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Category: Archives
Scientists’ and engineers’ bold ideas are creating a safer, more prosperous planet
From Discover Magazine:
Cultivating Safer Food Sources
Engineered cell therapy for cancer gets thumbs up from FDA advisers
Heidi Ledford in Nature:
External advisers to the US Food and Drug Administration (FDA) have thrown their support behind a therapy that genetically engineers a patient’s own immune cells to target and destroy cancer cells. In a unanimous vote on 12 July, the panel determined that the benefits of the treatment, called CAR-T therapy, outweigh its risks. The vote comes as the agency considers whether to issue its first approval of a CAR-T therapy — a drug called tisagenlecleucel that's manufactured by Novartis of Basel, Switzerland. The FDA is not obligated to follow the recommendations of its advisers, but it often does.
Novartis is seeking approval to use tisagenlecleucel to treat children and young adults that have a form of acute leukaemia, and who have not sufficiently responded to previous treatment or have relapsed since that treatment. In the United States, about 15% of children and young adults with acute leukaemia relapse following treatment. Studies have shown that CAR-T therapies can produce lasting remissions in such cases. In one key trial of tisagenlecleucel, which started in 2015, 82.5% of 63 patients experienced overall remissions. The trial lacked a control group, so investigators cannot yet say with certainty how much of an effect the treatment had. But many of those participants have remained cancer free for months or years. Many of the FDA's advisers were effusive in their praise. "This is a major advance, and is ushering in a new era," said Malcolm Smith, a paediatric oncologist at the National Institutes of Health in Bethesda, Maryland. Timothy Cripe, an oncologist at Nationwide Children's Hospital in Columbus, Ohio, called it one of the most exciting things he has seen in his lifetime.
More here.
Wednesday, July 12, 2017
Why are so many smart people such idiots about philosophy?
Olivia Goldhill in Quartz:
There’s no doubt that Bill Nye “the Science Guy” is extremely intelligent. But it seems that, when it comes to philosophy, he’s completely in the dark. The beloved American science educator and TV personality posted a video last week where he responded to a question from a philosophy undergrad about whether philosophy is a “meaningless topic.”
The video, which made the entire US philosophy community collectively choke on its morning espresso, is hard to watch, because most of Nye’s statements are wrong. Not just kinda wrong, but deeply, ludicrously wrong. He merges together questions of consciousness and reality as though they’re one and the same topic, and completely misconstrues Descartes’ argument “I think, therefore I am”—to mention just two of many examples.
And Nye—arguably America’s favorite “edutainer”—is not the only popular scientist saying “meh” to the entire centuries-old discipline. Astrophysicist Neil DeGrasse Tyson has claimed philosophy is not “a productive contributor to our understanding of the natural world”; while theoretical physicist Stephen Hawking declared that “philosophy is dead.”
It’s shocking that such brilliant scientists could be quite so ignorant, but unfortunately their views on philosophy are not uncommon.
More here.
Earth’s sixth mass extinction event under way, scientists warn
Damian Carrington in The Guardian:
A “biological annihilation” of wildlife in recent decades means a sixth mass extinction in Earth’s history is under way and is more severe than previously feared, according to research.
Scientists analysed both common and rare species and found billions of regional or local populations have been lost. They blame human overpopulation and overconsumption for the crisis and warn that it threatens the survival of human civilisation, with just a short window of time in which to act.
The study, published in the peer-reviewed journal Proceedings of the National Academy of Sciences, eschews the normally sober tone of scientific papers and calls the massive loss of wildlife a “biological annihilation” that represents a “frightening assault on the foundations of human civilisation”.
Prof Gerardo Ceballos, at the Universidad Nacional Autónoma de México, who led the work, said: “The situation has become so bad it would not be ethical not to use strong language.”
Previous studies have shown species are becoming extinct at a significantly faster rate than for millions of years before, but even so extinctions remain relatively rare giving the impression of a gradual loss of biodiversity. The new work instead takes a broader view, assessing many common species which are losing populations all over the world as their ranges shrink, but remain present elsewhere.
More here.
When Is A Sandwich Not Just A Sandwich?
