Breakthrough allows scientists to watch how molecules morph into memories

From MedicalXpress:

BrainIn the research described in the two Science papers, the Einstein researchers stimulated neurons from the mouse's hippocampus, where memories are made and stored, and then watched fluorescently glowing beta-actin mRNA molecules form in the nuclei of neurons and travel within dendrites, the neuron's branched projections. They discovered that mRNA in neurons is regulated through a novel process described as “masking” and “unmasking,” which allows beta-actin protein to be synthesized at specific times and places and in specific amounts. Neurons come together at synapses, where slender dendritic “spines” of neurons grasp each other, much as the fingers of one hand bind those of the other. Evidence indicates that repeated neural stimulation increases the strength of synaptic connections by changing the shape of these interlocking dendrite “fingers.” Beta-actin protein appears to strengthen these synaptic connections by altering the shape of dendritic spines. Memories are thought to be encoded when stable, long-lasting synaptic connections form between neurons in contact with each other.

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