Category: Recommended Reading
Hung in Time: John Berger draws Tilda Swinton
Saturday, November 18, 2017
Baggini’s consolations for a post-truth world
Hugh D. Reynolds interviews Juliana Baggini over at 3:AM Magazine:
3:AM: In the first chapter, Eternal truths, you write: ‘One of the problems we face is not the absence of truth, but its overabundance.’ You make a case for maintaining divergence into two streams of truth: revealed, religious truths, and those more grounded in science. I can see that this is a pragmatic, perhaps vital split to reduce conflict, but isn’t it permitting a kind of truth bypass?
JB: There are lots of very sophisticated religious believers who make religion out to be a kind of primitive science – and it really isn’t. They’ll talk about Stephen J. Gould and the two Non-Overlapping Magisteria (see his Rock of Ages (Random House 1999)). I think that they are prescriptively right and descriptively wrong.
A lot of religious belief – even the majority – involves making factual claims about the world which do come into conflict with science and history. For Christians, a test of this is the Empty Tomb. I ask Christians: ‘are you saying that it does not matter – as a matter of fact – whether or not Christ’s tomb was empty and that he was resurrected?’ At that point, I find that, to a lot of them, it really does matter, despite all the fine talk about not wanting to confuse science and history with religion.
Having said that, it is the right door to push against. There are believers who are already there or half the way there. Rather than say ‘let’s forget about religion – let’s get rid of it’ – I think we should try and force people to walk the talk: to take more seriously the idea that, whatever religious truth is, it’s not the same thing as science and history. People find that easy to say, and difficult to do.
More here.
Rescuing Economics from Neoliberalism
Dani Rodrik in Boston Review:
A journalist calls an economics professor for his view on whether free trade is a good idea. The professor responds enthusiastically in the affirmative. The journalist then goes undercover as a student in the professor's advanced graduate seminar on international trade. He poses the same question: Is free trade good? This time the professor is stymied. “What do you mean by ‘good?’” he responds. “And good for whom?” The professor then launches into an extensive exegesis that will ultimately culminate in a heavily hedged statement: “So if the long list of conditions I have just described are satisfied, and assuming we can tax the beneficiaries to compensate the losers, freer trade has the potential to increase everyone's well being.” If he is in an expansive mood, the professor might add that the effect of free trade on an economy's long-term growth rate is not clear either and would depend on an altogether different set of requirements.
This professor is rather different from the one the journalist encountered previously. On the record, he exudes self-confidence, not reticence, about the appropriate policy. There is one and only one model, at least as far as the public conversation is concerned, and there is a single correct answer regardless of context. Strangely, the professor deems the knowledge that he imparts to his advanced students to be inappropriate (or dangerous) for the general public. Why?
The roots of such behavior lie deep in the sociology and the culture of the economics profession. But one important motive is the zeal to display the profession's crown jewels in untarnished form—market efficiency, the invisible hand, comparative advantage—and to shield them from attack by self-interested barbarians, namely the protectionists. Unfortunately, these economists typically ignore the barbarians on the other side of the issue—financiers and multinational corporations whose motives are no purer and who are all too ready to hijack these ideas for their own benefit.
More here.
The Trouble With Globalization
Dani Rodrik over at the Milken Institute Review:
The logic of sustaining an open economy by compensating those who end up with smaller slices of the pie is impeccable. That’s how European nations, with their extensive safety nets and generous social benefits, integrated into the world economy. To this day, despite rising populism, international trade is not a very contentious issue in Europe. Anti-globalization ire focuses not on Chinese or Mexican exporters, but on faceless bureaucrats in Brussels and Frankfurt — and, of course, on immigrants. The United States, too, could have moved aggressively to compensate dislocated workers in the 1990s, when it opened its economy to imports from Mexico, China and other low-income countries in a major way. Instead, under the sway of market fundamentalists, the United States let the chips (and workers) fall where they may.
