Jenny Offill’s ‘Weather’ Is Emotional, Planetary and Very Turbulent

Leslie Jamison at the NY Times:

Offill’s writing is shrewd on the question of whether intense psychic suffering heightens your awareness of the pain of others, or makes you blind to it. The answer, of course, is that it can do both; that it inevitably does both. Sometimes Offill’s narrators seem vulnerable to the delusion that their dysfunction sets them apart — that they are breaking down against the backdrop of others’ composure, which can come across as self-deprecation but is actually its own form of egotism. But part of the brilliance of Offill’s fiction is how it pushes back against this self-deception: “Stay, just stay,” the wife in “Dept. of Speculation” tells her suicidal student, a girl overcome by pain of her own; while Lizzie’s meditation teacher, who believes in reincarnation, insists that “everyone here has done everything to everyone else.” Lizzie is often overwhelmed by her interior landscape, but she is also often aware that everyone around her inhabits an interior landscape that feels just as intense; and that they are all inhabiting an exterior landscape with intensities of its own.

more here.

The Aesthetics of Architecture In A Ruined World

Kate Wagner at The Baffler:

What makes industrial landscapes unique is that they fascinate regardless of whether they’re operating. The hellish Moloch of a petrochemical refinery is as captivating as one of the many abandoned factories one passes by train, and vice versa. That doesn’t mean, though, that all industrial landscapes are created equal. Urban manufacturing factories are considered beautiful—tastefully articulated on the outside, their large windows flooding their vast internal volumes with light; they are frequently rehabilitated into spaces for living and retail or otherwise colonized by local universities. The dilapidated factory, crumbling and overgrown by vegetation, now inhabits that strange space between natural and man-made, historical and contemporary, lovely and sad. The power plant, mine, or refinery invokes strong feelings of awe and fear. And then there are some, such as the Superfund site—remediated or not—whose parklike appearance and sinister ambience remains aesthetically elusive.

more here.

The Novels of Marie NDiaye

Madeleine Schwarz at the NYRB:

Marie NDiaye, New York City, 2009

Marie NDiaye is so intelligent, so composed, so good, that any description of her work feels like an understatement. “Stop reading this review, just read her books!” you want to say. For several weeks now I’ve been carrying around NDiaye’s novels, telling friends to pick up her work. “She’s the smartest writer working today!” I say. Or else: “She’s going to win the Nobel Prize!”

Reading her books, you see a voracious, condensed history of much of twentieth-century literature. Here is an “I” reminiscent of what is often called autofiction, cool and probing; here is an interest in every tick of a woman’s mind that recalls the miniatures of French writers like Marguerite Duras. Here, where the women turn into dogs, where the birds may have a human spirit, is what seems like magical realism, though the line between what is happening and what is imagined is never quite clear.

more here.

The future of cancer genomics lies in the clinic

Editorial in Nature:

This week, Nature is publishing a suite of papers that sheds new light on the genetic causes of cancer. The results show how far our understanding of cancer has come — and how far we still have to go. The Pan-Cancer Analysis of Whole Genomes Consortium brought together researchers with nearly 750 affiliations across 4 continents. Between them, they sequenced full genomes from more than 2,600 samples representing 38 different types of cancer. The work is summarized in a News & Views article in this issue. The project is remarkable in both scope and complexity, and, partly because of this, faced challenges at every step; from acquiring samples to protecting patient privacy while putting terabytes of data into the hands of researchers.

Thanks to these efforts — and previous full-genome sequences — scientists now have an unprecedented view of the genetic changes that can contribute to cancer, and a clearer idea of where gaps in knowledge remain. Altogether, the team pinpointed 705 mutations that occurred repeatedly in the cancer genomes, suggesting that they are important for tumour growth. Of these, about 100 fell outside the protein-coding regions of the genome, but more such mutations might be uncovered with improvements in computational techniques for analysing non-coding regions. Overall, the authors found that cancer genomes contain an average of four to five mutations that drive tumour growth. In 5% of cases, however, they found no such mutations. Cancer genomes have been sequenced for more than a decade, but now researchers and the funders who support them must tackle the next challenge. The goal has always been to improve the lives of those affected by cancer, and the reams of data amassed by sequencing projects have helped. They are used by researchers to find new drug targets, and to generate new markers that can be used to match patients with the treatment most likely to help.

But most of the data so far have been limited in one crucial respect: clinical details of the sample donors are often missing.

More here.

Letter from a region in my mind

James Baldwin in The New Yorker:

I was icily determined—more determined, really, than I then knew—never to make my peace with the ghetto but to die and go to Hell before I would let any white man spit on me, before I would accept my “place” in this republic. I did not intend to allow the white people of this country to tell me who I was, and limit me that way, and polish me off that way. And yet, of course, at the same time, I was being spat on and defined and described and limited, and could have been polished off with no effort whatever. Every Negro boy—in my situation during those years, at least—who reaches this point realizes, at once, profoundly, because he wants to live, that he stands in great peril and must find, with speed, a “thing,” a gimmick, to lift him out, to start him on his way. And it does not matter what the gimmick is.

…Life is tragic simply because the earth turns and the sun inexorably rises and sets, and one day, for each of us, the sun will go down for the last, last time. Perhaps the whole root of our trouble, the human trouble, is that we will sacrifice all the beauty of our lives, will imprison ourselves in totems, taboos, crosses, blood sacrifices, steeples, mosques, races, armies, flags, nations, in order to deny the fact of death, which is the only fact we have. It seems to me that one ought to rejoice in the fact of death—ought to decide, indeed, to earn one’s death by confronting with passion the conundrum of life. One is responsible to life: It is the small beacon in that terrifying darkness from which we come and to which we shall return. One must negotiate this passage as nobly as possible, for the sake of those who are coming after us.