Rod Dreher in The American Conservative:
A lot of people are ragging on David Brooks today for this passage in his column about how elite culture effectively closes the door on non-elite Americans:
Recently I took a friend with only a high school degree to lunch. Insensitively, I led her into a gourmet sandwich shop. Suddenly I saw her face freeze up as she was confronted with sandwiches named “Padrino” and “Pomodoro” and ingredients like soppressata, capicollo and a striata baguette. I quickly asked her if she wanted to go somewhere else and she anxiously nodded yes and we ate Mexican.
Ha ha! Get a load of that David Brooks! they say. But here’s how the column continues:
American upper-middle-class culture (where the opportunities are) is now laced with cultural signifiers that are completely illegible unless you happen to have grown up in this class. They play on the normal human fear of humiliation and exclusion. Their chief message is, “You are not welcome here.”
In her thorough book “The Sum of Small Things,” Elizabeth Currid-Halkett argues that the educated class establishes class barriers not through material consumption and wealth display but by establishing practices that can be accessed only by those who possess rarefied information.
To feel at home in opportunity-rich areas, you’ve got to understand the right barre techniques, sport the right baby carrier, have the right podcast, food truck, tea, wine and Pilates tastes, not to mention possess the right attitudes about David Foster Wallace, child-rearing, gender norms and intersectionality.
Brooks is right about that, and it was good of him to use that example, however trivial it might sound. The fact that so many snarky commenters don’t understand why something as small as this matters reveals their insensitivity to the phenomenon.
More here. [Thanks to Ali Minai.]
Clock created by renowned Dutch designer Maarten Baas
This clock at Amsterdam Schiphol Airport was created by renowned Dutch designer Maarten Baas. It features video of a man in a work uniform painstakingly painting the time minute by minute.
Baas was inspired by “the many faceless men who sweep, clean and work at an airport in their blue overalls.”
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The diaries of Susan Sontag
Melissa Anderson at Bookforum:
“MY DESIRE TO WRITE is connected with my homosexuality. I need the identity as a weapon, to match the weapon that society has against me,” Sontag wrote on December 24, 1959, the year she divorced Philip Rieff, whom she married when she was seventeen, in 1950, and whom she identifies in this same entry as her “enemy.” She ends that day’s observations with this: “Being queer makes me feel more vulnerable. It increases my wish to hide, to be invisible—which I’ve always felt anyway.”
A few years later, her critical—public—language began to make visible the invisible, disclosures sometimes marked by anxious disavowals. In “Notes on ‘Camp,’” first published in 1964 and collected in her inaugural collection of criticism, Against Interpretation and Other Essays (1966), Sontag meticulously distills a gay (male) sensibility, only to offer this strange repudiation: “Yet one feels that if homosexuals hadn’t more or less invented Camp, someone else would.” The essay that gives this volume its title, also first appearing in 1964, however, more boldly situates its author as a voluptuary. The famous conclusion to “Against Interpretation”—“In place of a hermeneutics we need an erotics of art”—might be thought of as a corollary to what Sontag recorded in a 1965 diary entry: “Every art incarnates a sexual fantasy—” This maxim would include, especially, the seventh art; both Reborn and As Consciousness contain prodigious lists of films Sontag had viewed in just a matter of days or weeks. She would worry, decades later, that the ceremonies of the cine-sensualist were near extinction. “
more here.
The World-Spanning Humanism of Mohsin Hamid
Eli Jelly-Schapiro at The Millions:
Mohsin Hamid’s new novel Exit West begins in an unnamed city fractured by political violence. There, two young people come together as everything around them is breaking apart. Nadia is a cultural rebel who wears a full black robe, “so men don’t fuck with [her]” as she traverses the city on her motorcycle. Saeed is a devoted son who wears “studiously maintained stubble” and passes quiet evenings on the balcony, gazing out at the city rather than immersing himself in it. Before these patient lovers make the exit promised by the novel’s title, and compelled by the tightening grip of civil war, Nadia ventures beyond the city through her phone, which she rides into and over the world, watching “bombs falling, women exercising, men copulating, waves tugging at the sand like the rasping licks of so many mortal, temporary, vanishing tongues.” Registering both brutality and beauty, the planetary sight that Nadia simulates here mirrors that aspired to by Hamid’s powerful book.
