What happened when? How the brain stores memories by time

From PhysOrg:

Mem Before I left the house this morning, I let the cat out and started the dishwasher. Or was that yesterday? Very often, our memories must distinguish not just what happened and where, but when an event occurred—and what came before and after. New research from the University of California, Davis, Center for Neuroscience shows that a part of the brain called the hippocampus stores memories by their “temporal context”—what happened before, and what came after. “We need to remember not just what happened, but when,” said graduate student Liang-Tien (Frank) Hsieh, first author on the paper published March 5 in the journal Neuron. The hippocampus is thought to be involved in forming memories. But it's not clear whether the hippocampus stores representations of specific objects, or if it represents them in context. Hsieh and Charan Ranganath, professor in the Department of Psychology and the Center for Neuroscience, looked for hippocampus activity linked to particular memories. First, they showed volunteers a series of pictures of animals and objects. Then they scanned the volunteers' brains as they showed them the same series again, with questions such as, “is this alive?” or “does this generate heat?” The questions prompted the volunteers to search their memories for information. When the images were shown in the same sequence as before, the volunteers could anticipate the next image, making for a faster response. From brain scans of the hippocampus as the volunteers were answering questions, Hsieh and Ranganath could identify patterns of activity specific to each image. But when they showed the volunteers the same images in a different sequence, they got different patterns of activity.

In other words, the coding of the memory in the hippocampus was dependent on its context, not just on content. “It turns out that when you take the image out of sequence, the pattern disappears,” Ranganath said. “For the hippocampus, context is critical, not content, and it's fairly unique in how it pulls things together.” Other parts of the brain store memories of objects that are independent of their context, Ranganath noted. “For patients with memory problems this is a big deal,” Ranganath said. “It's not just something that's useful in understanding healthy memory, but allows us to understand and intervene in memory problems.”

More here.

Wednesday, March 12, 2014

Accidents will happen: An excerpt from “Command and Control”

Eric Schlosser in The Bulletin of the Atomic Scientists:

NEASHsac_3152_420pxThe Mark 36 was a second-generation hydrogen bomb. It weighed about half as much as the early thermonuclears—but 10 times more than the new, sealed-pit bombs that would soon be mass-produced for SAC [the Strategic Air Command]. It was a transitional weapon, mixing old technologies with new, featuring thermal batteries, a removable core, and a contact fuze for use against underground targets. The nose of the bomb contained piezoelectric crystals, and when the nose hit the ground, the crystals deformed, sending a signal to the X-unit, firing the detonators, and digging a very deep hole. The bomb had a yield of about 10 megatons. It was one of America’s most powerful weapons.

A B-47 bomber was taxiing down the runway at a SAC base in Sidi Slimane, Morocco, on January 31, 1958. The plane was on ground alert, practicing runway maneuvers, cocked but forbidden to take off. It carried a single Mark 36 bomb. To make the drill feel as realistic as possible, a nuclear core had been placed in the bomb’s in-flight insertion mechanism. When the B-47 reached a speed of about 20 miles an hour, one of the rear tires blew out. A fire started in the wheel well and quickly spread to the fuselage. The crew escaped without injury, but the plane split in two, completely engulfed in flames. Firefighters sprayed the burning wreckage for 10 minutes—long past the time factor of the Mark 36—then withdrew. The flames reached the bomb, and the commanding general at Sidi Slimane ordered that the base be evacuated immediately. Cars full of airmen and their families sped into the Moroccan desert, fearing a nuclear disaster.

More here.

RIP Nils Horner

And another 3QD friend also died yesterday. He too will be missed. This is Matthew Rosenberg in the New York Times:

ScreenHunter_550 Mar. 12 15.23Two men shot a Swedish reporter on a crowded street in Kabul on Tuesday, in a rare assassination-style killing of a Westerner that raised new questions about the safety of the large international presence expected to remain here after American-led combat forces depart this year.

The reporter, Nils Horner, 51, a longtime foreign correspondent for Swedish Radio, was shot two blocks from the wreckage of a restaurant where suicide attackers killed 21 people, most of them foreigners, in January. Col. Najibullah Samsour, a senior police official, said that Mr. Horner was standing outside another restaurant talking to security guards when a pair of men in what was described as traditional clothing walked up.

