Sean Carroll’s Mindscape Podcast: Lynne Kelly on Memory Palaces, Ancient and Modern

Sean Carroll in Preposterous Universe:

Memory takes different forms. Memories can be encoded in the strength of neural connections in our brains, but there’s a sense in which photographs and written records are memories as well. What did people do before such forms of memory even existed? Lynne Kelly is a science writer and researcher who specializes in forms of memory in the ancient world, as well as a competitive memory expert in her own right. She has theorized that ancient structures such as Stonehenge might have served as memory palaces, encoding social knowledge over extended periods of time. We talk about how to improve your own memory, the origin of religion, and how prehistoric cultures preserved their know-how.

More here.

Democracy is the planet’s biggest enemy

David Runciman in Foreign Policy:

The climate crisis is an issue that requires long-term thinking across the generations, yet electoral politics is geared toward responding to immediate grievances. Politicians can talk about taking the long view, but without institutional changes to the way we practice democracy, they are unlikely to look beyond short-term political gains.

The young and the old increasingly look like two distinct political tribes, and the differences are perhaps starkest over climate change. Recent polling in Britain indicates that for nearly half of all voters aged 18 to 24, global warming represents the most pressing issue of our time. Less than 20 percent of voters over 65 think the same. In the United States, only 10 percent of eligible voters aged 18 to 29 describe climate change as a “not very serious problem,” compared with 40 percent of those over 65 who call it that.

Observing the generational divide on climate change is easier than accounting for it.

More here.

Auden’s September 1, 1939

Jay Parini at Literary Review:

Few political poems strike emotional pay dirt with such consistency and effect as ‘September 1, 1939’. In the sprung rhythm of his three-beat line, with each of his eleven-line stanzas containing one sentence, the language leaps at our hearts and minds. Auden’s infamous cleverness and his wide allusiveness continue after many readings to startle in satisfying ways, even when we don’t recall exactly ‘what occurred at Linz’ or really know ‘What huge imago made/A psychopathic god’. What follows, of course, from these puzzling lines is the poem’s most clarifying moment: ‘I and the public know/What all schoolchildren learn,/Those to whom evil is done/Do evil in return.’

I had the good fortune to meet Auden at Oxford in 1972, a year before his death, when he had effectively come home to Christ Church to die. He was, at this time, a kindly and yet deeply witty and acerbic man who seemed to be in search of his dotage and failing badly to discover it.

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How Ed Sanders, A Peace-Loving Poet, Wrote the Definitive Account of The Manson Murders

Sarah Weinman at Poetry Magazine:

Around October 20, 1969, Sanders received a copy of an ecology newsletter called Earth Read-Out in the mail. The newsletter reprinted a five-day-old San Francisco Chronicle story describing two police raids on a remote desert ranch in California: “A band of nude and long-haired thieves who ranged over Death Valley in stolen dune buggies” had been rounded up. Sanders read the story with some interest, then put it aside. Six weeks later, when Manson’s picture was plastered across the front pages of newspapers, along with reports of the horrific crimes he’d allegedly orchestrated, Sanders recalled the thieves in the desert.

Sanders, 30 years old at the time, had lived a life and pursued a career only a few degrees of separation from Manson’s. The native Missourian had dropped out of college and moved to New York City in 1958 to study Greek at NYU, where he found kindred spirits among the Beats and the folksingers in the coffeehouses of Greenwich Village. He’d been arrested for protesting the proliferation of nuclear submarines and found early fame with Poem from Jail (1963), published by City Lights Books.

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Fra Angelico’s Divine Emotion

Cody Delistraty at The Paris Review:

In the summer of 1873, Henry James visited a former monastery on Piazza San Marco in Florence. Surrounded by a scattering of low-slung, washed-out government buildings and conical Tuscan cypresses, the church and convent were in what is still the city’s center. When James first entered the convent, he saw Fra Angelico’s The Crucifixion with Saints in the chapter room. A brightly colored, semicircle fresco about thirty feet wide, Crucifixion depicts Christ and the two thieves on either side of him, nailed to their crosses, as saints and witnesses grieve below. “I looked long,” James wrote. “One can hardly do otherwise.” As the author moved throughout what had then just become a museum, he felt a spiritual urge, even though he had rejected his Christian upbringing. “You may be as little of a formal Christian as Fra Angelico was much of one,” he wrote in Italian Hours. “You yet feel admonished by spiritual decency to let so yearning a view of the Christian story work its utmost will on you.” Even Angelico’s colors, he added, seem divinely infinite, “dissolved in tears that drop and drop, however softly, through all time.”

