie about the Queen of England when Spain was hot
for all her castles and all their ships, carved out
of fine Spanish trees, went up in flames
while back home Spaniards were growing potatoes
and coffee was making its careful way
along a giant whip
from Africa to Europe
where cafes would become famous
and people would eventually sit with their cappuccinos, the baristas
talking about the new war, a cup of sugar
on the table, a curled piece of lemon rind. A beret
on someone’s head, a scarf
around their neck. A bomb in a suitcase
left beneath a small table. Right now
I’m sitting near a hospital where psychotropics are being
carried down the hall in a pink cup,
where someone is lying there and he doesn’t know who
he is. I’m listening
to the couple next to me
talk about their cars. I have no idea
how I got here. The world stops at the window
while I take my little spoon and slowly swirl the cream around the lip
of the cup. Once, I had a brother
who used to sit and drink his coffee black, smoke
his cigarettes and be quiet for a moment
before his brain turned its Armadas against him, wanting to burn down
his cities and villages, before grief
became his capital with its one loyal flag and his face,
perhaps only his beautiful left eye, shimmered on the surface of his Americano
like a dark star.
.
by Matthew Dickman
from All-American Poem
Copper Canyon Press, 2008

Wednesday Poem

Coffee

The only precious thing I own, this little espresso
cup. And in it a dark roast all the way
from Honduras, Guatemala, Ethiopia
where coffee was born in the 9th century
getting goat herders high, spinning like dervishes, the white blooms
cresting out of the evergreen plant, Ethiopia
where I almost lived for a moment but
then the rebels surrounded the Capital
so I stayed home. I stayed home and drank
coffee and listened to the radio
and heard how they were getting along. I would walk
down Everett Street, near the hospital
where my older brother was bound
to his white bed like a human mast, where he was
getting his mind right and learning
not to hurt himself. I would walk by and be afraid and smell
the beans being roasted inside the garage
of an old warehouse. It smelled like burnt
toast! It was everywhere in the trees. I couldn’t bear to see him.
I sometimes never knew him. Sometimes
he would call. He wanted us
to sit across from each other, some coffee between us,
sober. Coffee can taste like grapefruit
or caramel, like tobacco, strawberry,
cinnamon, the oils being pushed
out of the grounds and floating to the top of a French Press,
the expensive kind I get
in the mail, the mailman with a pound of Sumatra
under his arm, ringing my doorbell,
waking me up from a night when all I had was tea
and watched a movie about the Queen of England when Spain was hot
for all her castles and all their ships, carved out
of fine Spanish trees, went up in flames
while back home Spaniards were growing potatoes
and coffee was making its careful way
along a giant whip
from Africa to Europe
where cafes would become famous
and people would eventually sit with their cappuccinos, the baristas
talking about the new war, a cup of sugar
on the table, a curled piece of lemon rind. A beret
on someone’s head, a scarf
around their neck. A bomb in a suitcase
left beneath a small table. Right now
I’m sitting near a hospital where psychotropics are being
carried down the hall in a pink cup,
where someone is lying there and he doesn’t know who
he is. I’m listening
to the couple next to me
talk about their cars. I have no idea
how I got here. The world stops at the window
while I take my little spoon and slowly swirl the cream around the lip
of the cup. Once, I had a brother
who used to sit and drink his coffee black, smoke
his cigarettes and be quiet for a moment
before his brain turned its Armadas against him, wanting to burn down
his cities and villages, before grief
became his capital with its one loyal flag and his face,
perhaps only his beautiful left eye, shimmered on the surface of his Americano
like a dark star.

by Matthew Dickman
from All-American Poem
Copper Canyon Press, 2008

Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?

Alison Abbot in Nature:

Neuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. He and his team had eliminated a key inflammation gene from a strain of mouse that usually develops symptoms of Alzheimer’s disease. The modified mice seemed perfectly healthy. They sailed through memory tests and showed barely a sign of the sticky protein plaques that are a hallmark of the disease. Yet Heneka knew that his colleagues would consider the results too good to be true.

Even he was surprised how well the mice fared; he had expected that removal of the gene, known as Nlpr3, would protect their brains a little, but not that it would come close to preventing dementia symptoms. “I thought something must have gone wrong with the experiments,” says Heneka, from the German Center for Neurodegenerative Diseases in Bonn. He reanalysed the results again and again. It was past midnight when he finally conceded that they might actually be true. Over the next couple of years, he confirmed that nothing had gone wrong with the experiments. Together with his colleagues, he replicated and elaborated on the results1. Since then, numerous studies have bolstered the link between dementia and the brain’s immune system, highlighting the cells and signals involved2. But none has managed to fully pin it down — the link seems to be slippery and dynamic, changing as the disease progresses.

More here.

Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?

Alison Abbot in Nature:

BrainNeuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. He and his team had eliminated a key inflammation gene from a strain of mouse that usually develops symptoms of Alzheimer’s disease. The modified mice seemed perfectly healthy. They sailed through memory tests and showed barely a sign of the sticky protein plaques that are a hallmark of the disease. Yet Heneka knew that his colleagues would consider the results too good to be true.

Even he was surprised how well the mice fared; he had expected that removal of the gene, known as Nlpr3, would protect their brains a little, but not that it would come close to preventing dementia symptoms. “I thought something must have gone wrong with the experiments,” says Heneka, from the German Center for Neurodegenerative Diseases in Bonn. He reanalysed the results again and again. It was past midnight when he finally conceded that they might actually be true. Over the next couple of years, he confirmed that nothing had gone wrong with the experiments. Together with his colleagues, he replicated and elaborated on the results1. Since then, numerous studies have bolstered the link between dementia and the brain’s immune system, highlighting the cells and signals involved2. But none has managed to fully pin it down — the link seems to be slippery and dynamic, changing as the disease progresses.

More here.