From Medical News Today:
Unlike previously proposed life-extending drugs and treatments, which often have poor side-effect profiles, work in only one sex, or extend life without improving health, IL-11 does not seem to have these limitations. Although these findings are currently limited to mice, they suggest the intriguing possibility that similar effects could be seen in elderly humans.
For example, treated mice exhibited fewer cancers and avoided typical signs of aging and frailty, showing reduced muscle wasting and improved muscle strength. Essentially, the older mice receiving anti-IL-11 were healthier. Anti-IL-11 treatments are already undergoing human clinical trials for other conditions, offering exciting opportunities to study its effects on aging in the future. The researchers have been studying IL-11 for many years and, in 2018, were the first to demonstrate that IL-11 is a pro-fibrotic and pro-inflammatory proteinTrusted Source, challenging the long-held belief that it was anti-fibrotic and anti-inflammatory.
More here.
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