By now, the compensation approach has been tarred as “burial insurance.” The trade adjustment assistance programs that are habitually tacked on to trade agreements have provided inadequate aid — and to just a sliver of the affected population. That is partly by design: politicians have little incentive to implement strong compensation programs once trade agreements are approved.
More here. Also see in the Milken Institute Review, this piece by Brad Delong on Globalization:
Portions of the case against globalization have some traction. It is, indeed, the case that the share of employment in the sectors we think of as typically male and typically blue-collar has been on a long downward trend. Manufacturing, construction, mining, transportation and warehousing constituted nearly one-half of nonfarm employment way back in 1947. By 1972, the fraction had slipped to one-third, and it is just one-sixth today.
But consider what the graph to the left does not show: the decline (from about 45 percent to 30 percent) in the share of these jobs from 1947 to 1980 was proceeding at a good clip before U.S. manufacturing faced any threat from foreigners. And the subsequent fall to about 23 percent by the mid-1990s took place without any “bad trade deals” in the picture. The narrative that blames declining blue-collar job opportunities on globalization does not fit the timing of what looks like a steady process over nearly three-quarters of the last century.
“Despacito” Biology Parody
on richard wilbur
Patrick Kurp at The Quarterly Conversation:
Robert and Mary Bagg have written the first biography of our greatest living poet, now age ninety-six, borrowing their title from Bogan’s prescient review of The Beautiful Changes, published seventy years ago. The Baggs draw upon previously unpublished journals, family archives, and interviews with Wilbur, his family, and friends, and these constitute the most valuable and interesting portions of the book. Wilbur is eminently quotable, in prose, verse, and conversation, but the book as a whole is a rather plodding affair. More about that below.
In an age when poets have jettisoned prosody and much verse is indistinguishable from prose, Wilbur has “remained true to his own poetic identity, refusing to develop fashionable, and usually transitory, styles,” in the words of his biographers. He has written precisely one poem in free verse, today’s lingua franca. In 2008, Wilbur told an interviewer: “The kind of poetry I like best, and try to write, uses the whole instrument. Meter, rhyme, musical expression—everything is done for the sake of what’s being said, not for the sake of prettiness.” Throughout his writing life, Wilbur has been accused of being effete, reactionary, elegant, and insufficiently transgressive and progressive. We learn from the Baggs, Wilbur was politely left-leaning as a young man, dabbled with pacifism, and has never been particularly interested in politics. Born in 1921, he served in World War II as a cryptographer with the 36th Texas Division.
more here.
how martin amis thinks
Kevin Power at the Dublin Review of Books:
So, as of 2017, the Amis Canon is still in order, with only some mild fluctuations in market value to trouble us (Updike, down ten at close; invest heavily in Bellow futures). With remarkable consistency, Amis has been praising more or less the same small group of (mostly male, definitely straight, definitely white) writers for four decades now. He even uses them to critique one another: “Bellow is quite unlike, say, Vladimir Nabokov and John Updike, to take two artist-critics of high distinction.” His critical insights are drawn from deep familiarity with a rigorously winnowed corpus. There have been no lately discovered enthusiasms; no essays in praise of younger novelists; certainly none in praise of writers from non-Anglophone countries (with the obvious, and meaningless, exception of Nabokov); and, increasingly, no full-length pieces about women writers of whatever vintage. (An essay in The Rub of Time on how Jane Austen’s novels have fared at the hands of filmmakers was originally published in The New Yorkerin 1997.) In much the same way, Amis’s critical principles, across forty years of reviewing, have remained intransigently firm. “Only connect the prose and the passion,” instructed EM Forster, at the crux of Howards End (1910). For Martin Amis, of course, the prose is the passion – or perhaps I should say, the passion is the prose.
To make Team Amis, you must be a writer, not necessarily of brilliant novels, or even of brilliant chapters, but of brilliant sentences and brilliant paragraphs. Amis’s critical method is to quote the bits he likes – the brilliant bits – and to point out why he likes them; or, conversely, to quote the bits he doesn’t like, and to point out that they are clichés.
more here.