One of the men then drew a pistol and fired a shot into the journalist’s face, Colonel Samsour said. The men fled, and no arrests had been made by day’s end. A spokesman for the Taliban, Zabiullah Mujahid, denied that the group was involved, and no claim of responsibility was reported.

Another Afghan security official said the killer’s pistol was fitted with a silencer.

The daylight attack was the first time in years that a Westerner appeared to have been specifically targeted and killed in Kabul.

More here.

RIP Matthew Power

3QD friend Matthew Power died yesterday. He will be missed. This is Noam Cohen in the New York Times:

MattMatthew Power, a celebrated journalist whose writing took readers down the Mississippi with modern-day hobos, to the scenes of international disasters and inside the Lower East Side apartment where Allen Ginsberg spent his last days, died on Monday in Uganda. He was 39.

He was reporting on an explorer who is walking the length of the Nile when he was overcome by the heat and died, presumably of heatstroke, his wife, Jessica Benko, said.

A contributing writer at Harper’s Magazine, Mr. Power also wrote for other publications, including GQ, The New York Times and Men’s Journal, which had sent him to Uganda. His articles were in annual anthologies like “Best American Travel Writing” and “Best American Spiritual Writing,” and he was a three-time finalist for the Livingston Award for Young Journalists in international reporting.

For two Harper’s articles he visited the scene of incidents abroad that captured the attention of most Americans only briefly: the destruction of Buddha statues by the Taliban in 2000, and the collapse of a mammoth garbage dump in Quezon City, the Philippines, during heavy rains, leading to the deaths of hundreds of people living in shanties nearby.

More here. Harper's Magazine has made all his writings for them available for free here.

What do Robert Frost’s letters reveal?

Robert-frost-processedAdam Plunkett at Poetry Magazine:

It’s hard to shake the feeling, after reading the first volume of Robert Frost’s letters, recently published by Harvard University Press, of having come to know him somehow less than you would have after reading just the poems from those years. How could this be? Factually invaluable, the letters show much of Frost’s tortuous road from ambition to accomplishment, from newspaperman, factory worker, two-time Ivy League dropout, and middling poultryman to transatlantically acclaimed nature poet. But the more you learn about his personal life, the more it can obscure his inner life. You begin to lose him as the man becomes mannered, the private man becomes a public man, and his privacy retains its intimate vulnerability almost only in his very public poems.

Take, for example, “The Road Not Taken,” a poem written during the early excitement of his fame. Frost read it at the Phi Beta Kappa induction at Tufts in 1915, in what was likely the first of countless ingenuous ceremonial botchings of the deeply vexed and mischievous poem, only to complain to his dear friend Edward Thomasthat no one had gotten the joke. The last stanza (“the sigh”) “was a mock sigh, hypocritical for the fun of the thing,” he wrote. “I doubt if I wasnt [sic] taken pretty seriously. Mea culpa.”

And yet even this admission, written in earnest to Frost’s closest friend, obscures as much as it reveals.

more here.

the question of animal consciousness

AnguishJohn Jeremiah Sullivan at Lapham's Quarterly:

The modern conversation on animal consciousness proceeds, with the rest of the Enlightenment, from the mind of René Descartes, whose take on animals was vividly (and approvingly) paraphrased by the French philosopher Nicolas Malebranche: they “eat without pleasure, cry without pain, grow without knowing it; they desire nothing, fear nothing, know nothing.” Descartes’ term for them was automata—windup toys, like the Renaissance protorobots he’d seen as a boy in the gardens at Saint-Germain-en-Laye, “hydraulic statues” that moved and made music and even appeared to speak as they sprinkled the plants. This is how it was with animals, Descartes held. We look at them—they seem so full of depth, so like us, but it’s an illusion. Everything they do can be attached by causal chain to some process, some natural event. Picture two kittens next to each other, watching a cat toy fly around, their heads making precisely the same movements at precisely the same time, as if choreographed, two little fleshy machines made of nerves and electricity, obeying their mechanical mandate.

