Emily Cataneo in Undark:
When the Godwin sisters would visit their grandmother Jeanne in Carson City, Nevada when they were growing up in the 1970s, Jeanne would pull out the dreaded juicer. She’d pulverize a mixture of carrot, celery, and spinach juice for the girls, then coax them to drink it. The sisters hated the concoction, but choked it down anyway, because they didn’t want to upset their grandmother: Jeanne had lost her husband and two of her three daughters to cancer, and she hoped that this healthy mixture would save her granddaughters from the rest of her family’s fate.
Jeanne didn’t know it at the time, but diet hadn’t caused her husband’s and children’s deaths. Her family were the unlucky carriers of a mutation on the p53 gene. When it’s working, p53 acts as a tumor suppressor, stamping out malignancies before they can grow and spread. This gene is so important that one scientist called it the “guardian of the genome.” People with the mutation, which causes an extremely rare disorder called Li-Fraumeni Syndrome, have a defective p53 gene, which means no brakes on tumors flourishing in their bodies. Families with this syndrome often lose a cascade of loved ones to breast cancer, lung cancer, pancreatic cancer, and more.
More here.
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