Bob Dylan as Odysseus
Zoe Williams at The Guardian:
Does Thomas ever hear a couplet that’s a little bit trite and panic that that’s the real Dylan and the genius is just an accident? Shaking his head confidently, he replies: “Too many accidents.” In a way, the classical allusions of Dylan’s later work bring him back to his earliest roots in blues and folk, albeit in a roundabout way. “Think about melancholy – the song ‘Not Dark Yet’ ends with the singer getting near the end. But it’s just such a beautiful song. The beauty of the song is compensation for the melancholy. We’re all going to die, so how do you deal with that fact? You can believe in an afterlife, or you can focus on the beauty that the human mind can produce through art. I think that’s why, like Eliot or Dante, or my guys, Virgil, Ovid, because of his genius, he’s always hooking into poetic traditions. Gospel, folk, always folk. There are folk traditions in ancient Greece and Rome, they’re what people sing, how they deal with mortality. Take someone like Virgil, whose Eclogues is really at the root of western pastoral poetry: he has these songs, which are shepherds competing with each other, it’s a cultural reality turned into high art. Dylan could hear a song and absorb it probably within a couple of hearings. When he gave the Nobel lecture, he talks about becoming all of these characters, from the ballads, from the folk songs.”
more here.
Hidden Spring: A grassroots alliance between Israelis and Palestinians
Emily Raboteau in Orion Magazine:
IT WAS UNUSUALLY HOT FOR JUNE, and the heat was dry at the desert’s edge. The semiarid South Hebron Hills were stubbled with brown scrub and thistles and strewn with bone-colored rock. Though it was not quite summer and not yet noon, my guide, Ahmad S., estimated the temperature at thirty-seven degrees Celsius or, as my mind translated it, almost one hundred degrees Fahrenheit. “Drink,” Ahmad, a water lab technician, reminded me. I lifted my canteen to my lips and, without thinking, drained it. A first-world privilege, this—to be thoughtless about water. We were at the ankles of the West Bank, far off the utility grid, in the cab of Ahmad’s dusty truck. Ahmad, twenty-nine, Palestinian, comes from a town northwest of Hebron called Halhul. When I met him he was a newlywed. His new wife had been married once before. Because she was a divorcée, Ahmad’s brothers looked on her as used goods but he’d dissented from that point of view and married her for love. With his light-brown skin, gelled hair, gold chain, slim-fitting jeans, and Nikes he could have passed for one of the Dominican guys in my neighborhood in New York City. But apart from Ahmad’s slick look, I found nothing familiar in the desolate landscape. We may as well have been driving on an asteroid. The desert was bewildering to me as a city dweller, and not just because of its harsh quiet and the vast field of vision it offered, but also because of the pitiless way it exposed one to the sun. No buildings to offer cover or shade. No straight lines. Just rolling hills of rubble and saffron-colored dust. I felt jet-lagged, carsick, and ill at ease.
Judea, the right-wing Zionists call this place. The apostle Mark called it “the wilderness.” I couldn’t comprehend how such barren hills could sustain life. I’d been to Brazil’s Sertão, the steppes of New Mexico, and to Andalusia, in Spain, where the spaghetti westerns were filmed. None of those deserts were as dry as this. Yet to the north of us grew the vineyards of Mount Hebron, famed for its grapes since biblical times. The foothills to the west extended into Israel. To the east dropped the Jordan Valley, where the storied river, once crossed by the Israelites, bottoms out into the Dead Sea. In Israeli-settler parlance, and according to the Torah, God granted this land to the Jews.
More here.
Can you really be addicted to sex?
Emily Bobrow in The Economist:
Andrew was in his late 30s when he started feeling that his masturbation habit was getting out of control. He was indulging several times a day, while using pornography. These regular sessions were easy to schedule, as he was single and working from home. But his preoccupation with porn was getting in the way of the rest of his life. He wasn’t going out with friends or pursuing leads for work. “It inhibited my income,” he says. “It inhibited my relationships.” Feeling increasingly isolated and ashamed, Andrew tried raising these problems in therapy, but his therapist was uncomfortable talking about sex. When a friend mentioned he was going to 12-step meetings for sex addiction, he was fascinated, even relieved. It was the early 2000s and he wasn’t aware that such a thing existed. “I thought, ‘Wow, there’s this thing called sex addiction? That sounds like what I have’,” he recalls. Andrew started going to 12-step meetings and found it “tremendously useful” to have a place where he could talk about his problem and plan constructive ways to address it. He became more introspective, masturbated less and eventually stopped using porn. He felt so grateful for these changes that he decided to become a certified sex-addiction therapist himself.