Descartes’ view drew immediate controversy. Writers such as the naturalist John Ray, in The Wisdom of God Manifested in the Works of the Creation(1691), protested on behalf of “the common sense of mankind” that if “beasts were automata or machines, they could have no sense, or perception of pleasure, or pain…which is contrary to the doleful significations they make when beaten, or tormented.”

more here.

on W.G. SEBALD’S A PLACE IN THE COUNTRY

Black-sebaldColin Dickey at The Quarterly Conversation:

Though his life was tragically cut short at the height of his creative powers, W. G. Sebald has been steadily churning out work since his death. Sebald’s posthumous publications have, by and large, followed a now-standard pattern: first were the works already or nearly finished and ready for print (On the Natural History of Destruction, After Nature), then the uncollected essays which offered polished, self-contained pieces (Campo Santo), then the book of interviews, along with the books of minor poetry for which he was not primarily known (Unrecounted, Across the Land and the Water). This last, released in 2012, would seem to have been the beginning of the end of this vast reserve—Sebald’s minor poetry is interesting at times, but far below the quality of his prose works or his masterful poetic work After Nature. Reaching the end of a finite supply, it would seem that the only place left to go would be to journals, fragments of essays, or other ephemera.

Instead, 2014 sees the release in the United States of A Place in the Country: a full prose work published originally in German in 1998, between The Rings of Saturn andAusterlitz—in other words, at the height of Sebald’s literary career. The book is a series of essays on five writers (Johann Peter Hebel, Jean-Jacques Rousseau, Eduard Mörike, Gottfried Keller, and Robert Walser) and one painter (Jan Peter Tripp), the product of what he describes, in the foreword, as an “unwavering affection for Hebel, Keller and Walser,” which in turn “gave me the idea that I should pay my respects to them before, perhaps, it may be too late.” A haunting phrase, given his death only three years after the book’s publication—but one that also accurately sums up the admiration and homage that runs through the book, a writer engaging with his forebears and tracing his own literary genealogy through the past two centuries.

more here.

Rasputin: A short life

Keith Gessen in The Guardian:

Rasputin-009Grigory Rasputin was a Siberian peasant turned holy man with incredible charisma, bad teeth, questionable hygiene (he claimed that he once went six months without changing his underwear), and a strong animal odour – like a goat's (according to the French ambassador). He used these various attributes to ingratiate himself with the royal family of Russia and become, for about a year toward the end of the Romanov dynasty, the de facto power behind the throne. While doing all this he seduced thousands of women and still managed to get stone drunk several nights a week. It's an inspiring story, though it ends badly, and no wonder that the expatriated French actor Gérard Depardieu has played Rasputin in not one but two biopics in the last two years.

…Rasputin took advantage of the Russian tradition of the wandering peasant holy man, walking from village to village and reputed to have a direct connection with God (even Tolstoy, toward the end of his life, visited one). He also exploited the loneliness and isolation of the last Romanov couple, Nicholas and Alexandra – the tsar a polite, indecisive man and the tsarina a German-born and English-bred granddaughter of Queen Victoria (“The tsarina was as happy ordering chintzes from the latest Maples catalogue as she was cultivating mystics,” writes Welch), who never quite adjusted to Russian life or shed her accent (she communicated with Nicholas in English). And, finally, he made use of the vexed condition of the couple's son, Alexis, the heir to the Russian throne, who had inherited (from Queen Victoria) a terrible disease: haemophilia. Nicholas and Alexandra kept vigilant watch over the boy, employed two sharp-eyed sailors to accompany him everywhere and commandeered an army of doctors to try to make him well. None of them could do anything; as Welch points out, they may easily have done more harm than good, prescribing, for example, the new wonder drug aspirin, which we now know is an anti-coagulant, the exact opposite of what a haemophiliac needs. The disease was torture for both the boy and his mother. During bleeding episodes Alexis would suffer excruciating pain, and his mother, an empress but also, she knew, the carrier of the disease, would sit by him, helpless.

More here.