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The “unwarranted hype” of stem cell therapies

Jules Montague in BBC:

Jay Shetty is 8 years old. He is smart and bright, says his mother Shilpa, even if he can’t do all the things his younger brother can. “Jay doesn’t sit up or use his hands much. He’s non-verbal and we don’t know how well he can see,” she says. “But he plays with us and tries to copy everything his younger brother Kairav does.”

Jay has cerebral palsy. In his early years, Shilpa was desperate to find anything that might help him. Scouring the internet late each night, she read about a stem cell trial at Duke University in North Carolina but Jay wasn’t eligible. When Kairav was born in 2015, Shilpa and her husband stored their younger son’s umbilical cord blood, which was rich in blood stem cells, hoping another trial would emerge. It did, and this time, children with sibling cord blood could participate. Was she worried about the risks for Jay? “It wasn’t invasive and it couldn’t do any harm really.” To raise the £15,000 ($18,200) treatment bill, they supplemented money they had already fundraised for private physiotherapy and hydrotherapy with a personal loan and a further fundraising push supported by the cord bank where Kairav’s cord blood had been stored. Cerebral palsy is a group of lifelong conditions that affect movement and coordination. In Jay’s case, Shilpa explains, there were complications around the time of his birth that led to the condition. There is no cure for cerebral palsy but physiotherapy, speech therapy and occupational therapy can help some symptoms. Shilpa hoped, though, that Jay’s stem cell therapy – a two-hour infusion into his veins – would bring benefits far beyond everything they had tried before.

We all have stem cells – these are building-block cells of sorts, with the ability to develop into a wide range of specialised cell types, such as muscle, skin, or brain cells. Stem cells not only replenish our old cells but also spring into action to repair and replace injured tissue. As a result, they have been likened to our own army of microscopic doctors, but that army is relatively small. The excitement around stem cell therapy revolves around the ability to grow more of these cells in the laboratory so they can be used to produce new tissue, replace damaged cells, and unravel disease mechanisms.

More here.

Metabolic Biomarker “Score” May Predict Death in Next 5–10 Years

Emma Yasinsky in The Scientist:

One day, doctors may be able to use the metabolites in blood samples to predict the likelihood of a person surviving another five to 10 years, according to a newly developed tool described today (August 20) in Nature Communications. The authors of the report say the information may be useful in helping decide whether or not to do surgery on patients who are frail or could serve as endpoints in new clinical trials. The study “shows the potential usefulness of metabolomic biomarkers,” says Paola Sebastiani, a biostatistician at Boston University who was not involved in the study. She adds that the field will need longitudinal studies in the future to assess the biomarkers’ clinical usefulness. The team’s goal was to find blood-based biomarkers that can “indicate risk of vulnerability, especially if that information provides opportunities for an improvement in lifestyle or better treatment,” says Eline Slagboom, a molecular epidemiologist at Leiden University and the senior author on the study.

Doctors often use functionality measures such as grip strength and gait to determine an elderly patient’s health status, but these measures are imprecise. Other traditional biomarkers don’t necessarily apply to patients who hit a certain age. “For example, a somewhat higher weight, blood pressure, or cholesterol level is not as bad for individuals over 80 years of age as compared to younger individuals,” says Slagboom. So her group undertook the largest study of its kind to detect blood-based biomarkers of metabolism. “We have worked with biobanks from all over the world for three years to come to these results.” The team used data from 12 cohorts of individuals of European descent, a total of 44,168 people aged 18–109, to identify 14 metabolites that they could use to develop a “score” to evaluate a person’s risk for mortality at five and 10 years out. During the study’s follow up, which ranged from around three years to nearly 17, depending on the cohort, 5,512 of the participants died.

More here.

