From Nature:
As researchers continue to dig into the biological roots of ageing, new strategies to hold back some of its adverse effects are emerging. Several age-related conditions, including cancer, can be linked to ‘inflammageing’ — chronic, low-grade inflammation in ageing cells. Putting the brakes on inflammageing could potentially keep people healthier in old age, but learning how to control this process requires an understanding of its molecular pathways.
Researchers at The University of Texas MD Anderson Cancer Center have discovered that triple-stranded nucleic acid structures called R-loops play an important role in age-related inflammation1. These structures are typically formed during transcription, but they are usually temporary and remain in the nucleus. However, Rugang Zhang, a professor of experimental therapeutics, showed that in ageing cells these structures are exported from the nucleus to the cytoplasm.
More here.
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