From Medical Xpress:

Immunotherapy is a promising strategy to treat cancer by stimulating the body’s own immune system to destroy tumor cells, but it only works for a handful of cancers. MIT researchers have now discovered a new way to jump-start the immune system to attack tumors, which they hope could allow immunotherapy to be used against more types of cancer.

Their novel approach involves removing tumor cells from the body, treating them with chemotherapy drugs, and then placing them back in the tumor. When delivered along with drugs that activate T cells, these injured cancer cells appear to act as a distress signal that spurs the T cells into action.

“When you create cells that have DNA damage but are not killed, under certain conditions those live, injured cells can send a signal that awakens the immune system,” says Michael Yaffe, who is a David H. Koch Professor of Science, the director of the MIT Center for Precision Cancer Medicine, and a member of MIT’s Koch Institute for Integrative Cancer Research.

In mouse studies, the researchers found that this treatment could completely eliminate tumors in nearly half of the mice.

More here.

Sven Birkerts in the Los Angeles Review of Books:

Teaching writing, unlike most other kinds of teaching, is an intervention, closer to therapy than to any transmissible instruction. But with all the fussing about craft — anyone who teaches has a personal punch-list — we almost never hear about or get close to the real business, the meld. Maybe because each teacher is different and each interaction draws on a unique set of human variables.

Let me start at the beginning. Bennington MFA: the residency

Day one. The residency begins: greetings all around, the hors d’oeuvres and the better wine laid out in the big cafeteria space. Reminders have been posted and emailed that the first workshop starts tomorrow at one o’clock in the Barn. But really, the whole business has begun already. Because, of course, the student-teacher assignments have been made, and the first workshop packets have been sent to everyone, and it’s a good bet that everyone has read everything in order to suss out the field. Most students have surely Googled their instructor.

More here.

Alexander Hellemans in Quanta:

In an increasingly data-driven world, mathematical tools known as wavelets have become an indispensable way to analyze and understand information. Many researchers receive their data in the form of continuous signals, meaning an unbroken stream of information evolving over time, such as a geophysicist listening to sound waves bouncing off of rock layers underground, or a data scientist studying the electrical data streams obtained by scanning images. These data can take on many different shapes and patterns, making it hard to analyze them as a whole or to take them apart and study their pieces — but wavelets can help.

Wavelets are representations of short wavelike oscillations with different frequency ranges and shapes. Because they can take on many forms — nearly any frequency, wavelength and specific shape is possible — researchers can use them to identify and match specific wave patterns in almost any continuous signal. Because of their wide versatility, wavelets have revolutionized the study of complex wave phenomena in image processing, communication and scientific data streams.

More here.

Tom Bartlett in the Chronicle of Higher Education:

Sheng, a professor of composition at the University of Michigan’s School of Music, Theater, and Dance, said he was sorry for showing a 1965 film version of Othello, starring Laurence Olivier in blackface, during an undergraduate class last month. In the first apology, sent to students shortly after the class ended, he called the film’s use of blackface “racially insensitive and outdated” and wrote that it was “wrong for me” to show it. He promised they would discuss the issue in the next class. As it turns out, he wouldn’t get that chance.

In an email sent several days later, Sheng again apologized, this time at more length, writing that he did not initially realize the “graveness of my action” and that he “failed to recognize that showing a heavy makeup of a black face in fact has a strong racist content.” But that didn’t stop calls for Sheng, a renowned composer and pianist who was selected as MacArthur fellow in 2001, to be removed from the class.

More here.

June

You stand in the scuffed Box Brownie square,
pretty and slim in your summer shorts,
your Heddy Lemarr hair, in front of a stage-left
parasol somewhere on the Côte d’Azure
between your two young daughters,
like the border guard between rival nations.
All of us squinting in the unfamiliar sun.

The past, they say, is another country,
one I barely remember as I search
our eyes to understand the real story.
I forget what was going on in front of us.
A man waving to his wife from the sea,
perhaps, a barefoot boy in a sombrero
selling sugared almonds on the beach,
children in a pedallo, laughing.

Years later, as you lay
trying to catch your shallow breath
in the summer heat –
the same month as your name,
the same month as your birth –
I sat beside your cot holding
your frail hand in mine
like a child in danger of getting lost –
wanting to tell you,
this is who I am, this has been the story.
That there are no drafts, no proofs
to be corrected, that we do not
get to write it again.

by Sue Hubbard
from: the punch magazine

Jackson Arn at Art in America:

Yet the fact remains that Harold Rosenberg is to the intellectuals of midcentury Manhattan what Andrew McCarthy is to the Brat Pack of 1980s Hollywood—the most minor of the major, the one people may have heard of but couldn’t tell you much about. He wrote for Partisan Review, Commentary, and the other august little magazines that flourished between the rise of the New Deal and the fraying of the New Left. At the time of his death, he’d been the New Yorker’s art critic for twelve years. He knew everyone, sat on all the panels, went to all the parties; he even had an archnemesis in the art critic Clement Greenberg. He proposed daring theories and coined arresting phrases, most of which have been banished to the dustier corners of the library. Still, one good biography is all it would take to get a comeback going.

