Julian Nowogrodzki in Nature:
An age ‘clock’ based on some 200 proteins found in the blood can predict a person’s risk of developing 18 chronic illnesses, including heart disease, cancer, diabetes and Alzheimer’s disease. The clock’s accuracy raises the prospect of developing a single test that could describe a person’s risk of many chronic conditions, says the project’s lead scientist Austin Argentieri, a population-health researcher at Massachusetts General Hospital in Boston. “Ultimately, wanting to live longer will come down to preventing chronic diseases,” he says. The study was published in Nature Medicine on 8 August1.
Well-aged
A person’s chronological age is key to determining their risk of many age-related conditions. But chronological age is not a perfect predictor of disease. Some 60-year-olds, for example, are frail and have heart disease, whereas others are the picture of health. Argentieri and his colleagues sought to build a ‘clock’ that would accurately reflect a person’s disease status. To do so, they used data from 45,441 people, selected at random, in the UK Biobank, a repository of biomedical samples. That sample size is roughly 30 times larger than that used in a previous protein-clock study2, making it statistically more powerful.
More here.
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