The novel traces Nadia and Saeed’s journey from their home city to the island of Mykonos, to London, and finally to the hills of California — a route of escape if not liberation enabled by a series of magical doors, portals that highlight through omission the unrepresentable terror of the passages in between. Progress through them — which is “both like dying and like being born” — is attained not just by the novel’s protagonists but by several people its panoramic vision only ephemerally registers: a man with “dark skin and dark, wooly hair” struggles out of a closet door in Sydney; two Filipina women emerge from a disused door at the rear of a bar in Tokyo; a young woman slips out of a black door in a Tijuana cantina; a Tamil family wanders out of an interior service door below a cluster of “blond-and-glass” luxury towers in Dubai.
more here.
Vinyl.Album.Cover.Art
Jonathan Meades at Literary Review:
The 12-inch 33rpm vinyl LP began to oust the 45rpm single in the later 1960s. Peter Blake’s endlessly imitated design for the cover of the Beatles’ Sgt Pepper’s Lonely Hearts Club Band and Andy Warhol’s banana for The Velvet Underground & Nico were as inspired as the music itself, and inseparable from it. These were, however, exceptions to the general rule that the cover should be little more than a flattering publicity shot, even if those depicted were dressed in Alphonse Mucha’s clothes. During the bad-hair decade and a half of its existence, from 1967 to 1982, the prolific design studio Hipgnosis seldom succumbed to flattery. Instead it relentlessly exploited the freedom and limits of the format in multitudinous ways.
It shunned the creation of a house style or ‘signature’. The quality of the work collected here is, then, inconsistent. If you are the kind of artist who insists on starting from zero over and again, it is inevitable that there will be failures. Nevertheless, the triumphs are many. As much as, or perhaps even more than, any of the musicians and borderline-psycho gangster-managers who gave them pretty free rein, Aubrey Powell (who answers to the name ‘Po’), the late Storm Thorgerson and the late Peter Christopherson embellished their era with a mix of thefts, ‘appropriations’ and so on.
At their best they created utterly memorable and oddly moving images. Whenever they could, they did something other than litter their work with mugshots of hirsute interchangeables. The images they created were swift, crisp, neat.
more here.
How to Plant a Tree in the Desert
Russell Shorto in The New Yorker:
President Trump’s decision to pull the United States out of the Paris climate accord was perplexing to Europeans for many reasons, not least of which was their determination that climate change represents a for-profit opportunity. In particular, the Dutch, who more or less invented water management in Europe, a millennium or so ago, have developed a specialty in climate-change-related innovation. Four years ago, Jurriaan Ruys was a partner at McKinsey, focussing on global sustainability issues. The Dutchman had been an environmentalist since the age of eight, when he went door to door handing out stickers to save the sea turtles, but he became frustrated by the abstract nature of his work—flying around the world, advising governments on long-term climate strategy. Eventually, he up and quit. Ruys had trained as an engineer, and he was convinced that the current moment, thanks in part to instantaneous communication, was one in which grassroots solutions to yawning environmental problems could yield results. He decided to focus on desertification, which is both a symptom and an intensifier of climate change. It’s also one of the most multilayered problems on Earth, the results of which lead to human misery, political strife, and war. For the next year, Ruys hunkered down in a storage space, tinkering furiously, making frequent trips to the local hardware store.
The result of this freelance engineering is a low-tech invention that is succeeding beyond Ruys’s expectations. Three years after he emerged with his prototype, his invention has been adopted in Mexico, Cameroon, Malawi, Peru, Chile, Spain, Italy, Greece, Israel, China, Dubai, and the U.S. The company he formed, Land Life, with Eduard Zanen, an entrepreneur, has twenty employees who are working with the U.N., the World Wildlife Fund, the Los Angeles Department of Water and Power, the U.S. National Park Service, and in remote villages and refugee camps. José Luis Rubio, the vice chair of the European Soil Bureau Network, called Ruys’s invention “remarkable” in its results and told me that it represents “an innovative method” to restoring vegetation to barren landscapes.
More here.