For people like Andrew who are troubled by the scale or nature of their sexual desires, the notion that they are suffering from a disease can be a comforting one. After all, the sick cannot be held fully responsible for their actions; addiction blurs the line between culprits and victims. That may help explain why Harvey Weinstein, who spent decades abusing women without showing signs of remorse, is reported to have checked into sex-addiction rehab when the storm broke. Yet a growing number of therapists and addiction specialists are questioning whether these problems should be seen as an addiction at all. They argue that by pathologising certain sexual desires, we are failing to deal with the underlying causes of this behaviour. Given how often the term is bandied about in the news and on therapists’ couches, it is worth probing what we are really saying when we label someone a sex addict. More importantly, what does using this label encourage us not to explore, not to say?
More here.
Friday, November 17, 2017
Daniel C. Dennett: A Difference That Makes a Difference
Daniel C. Dennett at Edge.org:
Having turned my back on propositions, I thought, what am I going to do about this? The area where it really comes up is when you start looking at the contents of consciousness, which is my number one topic. I like to quote Maynard Keynes on this. He was once asked, “Do you think in words or pictures?” to which he responded, “I think in thoughts.” It was a wonderful answer, but also wonderfully uninformative. What the hell’s a thought then? How does it carry information? Is it like a picture? Is it iconic in some way? Does it resemble what it’s about, or is it like a word that refers to what it’s about without resembling it? Are there third, fourth, fifth alternatives? Looking at information in the brain and then trying to trace it back to information in the genes that must be responsible for providing the design of the brain that can then carry information in other senses, you gradually begin to realize that this does tie in with Shannon-Weaver information theory. There’s a way of seeing information as "a difference that makes a difference," to quote Donald MacKay and Bateson.
Ever since then, I’ve been trying to articulate, with the help of Harvard evolutionary biologist David Haig, just what meaning is, what content is, and ultimately, in terms of biological information and physical information, the information of Shannon and Weaver. There’s a chapter in my latest book called “What is Information?” I stand by it, but it’s under revision. I’m already moving beyond it and realizing there’s a better way of tackling some of these issues.
More here.
Notes on the Global Condition: Of Bond Vigilantes, Central Bankers, and the Crisis 2008-2017
Adam Tooze over at his website:
In May 2009 as the scale of the fiscal shock became clear, Bloomberg and the Wall Street Journalreported that markets were up in arms. Yardeni was once more to the fore warning that “Ten trillion dollars over the next 10 years is just an indication that Washington is really out of control ….” On May 29 2009 the WSJ announced that in light of “Washington’s astonishing bet on fiscal and monetary reflation” the bond vigilantes were swinging back into the saddle. “It’s not going too far to say we are watching a showdown between Fed Chairman Ben Bernanke and bond investors, otherwise known as the financial markets.” “When in doubt,” the Journal advised its readers, “bet on the markets.” It was a message that had particular resonance inside an Obama administration staffed by veterans of the Clinton years and haunted by memories of the 1990s. In May 2009 Obama commissioned his budget director Peter Orszag to prepare contingency plans for a bond market sell off. Orszag was a protégé of Clinton-era Treasury Secretary Robert Rubin. In the locust years of the Bush Presidency, Orszag had worked with Rubin to craft an agenda of budget consolidation for the next Democratic Presidency.
