A massive 8-year effort finds that much cancer research can’t be replicated

Tara Haelle in Science News:

Researchers with the Reproducibility Project: Cancer Biology aimed to replicate 193 experiments from 53 top cancer papers published from 2010 to 2012. But only a quarter of those experiments were able to be reproduced, the team reports in two papers published December 7 in eLife.

The researchers couldn’t complete the majority of experiments because the team couldn’t gather enough information from the original papers or their authors about methods used, or obtain the necessary materials needed to attempt replication.

What’s more, of the 50 experiments from 23 papers that were reproduced, effect sizes were, on average, 85 percent lower than those reported in the original experiments.

More here.