Live-in grandparents helped human ancestors get a safer night’s sleep
From Phys.Org:
Tuesday, July 11, 2017
“Goodbye, Vitamin” May Be the Best Novel You’ll Read This Summer
Julia Felsenthal in Vogue:
“At no point have I ever been able successfully to keep a diary,” Joan Didion once wrote. “My approach to daily life ranges from the grossly negligent to the merely absent, and on those few occasions when I have tried dutifully to record a day’s events, boredom has so overcome me that the results are mysterious at best.”
Her essay is called “On Keeping a Notebook,” and Didion, to be clear, kept one (perhaps still does)—a place to document not what happened to her, but “how it felt to be me,” scraps of experience, sometimes factual, sometimes embroidered. A recipe for sauerkraut evokes the coziness of a boozy, rainy day on Fire Island; the sense memory of cracked crab for lunch as a child makes her “see the afternoon all over again,” no matter that the crab was almost certainly fictitious. These are reminders not of life, but of Joan. “I think we are well advised,” Didion observed (cannily enough to be endlessly quoted), “to keep on nodding terms with the people we used to be, whether we find them attractive company or not.”
In 2008, writer Rachel Khong began keeping a food log, a list of every meal she consumed. She was inspired in part by Robert Shields, keeper of the world’s longest diary, who recorded the goings-on of his life at five-minute intervals (to the tune of 37.5 million words). Khong hoped that by diligently tracking what she ate, she would open up a channel in her brain to remembering more: where she was; who she was with; how she was feeling. At the time she was reeling from a breakup, contending with the way a tanking relationship exposes a chasm between each partner’s memories of seemingly joint experiences. How can a person trapped in the morass of imperfect recall identify true north without signposts? “I’m terrified of forgetting,” Khong admitted in a 2014 essay that appeared in Lucky Peach, the food magazine where until recently she was an editor. “If I could remember everything, I thought, I’d be better equipped; I’d be better able to make proper, comprehensive assessments—informed decisions. But my memory had proved itself unreliable, and I needed something better. Writing down food was a way to turn my life into facts: If I had all the facts, I could keep them straight. So the next time this happened I’d know exactly why—I’d have all the data at hand.”
More here.
The End of Economics
Matt Seybold in the Los Angeles Review of Books:
Tired and slightly toasted after a long and draining dinner party, Virginia Woolf nevertheless kept a promise to her diary, recording her impression of the evening while it was still fresh. Fellow novelist Elizabeth Bowen arrived very late — “rayed like a zebra, silent and stuttering” — leaving Woolf the lone woman at a table ringed with notoriously self-assured men. This, combined with her fatigue, may explain why her account of their conversation was curt and occasionally cruel. T. S. Eliot, she wrote, was “like a great toad with jeweled eyes.” Her nephew, poet Julian Bell, was “trivial: like dogs in their lusts.” Even John Maynard Keynes, for whom she held an enduring affection, she portrayed on this occasion as bloviating and hypocritical. After mocking Christian rituals, Keynes, perhaps lightly lubricated himself, reminisced at length about a chapel ceremony held in his honor at King’s College. Woolf’s question — “Did this society, this coming together move [you?]” — is the elocutionary equivalent of an exasperated eye-roll. [1]
The dinner was held explicitly to discuss Eliot’s After Strange Gods: A Primer of Modern Heresy (1934), which collected a series of lectures given the previous year at University of Virginia. Keynes, at the time among Britain’s most prominent public intellectuals, was preparing for his own trip to the United States, during which he would reassert himself as an “economic heretic” and preview his work-in-progress, The General Theory of Employment, Interest, and Money (1936). Eliot had recently conceded that they were living “in the age of the economist” when even poets were “compelled to think about economics,” so it was, perhaps, inevitable that the discussion would turn after dinner to what Woolf called “the economic question.” “This worst of all,” she wrote, “and founded on a silly mistake of old Mr. Ricardo’s which Maynard given time will put right. And then there will be no more economic stress, and then — ?”