Wednesday Poem

The Origin of Light

For a thousand years, the nature of light
was a source of debate, a question
that split the learned, who wondered if sight
originated as a beam coming in
from outside-the sun-or as a substance
generated inside, a stuff we shoot
out, to bathe the world and its occupants?
Curious. I never knew of this dispute
until a patient, about week before he died
of cancer, told me the story of Ali
al-Hasan, the curious man who tried
staring into the sun for as long as he
could take it. When the pain became too sharp
to stand, he understood, but it was dark.

by Jack Coulehan
from Rattle #16, Winter 2001

The Sound of Philosophy

Dmitri Tymoczko in the Boston Review:

Milton Babbitt and John Cage, two of the most notorious postwar American composers, are often thought to be antipodal figures. Babbitt is straight, Jewish, politically conservative, and southern, a skeptical rationalist who talks like a mathematician on speed. Cage–who died in 1992–was gay, goyish, politically left, and Californian, a genial fruitcake whose enthusiasms ran toward astrology, mushrooms, Zen, and anarchist politics. Babbitt’s music is fastidiously organized, each of his notes carefully placed within multiple nested rhythmic and melodic patterns. Cage’s music, by contrast, is scrupulously disorganized, composed randomly–for instance by tossing coins or tracing astronomical maps onto music paper. Not surprisingly, Babbitt is an academic, and has many students who teach at music departments throughout the country. Cage, who never graduated from college, was an auto-didact (more or less), and has had at least as much influence on visual arts and popular music as on the world of academic musical composition.

Yet behind these differences there lurks a fascinating, and more fundamental similarity. Leave aside the fact that even expert listeners sometimes have difficulty distinguishing Babbitt’s sophisticated musical puzzles from Cage’s mystical soundscapes. The important point is that Babbitt and Cage straddle the line between philosophy and art.

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Can New Species Evolve From Cancers?

Christie Wilcox in Quanta:

Aggressive cancers can spread so fiercely that they seem less like tissues gone wrong and more like invasive parasites looking to consume and then break free of their host. If a wild theory recently floated in Biology Direct is correct, something like that might indeed happen on rare occasions: Cancers that learn how to roam between hosts may gradually evolve into their own multicellular species. Researchers are now scrutinizing a peculiar group of marine parasites called myxosporeans to see whether they might be the first known example.

Even among microscopic parasites, myxosporeans are enigmatic. They were first discovered nearly two centuries ago, and more than 2,000 species are recognized today. Their complex life cycles make study particularly difficult: It wasn’t until the 1980s that scientists realized the ones found in fish were the same species as those found in worms, and not completely different classes of parasite. And while most parasites are content merely to snuggle into their animal host’s tissues, myxosporeans often take up residence inside a host’s own cells.

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Meritocracy Harms Everyone

Daniel Markovits in The Atlantic:

In the summer of 1987, I graduated from a public high school in Austin, Texas, and headed northeast to attend Yale. I then spent nearly 15 years studying at various universities—the London School of Economics, the University of Oxford, Harvard, and finally Yale Law School—picking up a string of degrees along the way. Today, I teach at Yale Law, where my students unnervingly resemble my younger self: They are, overwhelmingly, products of professional parents and high-class universities. I pass on to them the advantages that my own teachers bestowed on me. They, and I, owe our prosperity and our caste to meritocracy.

Two decades ago, when I started writing about economic inequality, meritocracy seemed more likely a cure than a cause. Meritocracy’s early advocates championed social mobility. In the 1960s, for instance, Yale President Kingman Brewster brought meritocratic admissions to the universitywith the express aim of breaking a hereditary elite. Alumni had long believed that their sons had a birthright to follow them to Yale; now prospective students would gain admission based on achievement rather than breeding. Meritocracy—for a time—replaced complacent insiders with talented and hardworking outsiders.

Today’s meritocrats still claim to get ahead through talent and effort, using means open to anyone. In practice, however, meritocracy now excludes everyone outside of a narrow elite.

More here.

Why Does the U.S. Army Own So Many Fossils?

Sabrina Imbler at Atlas Obscura:

Rather unintentionally, the U.S. Army Corps of Engineers owns an enormous collection of fossils that would turn any paleontologist green with envy. “The U.S. Army Corps has collections that span the paleontological record,” says Nancy Brighton, a supervisory archaeologist for the Corps. “Basically anything related to animals and the natural world before humans came onto the scene.” The Corps never set out to amass this prehistoric tome. Rather, the fossils—from trilobites to dinosaurs, and everything in between—came as a kind of byproduct of the Corps’s actual, more logistical purpose: flood control (among other large-scale civil engineering projects).