In early 2010 the appearance of “Growth in a time of debt”, a highly influential paper by Professors Carmen Reinhart and Ken Rogoff, added intellectual weight to fear of the bond market. The two former IMF economists claimed to have identified a critical threshold. When debt reached 90 percent of GDP, growth declined sharply leading to a vicious downward spiral. As Reinhart and Rogoff warned: once debt reached critical levels towards 90 percent of GDP or above, there was always a risk of a sudden shift in market attitudes. “I certainly wouldn’t call this my baseline scenario for the U.S”, Reinhart admitted in one interview – “but the message is: think the unthinkable.” On Fox TV historian Niall Ferguson invoked the collapse of the Soviet Russia to make the same point. A world power could be brought down by financial excess with catastrophic speed. Ferguson’s message to American audiences was stark: “The PIIGS R US”.
More here.
The idea of the humanities
Simon During over at academia.edu:
Why is it just now that a need is felt for courses on the humanities as such, and why, too, are histories and defences of the humanities pouring from the presses? As we all know, a good part of the answer is that the humanities are currently under financial and ideological pressure. This has had the effect of flattening them—by which I mean that the humanities are often no longer so much regarded as a suite of specialized disciplines but rather as a distinct formation on their own account. When, for instance, politicians, business people and university administrators worry that the humanities are insufficiently geared toward training students for the workplace they usually don’t distinguish between history, philosophy, archaeology and so on—it is simply the humanities that are in their sights, and, from that perspective, we—students and teachers— are “in the humanities” rather than in a particular discipline. We might say, in sum, that the humanities are becoming a “meta-discipline.” For all that, a concept of the humanities that transcends or,at any rate, overflows the established disciplines is a beast that has been vaguely denoted rather than concretely apprehended.
The spread of populism in Western countries
Luigi Guiso, Helios Herrera, Massimo Morelli, and Tommaso Sonno in Vox.eu:
Several studies have addressed the issue of populism recently. Algan et al. (2017) study the political consequences of the Great Recession in Europe, documenting that in post-2008 elections, EU regions experiencing higher unemployment gave more support to populists. They also document that regions where unemployment rose experienced the sharpest decline in trust in institutions and traditional politics. Dustman et al. (2017) report similar results, showing that in the aftermath of the crisis, mistrust towards European institutions – largely explained by worse economic conditions in Eurozone countries – is positively correlated with populist voting. Foster and Frieden (2017) nuance this result using individual characteristics from the Eurobarometer survey data, and also show how the link between mistrust and populism is more pronounced in debtor countries. Inglehart and Norris (2016) observe that cultural variables affect the decision to vote for a populist party (instead of abstaining or voting for a non-populist party) more than economic variables. But their finding of a weak direct effect of economic variables is due to the fact that they fail to observe that economic security shocks significantly affect the incentive to abstain, which is instead the key intermediate channel that we emphasise in our research.
Beside the fact that these studies do not consider the crucial role of the incentive to abstain from voting, the other distinguishing feature of our work is the balanced effort to understand both demand and supply of populism, rather than focusing exclusively on the demand side. Rodrik (2017) is the only recent paper that focuses on the supply side. He traces the origin of today’s populism (mainly, if not uniquely) back to the globalisation shock, arguing that past history as well as economic theory imply that waves of globalisation can predictably lead to a populist backlash with a specific timing (when the shock hits) and geographical pattern (in countries that are most adversely affected by globalisation).
More here.
When evolution is not a slow dance but a fast race to survive
Wendy Orent in Aeon:
We think of evolution, described by Charles Darwin in 1859, as a slow dance: nature chooses the best-adapted organisms to reproduce, multiply and survive in any given ecosystem. As organisms adapt to changing ecological circumstances over millennia, the varieties best-suited to the environment thrive, allowing species to emerge and evolve. This is the process known as natural selection, or differential reproduction, which simply means that the organisms best-adapted to their particular, immediate circumstances will pass on more genes to the next generation than their less-well-adapted conspecifics (members of the same species).
Permanent change, of the kind we see in the fossil record, takes more time. Just look at the plodding trajectory of the several-hoofed Hyracotherium, a dog-sized forest-dwelling mammal that gradually lost its side toes (four on the front legs and three on the back) as the central one enlarged. It took 55 million years for it to evolve into the large, single-hoofed, grass-feeding horse we know today.
