Genetic Variation Impacts Drug Efficacy. Could Testing Help?

Jyoti Madhusoodanan in Undark Magazine:

In April 2019, Chloe Meadows was diagnosed with ADHD and began working with her doctor to find a drug cocktail to relieve her symptoms. Among the medicines she took was Wellbutrin, in late 2020. She recalls that about a month into taking it, however, she sat down to eat pizza, suffered a seizure, and fell, dislocating her shoulder. Family members later told her she hit her head so hard that her earring flew out. She was unconscious, she told Undark, and only woke up during the subsequent ambulance ride to the emergency room.

Afterward, she stopped taking Wellbutrin and later added a different drug to her regime, a generic version of the ADHD drug Concerta, but she said that she soon began to experience thoughts of self-harm every night: “I just mentally referred to it as Hell Hour.”

One day, Meadows missed a dose, and Hell Hour didn’t happen. Wondering if there was a connection between her prescription and the awful evenings, she changed to a generic version of Adderall.

More here.

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