It is hard to know how to read this lacuna in Woolf’s account. Is her faith that Keynes could eliminate “economic stress” sincere or sarcastic? Is she reflecting Keynes’s own ambivalence about utopian prognostications? In either case, her impression that Keynes was working on an audacious political economy designed to save the world from audacious political economy perfectly encapsulates a central paradox of Keynesianism, as elucidated by Geoff Mann’s In The Long Run We Are All Dead: Keynesianism, Political Economy and Revolution (2017). Keynes expected The General Theoryto radically remake his profession, though not in the ways Mann demonstrates it has. In Mann’s account, Keynesianism ultimately helped sever economists from their own rich tradition of heretical political philosophy and reduced them to platitudinous apologists for plutocracy.
More here.
Do apes produce metonymies?
Dan Sperber in Cognition and Culture:
Your friend Olga is coming for a drink. You put two plates on the table, one with olives and the other with almonds. When both plates have been emptied, you ask Olga, “Do you want anything else?” “Yes, please!”, she answers, pointing to the plate where the almonds had been. What is she requesting? The empty plate? Of course not. She is requesting more almonds. To do so, she uses a gestural metonymy: pointing to a container to convey something about its (past) content.
Container-for-content metonymies are quite common in language use. Typical examples are: “I just had one glass” or “the school bus was singing.” Some of these gestural or verbal metonymies have become conventional but we can produce or understand novel ones without effort. What communicative abilities does it take to make use of metonymies? Could a 12-month-old child, who does not yet speak, spontaneously produce an appropriate gestural metonymy? For that matter, could an ape?
In his doctoral work at the Max Planck Institute for Evolutionary Anthropology, Manuel Bohn asked an even more basic question: can infants and apes refer to absent entities? (See also earlier work by Liszkowski et al 2009; Lyn et al 2014). The capacity to do so is generally linked to the possession of language, so showing that they can would be an interesting challenge.
In one study (Bohn et al 2015), Bohn presented apes (chimpanzees, bonobos, gorillas, and orangutans) with two plates each containing three pieces of food: grapes (a higher quality food for apes) on one plate, and pieces of carrot (a lower quality food) on the other plate. The apes could point to one or the other plate and would be given a piece of food from it. As soon as a plate was emptied, the experimenter would take it out of the room and bring it back refilled.
In the critical test trials, however, the experimenter let the plates go empty without refilling them. Would the apes point to a now empty plate (as your friend Olga did)?
More here.
Can The Handmaid’s Tale Change People’s Political Views?
From Wired:
Hulu's adaptation of Margaret Atwood’s The Handmaid’s Tale is a dystopian thriller in which a Christian theocracy overthrows the US government and forces fertile women to bear children for high-ranking government officials. It’s a premise that, reviewer Beth Elderkin notes, men find imaginative or improbable and women see as chillingly real.
“We’re afraid of our power being taken away,” Elderkin says in Episode 263 of the Geek’s Guide to the Galaxypodcast. “That’s something that’s happened over and over again for thousands of years—women’s power has been taken away, largely by men, who don’t understand, or don’t want to understand, what we’re capable of.”
Writer Sara Lynn Micheneragrees that the show hits close to home. She says that’s no coincidence, since Atwood based everything in the story on real historical events.
“It is not irrational for us to fear this, given that these are things that you can find in other cultures, or in our culture in different periods, or in our culture in the present,” she says.
Michener, who was raised by conservative Christians, wishes more people from that community would watch The Handmaid’s Tale, which she thinks might cause them to question some of their more extreme views.
“If anything can slip through it’s going to be the art,” she says. “Because the rhetoric is already so divisive the stories are the thing that really have the power to penetrate those ideologies.”
More here.
Qawwali “Rang” sung by Rahat Fateh Ali Khan & the late Amjad Sabri
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The Book That Predicted Trump’s Rise Offers the Left a Roadmap for Defeating Him
Conor Friedersdorf in The Atlantic:
Rorty wasn’t dismissing bigotry as unimportant. He was quick to praise the post-’60s Left for being attentive to racial injustice and recognizing that sadism against minority groups would have persisted even apart from economic inequality. Still, he criticizes the identity politics of the left for developing a politics “more about stigma than about money, more about deep and hidden psychosexual motivations than about shallow and evident greed,” because many of the dispossessed are thereby ignored.