Genome sequencing stumbles towards the clinic

Erika Check Hayden in Nature:

WEB_475158105Sequencing a person’s entire genome can reveal potentially life-saving information about the presence of mutations associated with diseases. But there are drawbacks — a study published this week finds that current sequencing technology does not always capture the complete genome, and illustrates the challenges of interpreting what the results mean for an individual patient1. “There are many steps that have to be worked out to ensure that we gain the most health-care benefit,” says William Feero, a physician at the Maine Dartmouth Family Medicine Residency in Fairfield, Maine, who was not involved in the study. Researchers at Stanford University in California, examined whether a whole-genome scan could identify disease risks in healthy people — a use of the technology that is within financial reach as the cost of sequencing drops. The team of doctors, genetic counsellors and scientists report today in the Journal of the American Medical Association that it sequenced the whole genomes of 12 people with no diagnosed genetic diseases, looking for genetic mutations that might cause disease. Every patient was found to have 2–6 such mutations, and one woman found out that she carried a mutation in the gene BRCA1, which is linked to greater risk of ovarian and breast cancer. She opted to have her ovaries removed as a result.

But the researchers, led by cardiologists Euan Ashley and Thomas Quertermous, also found that between the two genome sequencing services they used — Illumina, based in San Diego, California, and Complete Genomics, based in Mountain View, California — 10–19% of genes known to be linked to disease were not adequately sequenced. So doctors might have missed finding harmful mutations in these genes. The two services also disagreed two-thirds of the time about the presence of a particularly worrisome type of mutation — the addition or deletion of parts of genes linked to disease. Deciding what these results meant for patients was not easy. The study clinicians often disagreed about what patients should do in light of the findings about their genomes — for instance, whether a particular mutation meant that the patient should undergo further testing.

More here.

Tuesday, March 11, 2014

Trespassing in the library of a dead genius

John Kaag in Harper's:

ScreenHunter_549 Mar. 11 15.44Dozens of times over the past four years, I’ve made the drive from my home in Boston to a long-forgotten library in the middle of New Hampshire, accessible only by dirt road and hidden behind White Mountain pines. It once belonged to William Ernest Hocking, the last great idealist philosopher at Harvard, and though it contains irreplaceable volumes, it was known until recently only to a few of Hocking’s relatives and one very fastidious thief. And me.

I had come to Chocorua, New Hampshire, in 2009, to help plan a conference on William James. But I’m not a particularly dedicated philosopher and in general bore easily, so I soon found myself elsewhere: specifically, considering the virtues of theSchnecken at a German pastry shop. And this is where I found, browsing the scones, a man of ninety, wiry and sharp, who introduced himself as Bun Nickerson. Nickerson moved slowly, like most old philosophers do, but unlike most old philosophers his hobble wasn’t a function of longstanding inactivity. Instead, he explained, it was from farming and professional skiing.

I’m normally hesitant to say what I do for a living — “I teach philosophy” is often prelude to awkward silence — but Nickerson found my profession intriguing, because he’d grown up in a little house on a corner of a philosopher’s land. “Doctor Hocking’s land,” as he put it. Today, philosophers have arguments, office hours, books, articles, committee meetings, and the occasional student. Few of us have “land.” Nickerson made Hocking’s sound impressive and permanent, like the proper realm of a philosopher king: one stone manor house, six smaller summer cottages, two large barns, and one fishing pond with three beaver hutches, all situated on 400 acres of field and forest. Most seductively, Nickerson mentioned a library. Getting to see it struck me as a very good reason to skip out on my conference-planning responsibilities, so I climbed into Nickerson’s pickup and we bumped our way up the hill.

More here.

Why do we listen to our favourite music over and over again?

Elizabeth Hellmuth Margulis in Aeon:

00017089What is music? There’s no end to the parade of philosophers who have wondered about this, but most of us feel confident saying: ‘I know it when I hear it.’ Still, judgments of musicality are notoriously malleable. That new club tune, obnoxious at first, might become toe-tappingly likeable after a few hearings. Put the most music-apathetic individual in a household where someone is rehearsing for a contemporary music recital and they will leave whistling Ligeti. The simple act of repetition can serve as a quasi-magical agent of musicalisation. Instead of asking: ‘What is music?’ we might have an easier time asking: ‘What do we hear as music?’ And a remarkably large part of the answer appears to be: ‘I know it when I hear it again.’

