Mariana Lenharo in Nature:
The latest generation of obesity drugs might have another potential benefit: improving fertility in men. A systematic review presented today at the Endocrine Society’s annual meeting in Chicago, Illinois, suggests that GLP-1 medications might increase testosterone levels and help to improve the quality of sperm in men with obesity.
The evidence is still preliminary, and more robust trials are needed to confirm the association, says review co-author Pratibha Natesh, an endocrinologist at Warwick Medical School in Coventry, UK. But emerging evidence from other sources points in the same direction. Most of the next-generation obesity drugs that have come on the market in the past five years work by binding to the same receptor as a natural hormone called glucagon-like peptide 1 (GLP-1), creating a feeling of fullness. To learn how the drugs affect male fertility, Natesh and her colleagues searched the literature for randomized controlled trials of GLP-1 drugs that included measurements of testosterone levels in men. They found only five studies.
More here.
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