But sometimes evolution happens fast. As the biologists Peter and Rosemary Grant at Princeton University in New Jersey showed in their studies of Galapagos finches, small beaks can change into large beaks in a single generation, depending on climate conditions and the type of food to be found on those harsh islands. The small-beaked birds might die out, while the large-beaked prevail, for a while at least. But those rapid changes aren’t often permanent. Though the Grants might have witnessed the evolution of an entirely new, heavy-bodied finch species, many of the changes they saw in finches’ beaks were reversed, again and again. Changes in vegetation could mean that large beaks become a handicap. This shifting process – small changes over short periods of time – is called ‘microevolution’.
The evolutionary biologists David Lahti of Queens College at the City University of New York and Paul W Ewald of the University of Louisville both argue that there’s nothing exceptional about fast evolution.
More here.
Are we condoning the conduct of Hollywood’s tyrants by watching their films?
Xan Brooks in The Guardian:
If modern day Hollywood has a Harry Lime figure, it is surely Harvey Weinstein, another hubristic monster who played by his own rules. Weinstein, sources say, would typically explain his volcanic temper and voracious appetites as being all part and parcel of his “passion for movies”. This implied that the ends always justified the means – even if the means were compulsive sexual harassment, and allegedly worse; even if the end was a film like Madonna’s W.E. Ultimately, he was no more a great artist than smirking Lime. And yet Weinstein’s fall has cast the whole industry in an ugly light. It’s like directing a UVA lamp at a crime scene. That gleaming interior is thick with thumbprints, blood and semen.
Weinstein’s disgrace is still rolling news. It remains to be seen where more evidence is uncovered and which other film-makers get caught in the net. Beauchamp hopes that the repercussions will prompt a wider societal shift. Failing that, it may result in a few repeat offenders being abruptly scared straight.
“Fear is the operative emotion in this town,” she says. “And the priority is always the next quarter’s bottom line. Right now, after Weinstein, everybody’s floundering, looking over their shoulder. If it’s because of fear that some people will stop intimidating other people, then that’s good, I’ll accept it. At least it means that they’re stopping.”
So what should we choose – cuckoo clock or Renaissance? Alternatively we could agree that the distinction is false.
More here.
Michel Foucault – Discourse and Truth
my literary apprenticeship with Ruth Prawer Jhabvala
Anita Desai in The Guardian:
Alipur Road was a wide avenue lined with enormous banyan trees, and my mother and I would go for walks along it – to Maiden’s Hotel, which had a small library, or further on to the Quidsia Gardens. And, across the road, I’d see a young woman pushing a pram with a baby seated in it and a little girl dancing alongside it. She was a married woman clearly, and I a student at the University of Delhi, but glancing across the road at her, I felt an instinctive relation to her. Why? She was revealed to be a young woman of European descent – German and Polish – who was married to an Indian architect, Cyrus Jhabvala, and lived in rooms in a sprawling bungalow just off Alipur Road. When her mother, a German Jewish woman from London, visited her, Ruth searched for someone she could talk to. I think it might have been Dr Charles Fabri, the Hungarian Indologist who lived in the neighbourhood, who suggested she might meet my German mother, who had also come to India on marrying an Indian, 30 years before, in the 1920s. A coffee party – a kaffeklatsch – was arranged so the two could indulge in their shared language in this foreign setting. I can’t imagine how or why, but Ruth decided to follow their meeting, after her mother had returned to England, with many others, on a different level – that of daughters. With extraordinary kindness and generosity she would have me over to their house, one filled with books, the books she had brought with her from England where she had been a student at the University of London when she had met Jhab. Perhaps it touched her that I was so excited about being among her books, talking to her about books. After that whenever I came away with an armful of books on loan, with her talk still in my ears, I felt elated, a visitor to another world, the writers’ world I had only imagined and now proved real. I would go home to scribble at my desk with a new, unaccustomed sense of the validity of such an occupation.