Psychologists have understood that people prefer things they’ve experienced before at least since Robert Zajonc first demonstrated the ‘mere exposure effect’ in the 1960s. It doesn’t matter whether those things are triangles or pictures or melodies; people report liking them more the second or third time around, even when they aren’t aware of any previous exposure. People seem to misattribute their increased perceptual fluency – their improved ability to process the triangle or the picture or the melody – not to the prior experience, but to some quality of the object itself. Instead of thinking: ‘I’ve seen that triangle before, that’s why I know it,’ they seem to think: ‘Gee, I like that triangle. It makes me feel clever.’ This effect extends to musical listening. But evidence has been accumulating that something more than the mere exposure effect governs the special role of repetition in music.

More here.

nonsite discusses Fredric Jameson’s new book, The Antinomies of Realism (Verso, 2013)

Antinomies_of_Realism_CMYK_300Goran Blix at nonsite:

It’s clear from Jameson’s latest book that a great deal remains to be said about the emergence and dissolution of the classical realist novel. Concepts like Auerbach’s mimesis and Bakhtin’s dialogism have hardly exhausted the problem, nor have more strictly historical accounts seeking to situate this hybrid form along a spectrum of modes and genres running from romance and epic to melodrama and modernism. Moreover, as Jameson recalls, discussions of realism sadly tend to get bogged down in narrow-minded aesthetic partisanship—realism, for or against?—as if the form could somehow intrinsically reinforce the dominant ideology through its apparent reification of existing reality, or, on the contrary, necessarily point toward the future by capturing the clashing forces working to undermine the status quo. Refreshingly, Jameson here tries to steer clear of any normative assessment and seeks to understand realism instead as a unique and fragile aesthetic constellation that flared up briefly within a larger dialectical movement, which then also ended up dissolving the form.

more here.

Jonathan Swift: His Life and His Work

683px-Jonathan_Swift_by_Charles_Jervas_detail-600x674George O'Brien at The American Scholar:

The final years of the 17th century and the early years of the 18th were turbulent times in England. The fate of the crown itself seemed to be in the balance, as did those of other institutions, Parliament and the Church of England. Yet, oddly, this period is also known as the Augustan Age of English literature—oddly, because the label connotes classical balance and proportion. And indeed such qualities are to be found in the period’s architecture as well as in the heroic couplets of its most accomplished poet, Alexander Pope. But expressions of neoclassical order were hard won, and for an idea of the challenges and complications of this decisive period in the evolution of the British polity, the life and works of Jonathan Swift are a very good place to start. Swift is not just the author of Gulliver’s Travels, though that most original and very alarming treatise on human nature would have been enough to make his name. He was also the author of a good deal of commentary, much of it bitingly satirical, on the manners and methods of the public scene in which he himself was immersed, partly in hopes of preferment. The fact that when these hopes were dashed he turned out to be an Irish patriot is only one of the many paradoxes of a career and a personality in which balance, order, establishment, and affiliation were problematic categories.

more here.

the whitney biennial

170327_r29618-690x583-1489702355Peter Schjeldahl at The New Yorker:

The work in the Biennial that you are most apt to remember, “The Meat Grinder’s Iron Clothes” (2017), by the Los Angeles artist Samara Golden, marries technique and storytelling on a grandiose scale. Golden has constructed eight miniaturized sets of elaborately furnished domestic, ceremonial, and institutional interiors. They sit on top of and are mounted, upside down, beneath tiers that frame one of the Whitney’s tall and wide window views of the Hudson River. Surrounding mirrors multiply the sets upward, downward, and sideways, to infinity. To reach a platform with a midpoint view of the work, you ascend darkened ramps, on which ominous hums, bongs, and whooshes can be heard. Concealed fans add breezes. Politics percolate in evocations of social class and function, with verisimilitude tipping toward the surreal in, for example, a set that suggests at once a beauty parlor, a medical facility, and a prison. But the work’s main appeal is its stunning labor-intensiveness: sofas and chairs finely upholstered, tiny medical instruments gleaming on wheeled carts. Golden is the most ambitious of several artists in the show who appear bent on rivalling Hollywood production design, with a nearly uniform level of skill. I’m reminded of a friend’s remark, apropos of the recent New York art fairs: “I thought I missed good art, but that’s always rare. What I miss is bad art.”

more here.

