How many scientific papers just aren’t true?

Donna Laframboise in Spectator:

LabWe’re continually assured that government policies are grounded in evidence, whether it’s an anti-bullying programme in Finland, an alcohol awareness initiative in Texas or climate change responses around the globe. Science itself, we’re told, is guiding our footsteps. There’s just one problem: science is in deep trouble. Last year, Richard Horton, editor of the Lancet, referred to fears that ‘much of the scientific literature, perhaps half, may simply be untrue’ and that ‘science has taken a turn toward darkness.’ It’s a worrying thought. Government policies can’t be considered evidence-based if the evidence on which they depend hasn’t been independently verified, yet the vast majority of academic research is never put to this test. Instead, something called peer review takes place. When a research paper is submitted, journals invite a couple of people to evaluate it. Known as referees, these individuals recommend that the paper be published, modified, or rejected.

If it’s true that one gets what one pays for, let me point out that referees typically work for no payment. They lack both the time and the resources to perform anything other than a cursory overview. Nothing like an audit occurs. No one examines the raw data for accuracy or the computer code for errors. Peer review doesn’t guarantee that proper statistical analyses were employed, or that lab equipment was used properly. The peer review process itself is full of serious flaws, yet is treated as if it’s the handmaiden of objective truth. And it shows. Referees at the most prestigious of journals have given the green light to research that was later found to be wholly fraudulent. Conversely, they’ve scoffed at work that went on to win Nobel prizes.

More here.