Instead, he got Harold Rosenberg: A Critic’s Life. Debra Bricker Balken has dug the man up, only to bury him in sentences like “Rosenberg’s sense of ostracism affected him emotionally.”

more here.

Hal Foster at Artforum:

The wager made by Atkins is that if reality can be derealized by such technologies, it might also be rediscovered there, and this might occur in a few ways. First, he believes that, once outmoded, technology passes over to the side of “base materiality”; its very clunkiness becomes a reality effect. Atkins adapts the term corpsing—the moment when an actor breaks character and so dispels the illusion of the performance—“to describe a kind of structural revelation more generally”; his examples are when a vinyl record jumps or a streaming movie buffers. To corpse a medium is to expose its materiality, even to underscore its mortality, and in this moment the real might poke through. Second, punctuated by the gestural tics of the Atkins avatar, The Worm is also rife with manufactured glitches—sudden blurs, flares, beeps, and crackles—and these apparent cracks in the artifice might provide another opening to the real. Although these reality effects are artificial, “they baffle the signs of reality by parodying them, engendering a new kind of realism.”⁷ Third, if the real might be felt when an illusion fails, so too might it be sensed when that illusion is “glazed with effects to italicize the artifice,” that is, when illusionism is pushed to a hyperreal point.

more here.

Elizabeth Svoboda in Nature:

In a laboratory in Israel, an incubator drum spins on a bench. The two glass bottles attached to the drum contain mouse embryos, each the size of a grain of rice, with translucent, pulsing hearts.

Whole mouse embryos have typically been grown in vitro for only about 24 hours. But by carefully tuning the mix of chemicals that the mouse embryos are bathed in, a team at the Weizmann Institute of Science in Rehovot, Israel, managed to sustain five-day-old embryos outside the uterus for six more days¹. This is about one-third of their normal three-week gestation and parallels some events in the first trimester of human embryonic development. Growing human embryos using similar techniques could allow scientists to study processes integral to human development that have long been hidden from view. “This may become the gold standard of looking at human embryonic biology,” says Jacob Hanna, a stem-cell biologist and lead researcher on the project at the Weizmann Institute of Science.

This and other recent breakthroughs, such as the creation of human-embryo-like structures from pluripotent stem cells, give scientists an arsenal of tools with which to probe further into early human development. Hanna’s drum incubator and these human-embryo models promise to allow more detailed study of processes such as gastrulation — in which three germ-cell layers develop into an array of tissues — and organ formation. Hanna and others say that understanding these crucial embryonic phases is essential to devising therapies that correct developmental errors, as well as to creating transplantable human organs.

More here.

Dear Obeidallah in Salon:

It can happen here. The “it” ought to be obvious by now: an authoritarian or even fascist regime in the United States. That was a big reason why Harvard professor Steven Levitsky, along with his colleague Daniel Ziblatt, published the 2018 book “How Democracies Die.” They wanted to warn Americans of the dangerous signs they saw in Donald Trump’s presidency that followed the authoritarian playbook.

So where are we now in terms of our democracy? I spoke with Levitsky recently for Salon Talks, and here’s one line that really stood out: Levitsky told me, “Five years ago I would have laughed you out of the room if you suggested our democracy could die.” But today, he added, we see the Republican Party apparently focused on breaking our democracy. In a nutshell, Levitsky believes the threat to our democracy is more acute today than when Trump was in the White House, since the GOP is desperate to retain its fading power in the face of hostile demographic change.

Levitsky describes today’s GOP as “clearly an authoritarian party.” Worse yet, it’s no longer all about Trump. He sees the GOP continuing on its anti-democratic path for years to come, saying that even the contested term “fascist” is becoming more defensible given the GOP’s defense or denial of the Jan. 6 Capitol attack.

More here.

Walter Veit in the Australasian Philosophical Review:

Genevieve Lloyd has done much to promote serious engagement with Baruch Spinoza and has demonstrated many ways in which Spinoza can inform and challenge current debates in the philosophical mainstream. In her article in this issue, Lloyd invites us to challenge the simplistic caricature of Spinoza as a paradigm ‘rationalist’, thus providing us with rich insights into the subtleties of Spinoza’s naturalist view on minds, knowledge, and reason. This more accurate picture, however, offers a striking similarity to the work of Daniel Dennett. Indeed, Spinoza and Dennett are alike in sharing their fervent opposition to Descartes’ conception of mind and body.