The agency was created during the Revolutionary War, according to the Corps’s site. General George Washington had just ordered one of his colonels to build fortifications at Bunker Hill when the Continental Congress realized the task was impossible, as they did not actually employ any engineers trained in military fortifications.

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The Enduring Relevance of George Orwell’s 1984

Jeffrey Wasserstrom at The New Statesman:

Lynskey’s background in musical criticism also leads to a highly original intervention in the ongoing debate over how authors influence one another. This has long been a contentious subject with respect to Orwell. Before composing 1984, Orwell claimed that Aldous Huxley’s classic satire warning of the dangers of hedonism and materialism, Brave New World (1932), essentially plagiarised Yevgeny Zamyatin’s We, a Soviet science fiction novel published in the 1920s. Critics later raised their eyebrows at how much Orwell’s own account of a conformist-mad land, which was published in 1949, owed to both of those earlier works.

Instead of trying to establish clear lineages and settle disputes over originality, Lynskey – who devotes a stimulating chapter to Zamyatin – approaches these dystopian visions the way that some musicologists handle folk songs: as entities that are modified so promiscuously when taken up by different figures that they become collectively created.

more here.

Tuesday Post

You Are Who I Love

You, selling roses out of a silver grocery cart

You, in the park, feeding the pigeons
You cheering for the bees

You with cats in your voice in the morning, feeding cats

You protecting the river   You are who I love
delivering babies, nursing the sick

You with henna on your feet and a gold star in your nose

You taking your medicine, reading the magazines

You looking into the faces of young people as they pass, smiling and saying, Alright!
which, they know it, means I see you, Family. I love you. Keep on.

You dancing in the kitchen, on the sidewalk, in the subway waiting for the train
because Stevie Wonder, Héctor Lavoe, La Lupe

You stirring the pot of beans, you, washing your father’s feet

You are who I love, you
reciting Darwish, then June

Feeding your heart, teaching your parents how to do The Dougie, counting to 10,
reading your patients’ charts

You are who I love, changing policies, standing in line for water, stocking the food
pantries, making a meal

You are who I love, writing letters, calling the senators, you who, with the seconds of
your body (with your time here), arrive on buses, on trains, in cars, by foot to stand in
the January streets against the cool and brutal offices, saying: YOUR CRUELTY
DOES NOT SPEAK FOR ME

Read more »

Realism, an Idea Whose Time Has Come…Again

Paul Nedelisky at The Hedgehog Review:

Realism is back. After several decades of denying there was anything beyond interpretation, thinkers in the postmodern tradition are returning to reality. A new cluster of Continental thinkers—including Maurizio Ferraris, Graham Harman, and Markus Gabriel—argue that realism was unjustly, and unwisely, abandoned. While part of their motivation is purely philosophical, they also see realism as a defense against a crude, Nietzschean style of politics exemplified by a crop of world leaders who act as though the truth is whatever they say it is. Even in sociology, the thin, metaphysics-free theorizing of rational actor theory has been joined by “critical realism,” a metaphysically heavyweight view that accepts that things have objective natures that make them what they are, and powers that enable real causal interactions between things.

Analytic philosophy, meanwhile, has remained predominantly realist since its inception, but it has also struggled with whether we can really be justified in claiming knowledge of a world outside our heads, or any knowledge at all. Lately, however, thinkers from its fringes have challenged this recurring skepticism, pointing to allegedly flawed but deep-seated assumptions in this Cartesian legacy—e.g., that our ideas of the world are radically separate from the external world itself—and reminding analytic philosophy’s adherents that we are thinkers embodied in the real world, even prior to conscious thought.

more here.

Going Home – rich, sad reflections from Ramallah

Alex Preston in The Guardian:

Ramallah, in the heart of the West Bank, is only a few miles north of Jerusalem, its nose pressed up against the dashes of Palestine’s borders on the maps, official markers of the city’s – and the country’s – provisional nature. It is a place of scarcely 30,000 inhabitants, historically a Christian city (although now the majority are Muslim) and also one of cold winters and carefully tended gardens, chosen by the PLO as its de facto headquarters following the Oslo accords of 1993 and 1995. It is, above all, a city of authors, home to Palestine’s greatest poet, the late Mahmoud Darwish, and the man we can now recognise as its greatest prose writer, Raja Shehadeh.