…Ruth became ill, her family worried about her. In those days if she ever saw I was myself going through some anguish over life or writing, she would not question or probe but instead rally me – and perhaps herself – by quoting Thomas Mann: “He is mistaken who believes he may pluck a single leaf from the laurel tree of art without paying for it with his life,” or asking, laughingly, “What would you rather be – the happy pig or the unhappy philosopher?” making light of it but not taking it lightly herself. It must have been at this time that James Ivory and Ismail Merchant entered her life when they came to India in search of material for a film. They found it in an early novel of hers, The Householder, which she adapted for the screen for them. She said “Films made a nice change for me. I met people I wouldn’t have done otherwise: actors, financiers, con men,” and moved to New York, buying an apartment on the Upper East Side where Ismail and Jim lived.
More here.
The Unbearable Weirdness of CRISPR
Veronique Greenwood in Nautilus:
When Francisco Mojica was 25, he supported himself by tracking bacteria in the Mediterranean off the coast of a tourist haven in southeastern Spain. At the time, he was a doctoral candidate at the University of Alicante, where he focused on a much stranger microorganism than those he was searching for in the ocean: Haloferax mediterranei, a single-celled creature that thrives in water so salty it kills almost everything else. “Even sea water is not salty enough for them,” he says. To understand this peculiar creature, Mojica, his advisor, and another graduate student were painstakingly sequencing bits of H. mediterranei DNA. This was the early 1990s—pre-Human Genome Project, pre-modern genomics—and it was frustrating work. When Mojica found bizarre, stuttering repeats of DNA bases, he assumed they’d screwed up somehow. “It’s impossible that you get exactly the same sequence many times!” he recalls thinking. But every time Mojica and his colleagues repeated the experiment, the same pattern—30 or so bases that appeared over and over again, separated by lengths of seemingly unrelated DNA—reappeared. Reading journal articles in the library, Mojica learned that a Japanese group had noticed something similar in the genome of E. coli a few years before. Despite the fact that the repetitions did not seem to be connected to H. mediterranei’s predilection for salt, he put a chapter on them at the end of his Ph.D. thesis. And by the time he turned the thesis in, he couldn’t stop thinking about them. There weren’t many people who shared his interest. Unexplained oddities are common in the genomes of most organisms, from humans to archaea, the group of microorganisms to which H. mediterranei belongs. Even after moving on to other subjects, Mojica remained fascinated by the fact that E. coli and H. mediterranei, which were only distantly related, both had repeats—and that the “spacer DNA” between the repeats was always about the same length despite having a wide variety of different sequences. What were these things for?
In 1994, between a pair of short-term positions, he returned to these single-celled curiosities and inserted extra copies of the repeats and spacers into H. mediterranei to see what would happen. The cells promptly died—“It was amazing!” he recalls fondly—and he wrote a paper suggesting the extra copies interfered with the cells’ ability to reproduce correctly. (He was wrong.) After he was hired to teach at University of Alicante in 1997, he tried, fruitlessly, to see if the same thing would happen in E. coli. Perhaps the repeats formed small loops in the genome for proteins to attach to? (Wrong again.) “Nothing worked,” he says. Still, in the years since he’d started his work, genome sequencing had gotten much easier. By the early 2000s, other people were starting to wonder about both the patterns that had intrigued Mojica and the genes around them, including Roger Garrett at the University of Copenhagen, Ruud Jansen at Utrecht University in the Netherlands, and Eugene Koonin at the Unites States’ National Center of Biotechnology Information (NCBI). When Mojica and Jansen struck up a correspondence, they began tossing around catchy names for the patterns, and on Nov. 21, 2001, they settled on CRISPR—an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. Mojica finally found the key that was to unlock the origin of the spacers, and, along with it, the meaning of the puzzle that had transfixed him for so long, in 2003. While studying E. coli, he realized that the spacers were pieces of DNA from viruses that were retained in the genome of the host species—and that some of the microbial strains that carried the spacers were either already known to be resistant to infection or had no record of ever being infected.
More here.