Lloyd [2021] herself alludes to Dennett when she suggests that a serious engagement with Spinoza might allow us to provide an alternative framing of the problem of consciousness—one that replaces the current metaphors with what Dennett [1991: 455] would describe as novel ‘tools of thought’. While Lloyd [2017] has addressed the connection between Spinoza and the problem of consciousness in a previous publication, little has been made of the connection between these two Anti-Cartesian conceptions of the mind.

More here.

Colleen Walsh in The Harvard Gazette:

Testimony by former Facebook employee Frances Haugen, who holds a degree from Harvard Business School, and a series in the Wall Street Journal have left many, including Joshua Greene, Harvard professor of psychology, calling for stricter regulation of the social media company. Greene, who studies moral judgment and decision-making and is the author of “Moral Tribes: Emotion, Reason, and the Gap Between Us and Them,” says Facebook executives’ moral emotions are not well-tuned to the consequences of their decisions, a common human frailty that can lead to serious social harms. Among other things, the company has been accused of stoking division through the use of algorithms that promote polarizing content and ignoring the toxic effect its Instagram app has on teenage girls. In an interview with the Gazette, Greene discussed how his work on moral dilemmas can be applied to Facebook. The interview has been edited for length and clarity.

More here.

J. Bradford DeLong in Project Syndicate:

If you are concerned about the well-being of the United States and interested in what the country could do to help itself, stop what you are doing and read historian Geoffrey Kabaservice’s superb 2012 book, Rule and Ruin: The Downfall of Moderation and the Destruction of the Republican Party, from Eisenhower to the Tea Party. To understand why, allow me a brief historical interlude.

Until roughly the start of the seventeenth century, people generally had to look back in time to find evidence of human greatness. Humanity had reached its peak in long lost golden ages of demigods, great thinkers, and massive construction projects. When people did look to the future for promise of a better world, it was a religious vision they conjured – a city of God, not of man. When they looked to their own society, they saw that it was mostly the same as in the past, with Henry VIII and his retinue holding court in much the same fashion as Agamemnon, or Tiberius Caesar, or Arthur.

But then, around 1600, people in Western Europe noticed that history was moving largely in one particular direction, owing to the expansion of humankind’s technological capabilities.

More here.

Benjamin Morris in The Millions:

“Live your best life.” It’s one of the most common, yet worthless, aphorisms offered today. Chipper, insipid, and surprisingly relativistic (it fits arsonists as well as anybody), this meaningless maxim is the Tic-Tac of modern aspiration, boasting all the nuance and depth of Target word-art or pastel Instagram posts. Fed up with such drivel, and equally skeptical of the therapy-industrial complex, writer Catherine Baab-Muguira urges us in her debut book of nonfiction to take the exact opposite tack: to live our worst life instead.

In Poe for Your Problems: Uncommon Advice from History’s Least Likely Self-Help Guru (Running Press), Baab-Muguira preaches the good news of one of the greatest screw-ups of all time: Edgar Allan Poe. Drawing insights on work, love, ambition, and legacy from Poe’s blazing dumpster fire of a life, she concludes that the surest way to thrive is to sabotage everything you can get your mitts on, then build something new and totally novel out of the wreckage. Her literary forebears—Richard Fariña and Charles Bukowski among others—would be proud.

Recently I posed Baab-Muguira a few questions for The Millions, which she graciously answered amid her publicity tour of Richmond pubs—knocking back local spirits in honor of her favorite local spirit.

More here.

The Second Coming

Turning and turning in the widening gyre
The falcon cannot hear the falconer;
Things fall apart; the center cannot hold;
Mere anarchy is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
The best lack all conviction, while the worst
Are full of passionate intensity.
Surely some revelation is at hand;
Surely the Second Coming is at hand.
The Second Coming! Hardly are those words out
When a vast image out of Spiritus Mundi
Troubles my sight: somewhere in sands of the desert
A shape with lion body and the head of a man,
A gaze blank and pitiless as the sun,
Is moving its slow thighs, while all about it
Reel shadows of the indignant desert birds.
The darkness drops again; but now I know
That twenty centuries of stony sleep
Were vexed to nightmare by a rocking cradle,
And what rough beast, its hour come round at last,
Slouches towards Bethlehem to be born?

by W.B. Yeats

Damian Reilly in The Spectator:

Towards what seemed like the halfway point of his show in London last night, Dave Chappelle announced to the crowd he was going to tell us something he was refusing to tell the media. He wanted us to know, he said while looking sadly at the floor, that his quarrel was not with the gay or the trans communities . No, no. Looking up and raising an index finger, he explained: ‘I’m fighting a corporate agenda that needs to be addressed.’ Thinking we still had another hour of the show to go, we cheered. ‘You fight those corporate vampires, Dave!’ we thought. He then let us know, whenever it was possible, that we should be kind to one another. Very shortly after that he raised his thumbs aloft and walked off stage: 45 minutes. Friday night tickets are £160. You show those corporate vamp… oh.