Shehadeh won the Orwell prize for his 2007 book Palestinian Walks and published a powerful memoir of a cross-border friendship, Where the Line Is Drawn, in 2017. These books built on earlier memoirs, Strangers in the Houseand When the Bulbul Stopped Singing, written at the beginning of the century, during the second intifada, when any optimism that the Oslo agreements might bring peace had died, and a new kind of hope gripped Palestine – that desperate and violent resistance might succeed where political negotiation had failed.

Palestinian Walks was the story of 27 years’ worth of walking in the hills of the West Bank, while Going Hometakes place on a single day, 5 June 2017, the 50th anniversary of the Israeli invasion of Palestine. Shehadeh sets out to walk to a meeting at his office – he’s a practicing lawyer as well as the founder of Al-Haq, the human rights campaign group – and strolls through the city in which he has spent most of his life. Normally, the walk to his office takes only 45 minutes, but he stretches it out to four hours, chewing over the history of his city. After the meeting, he walks home, reflecting on “how the city I grew up in has remained with me”. Going Home is a travelogue, a lament, a record of a vanishing city and its near-vanished inhabitants, most of whom (despite World Bank incentives) have fled to the US or Europe.

More here.

Scientists Discover New Cure for the Deadliest Strain of Tuberculosis

Donald McNeil Jr. in The New York Times:

TSAKANE, South Africa — When she joined a trial of new tuberculosis drugs, the dying young woman weighed just 57 pounds. Stricken with a deadly strain of the disease, she was mortally terrified. Local nurses told her the Johannesburg hospital to which she must be transferred was very far away — and infested with vervet monkeys. “I cried the whole way in the ambulance,” Tsholofelo Msimango recalled recently. “They said I would live with monkeys and the sisters there were not nice and the food was bad and there was no way I would come back. They told my parents to fix the insurance because I would die.” Five years later, Ms. Msimango, 25, is now tuberculosis-free. She is healthy at 103 pounds, and has a young son. The trial she joined was small — it enrolled only 109 patients — but experts are calling the preliminary results groundbreaking. The drug regimen tested on Ms. Msimango has shown a 90 percent success rate against a deadly plague, extensively drug-resistant tuberculosis.

…But in the trial Ms. Msimango joined, nicknamed Nix-TB, patients took only five pills a day for six months. The pills contain just three drugs: pretomanid, bedaquiline and linezolid. (Someday, the whole regimen might come in just one pill, as H.I.V. drugs do, one expert said.) Until recently, some advocacy groups opposed pretomanid’s approval, saying the drug needed further testing. But other TB experts argued that the situation is so desperate that risks had to be taken. Dr. Gerald Friedland, one of the discoverers of XDR-TB and now an emeritus professor at Yale’s medical school, called Nix “a wonderful trial” that could revolutionize treatment: “If this works as well as it seems to, we need to do this now.”

More here.

Guns and More Guns

by Michael Liss

I don’t know a lot about guns.

I live in New York, which has comparatively restrictive gun laws, I don’t own any, I don’t hunt (and didn’t grow up hunting), and I wasn’t in the service. I don’t have the emotional bonds that others who grew up around them might. The entire sum of my personal experience was several years of summer-camp riflery practice: .22 caliber single-action rifles that might have been previously used in the Boer War. We marched them over to a “range” consisting of a shack with mattresses on the floor, a lot of tree-stumps, and a contraption with pulleys and clotheslines to move the targets, and competed for NRA sharpshooter patches.

That is just about my last firsthand memory of guns, so, to reiterate, I just don’t know very much about them. I also can’t tell you about makes, models, types; whether a particular firearm is an “assault weapon”; or which one (or six) John Wick would pick. As I can’t speak knowledgeably about guns themselves, I’m going to stay in my lane as a lawyer who writes about history and politics, and talk about guns and gun control in that context. In doing so, I expect to irritate virtually everyone who reads this.

First, the Second Amendment exists. It doesn’t matter whether you or I agree with it—it’s there. We can argue about what the Framers intent was when they wrote it, or the intent of the voters of the States that ratified it, but you can’t wish it away. This is not an endorsement of unlimited guns in every hand and every place, and it is certainly not a moral judgment. It is just a reflection of reality. When government acts restrictively on guns, it takes something from gun owners, and the entire legal analysis from that point forward hinges on whether it is taking too much. Read more »