Traveling Through Palestine While Black: A Firsthand Look at a Slow-Moving Annexation

Bill Fletcher, Jr. in AlterNet:

Boy_and_soldier_in_front_of_israeli_wallIt has become almost a cliché to speak of Gaza, the Palestinian territories on the Mediterranean controlled by Hamas and blockaded by Israel, as the largest open-air prison on the planet. Yet I am not sure I will any longer agree with the limits of that characterization. The Palestinians are all in prison. While Gaza may be a maximum security facility, the West Bank is nevertheless a prison. So little is actually controlled by Palestinians despite the formal notion of autonomy. Israeli military incursions can and do happen at any time convenient for the Israeli government and its military occupation. Palestinians are prohibited from using certain roads. The ominous and illegal separation wall, better known as the apartheid wall, spreads like a disease across the land, dividing the Palestinians not as much from the Israelis as from their own land.

For all of that, it is the sense of permanent insecurity and maximum humiliation that reinforces the feeling one gets of being in a prison. There are checkpoints at seemingly every turn; one is subjected to being stopped at any time. There is an attitude of arrogance and contempt on the part of most of the Israeli military personnel. With their submachine guns and their insistence on using Hebrew in communicating with the Arabic-speaking Palestinians, they invade the space of the indigenous population, always reminding them that there is no such thing as privacy in the Occupied Territories.

More here.

Kitty Genovese

Jordan Michael Smith in The Christian Science Monitor:

KittyOkay, that last name might not be as familiar as the others. But the details of the crime are almost certainly known to you. In New York City in 1964, the 29-year-old Genovese was stabbed to death in three separate attacks as 38 neighbors watched and declined to get involved. At least, that is commonly reported version of the story. But Kevin Cook explains in his new book Kitty Genovese why this simplified version of the story is not the true one. Cook, a freelance journalist, has accessed for his book the detective’s reports of their preliminary interviews with Genovese’s neighbors. He found that, rather than including 38 eyewitnesses, the police log contained 38 entries. Writes Cook: “It was a roundup of interviews with many of Kitty’s neighbors, not a definitive accounting of anything.” Far fewer eyewitnesses actually existed, and those that did were generally fearful of getting involved, rather than indifferent to the woman. The popular figure of 38 resulted from a clerical error provided to the police chief, who passed it along to the New York Times reporter who made the case famous. It was a consequential mistake. The murder shocked Americans, who were horrified and baffled that so many onlookers refrained from intervening to assist the woman. The idea of 38 people so self-obsessed and alienated from their neighbors reflected the anxieties of many citizens, who saw rising crime, feared the Civil Rights Movement, and felt alone in an urbanized America.

CBS’s Mike Wallace narrated a segment on “The Apathetic Americans.” The murder spurred officials to create the 911 emergency-phone system. States created Good Samaritan laws. Victim-compensation laws, witness-assistance programs, neighborhood watch groups – the list of public policy changes that resulted from reaction to the case is extraordinary. Equally more remarkable has been the lasting influence the murder – particularly the false figure reported – has had in academia. One professor tells Cook that the murder is “the most-cited incident in social psychology literature until the September 11 attacks.” Cook manages to maintain an impressive level of tension in a book about a half-century old case about which everyone thinks they know the outcome. He assumes, surely correctly, that while many readers may have heard of the case, they don’t recall the specifics aside from the number of eyewitnesses. So he treats Genovese’s murder like something of a mystery – we may know that she was killed, but not why.

And who was Kitty Genovese, anyway? She was, in fact, a lesbian, a fact that likely would have drastically affected the public’s response to the crime, had it been reported at the time.

More here.