For Rorty, a Left that neglects victims of economic selfishness will not only fail; its neglect of class will trigger a terrible backlash that ultimately ill-serve the very groups that Leftist identity politics are intended to help. “The gains made in the past forty years by black and brown Americans, and by homosexuals, will very likely be wiped out,” he worried. “Jocular contempt for women will come back into fashion. The words ‘nigger’ and ‘kike’ will once again be heard in the workplace. All the sadism which the academic Left has tried to make unacceptable to its students will come flooding back. All the resentment which badly educated Americans feel about having their manners dictated to them by college graduates will find an outlet.”
More here.
The Art at the End of the World
Heidi Julavits in The New York Times:
We were taking an airplane, I told our children, to see what I dramatically billed as ‘‘the end of the world.’’
‘‘Can’t we go to a beach?’’ they asked. It was February. They were sick of the cold.
I promised them sand and plenty of water, but unless things went terribly wrong, we would probably not be swimming in it.
‘‘Where are we going?’’ they asked.
We were flying 2,000 miles to see more than 6,000 tons of black basalt rocks extending 1,500 feet into the Great Salt Lake in the shape of a counterclockwise vortex, designed by the most famous practitioner of ’70s land art, Robert Smithson.
‘‘It’s called the ‘Spiral Jetty,’ ’’ I told them.
I showed them pictures. I admitted that maybe ‘‘the end of the world’’ wasn’t the best way to advertise what I hoped we would experience, even though previous visitors had described the landscape as hauntingly spare, as resembling how our planet might appear following a nuclear holocaust. Smithson’s gallerist, Virginia Dwan, said the jetty ‘‘was something otherworldly, but I hesitate to say hell, because I don’t mean everybody being tortured and so forth, but the feeling of aloneness, and of it being in a place that was unsafe, and something devilish, something devilish there.’’
Adding to the excitement I presumed we now shared: The road conditions near the jetty were highly variable, which was to say not always roads. The lake’s water levels, too, needed to be below 4,195 feet for us to see it, and those levels were partly dependent on snowfall (this winter there was lots) and how much of that snow, by the time we arrived, had melted and sluiced down the mountains — water that also, en route to the lake, could turn the 16 miles of unpaved roads into impassable mush.
More here.
INEQUALITY AND THE 2016 ELECTION OUTCOME: A DIRTY SECRET AND A DILEMMA
James Galbraith in New Geography:
Using our measure of pay inequality, which avoids any distortion associated with making a conversion to income inequality measures, the fourteen states with the largest increases in inequality after 1990 without exception voted for Hillary Clinton.1 These fourteen included almost all of the large states that Clinton carried, including California, New York, New Jersey, Massachusetts, Virginia and Illinois. The largest Clinton state below the top fourteen is Washington, and after that, Minnesota (which she carried by whisker); the others include Vermont and Delaware, small states embedded in regions (New England, the Mid-Atlantic) where the increase of inequality was much larger than it was in the states themselves. Vermont is not immune from economic change in New York or Massachusetts, nor is Delaware unaffected by events in New Jersey or Maryland.
Conversely, the seven states with the smallest increase in inequality, and ten of the lowest twelve, all voted for Donald Trump. These included Wyoming, West Virginia, Oklahoma, Utah, North Dakota, Montana, Alaska, Indiana, Nebraska and Kentucky, as well as the critical Obama-to-Trump states of Ohio and Michigan. In the middle range, we find a series of states that were (or, in the case of Georgia, might have been) competitive including Wisconsin and Pennsylvania, Florida, and North Carolina.
The correspondence of inequality-change to the election outcome is almost uncanny.
A plausible explanation emerges with a moment's thought. Clinton-majority states are characterized by high-income enclaves of finance, technology, insurance and government contracts, which often exist alongside large low-income minority and immigrant communities, sufficiently separated by geography and political boundary lines to be almost autonomous from each other. Both of these communities vote Democratic, yet out of highly differing political and social interests; the former perhaps most of all for reasons of social liberalism and environmentalism; the latter out of economic interest and historical alliances on civil rights and immigration. Where they together predominate, Democrats prevail.
More here.