More here. (Note: Throughout February, at least one post will honor The Black History Month. This year’s theme is “African Americans and the Vote.” Readers are encouraged to send in their suggestions)

Saturday Poem

Rhetorical Figures

When a sentence is composed of two independent
clauses, the second being weaker than the first,
it is called One-Legged Man Standing. If it
purposefully obscures meaning, it’s called Ring
Dropped in Muddy Creek,
or if elegantly composed,
Wasp Fucking Orchid. There are words behind words,
and half the time our thoughts spraying out like water
from a hose, half the time banging inside our heads
like a wren in a house. When a sentence ends
unexpectedly because someone has punched
the speaker in the face, it’s Avalanche Sudden.
When instead the speaker is stopped with sloppy
kisses, it’s Dripping Cloud. Not to be confused
with Dripping Cone, when someone overturns
the table, or Bird Pecking the Mountain, when
the sentence goes on for an hour and a half and ends
in a shaking death. If the speaker lies in the driveway
so drunk on cheap wine that one listening cannot
get close to the meaning and thus runs away again,
claiming, “For the last time,” it’s Pregnant Dog
Cooked in Sun
. If the speaker sells everything for
an old convertible and drives out into the desert
with unintelligible shouting to the pissed-off stars:
Aching Stones Laughing. Forced incongruent words
are Fishes on Fire, and are beautiful but bring us
no closer to the Truth or the Cosmos or the All,
so either we tour Europe looking for the bodies
of saints or drink all night playing Johnny Cash LPs.
Everything we have said, we have said all our lives.
Same for what we haven’t said. Learning the terms
doesn’t help, we’re still filled over the rim with longing.
Already in the poem there is Clamshell Moon, Barn
House Burning, Cow Lowing the Field, One Hundred
Village Bells, Moth Flurry
. Somewhere above, a Torn
Shirt,
a Peasant Girl Crying, a Baby Dropped Through
Smoke to Voices Shouting.
Not much further a Cat
in Heat
, a Wailing Street, and in the end Tree Frogs
Blazing Reeds with Sound.

by Tom Christopher
from
Haydens Ferry Review

Ursula Lindsey on the Palestinian poet Mahmoud Darwish

Ursula Lindsey in the New York Review of Books:

The late Palestinian poet Mahmoud Darwish (1941–2008) liked to write in the mornings, preferably in a narrow room with a window overlooking a tree. He required solitude and coffee; he wrote in black ink on loose, thick, white paper. He often listened to music. His poems, he told the journalist and fellow poet Abbas Beydoun in 1995, always started out as a cadence, a tempo. “My mornings are sad,” Darwish said. But his afternoons and evenings could be joyful, for as he explained to Beydoun:

It happens sometimes that one writes something and then says, “Oh God” out of ecstasy. As if someone else has written it…. Sometimes, ravished by the musicality of a strophe that I have just written, I find myself going and coming in the apartment, reciting with gaiety, satisfied with myself, and telling myself, “Bravo! Bravo!” These days, after these moments of intense happiness, I reward myself with a dinner in a good restaurant, I invite friends, and I do a small feast.

Darwish made this delightful confession in one of five interviews that have been translated into English for the first time by Amira El-Zein and Carolyn Forché and collected in Palestine as Metaphor. They all took place in the mid-1990s, by which time he had been famous for three decades as the iconic voice of the Palestinian cause.

More here.

By exploiting randomness, three mathematicians have proved an elegant law that underlies the chaotic motion of turbulent systems

Kevin Hartnett in Quanta:

Picture a calm river. Now picture a torrent of white water. What is the difference between the two? To mathematicians and physicists it’s this: The smooth river flows in one direction, while the torrent flows in many different directions at once.

Physical systems with this kind of haphazard motion are called turbulent. The fact that their motion unfolds in so many different ways at once makes them difficult to study mathematically. Generations of mathematicians will likely come and go before researchers are able to describe a roaring river in exact mathematical statements.

But a new proof finds that while certain turbulent systems appear unruly, they actually conform to a simple universal law. The work is one of the most rigorous descriptions of turbulence ever to emerge from mathematics. And it arises from a novel set of methods that are themselves changing how researchers study this heretofore untamable phenomenon.

More here.

An Unsettling New Theory: There Is No Swing Voter

David Freedlander in Politico:

What if everything you think you know about politics is wrong? What if there aren’t really American swing voters—or not enough, anyway, to pick the next president? What if it doesn’t matter much who the Democratic nominee is? What if there is no such thing as “the center,” and the party in power can govern however it wants for two years, because the results of that first midterm are going to be bad regardless? What if the Democrats’ big 41-seat midterm victory in 2018 didn’t happen because candidates focused on health care and kitchen-table issues, but simply because they were running against the party in the White House? What if the outcome in 2020 is pretty much foreordained, too?

To the political scientist Rachel Bitecofer, all of that is almost certainly true, and that has made her one of the most intriguing new figures in political forecasting this year.

Bitecofer, a 42-year-old professor at Christopher Newport University in the Hampton Roads area of Virginia, was little known in the extremely online, extremely male-dominated world of political forecasting until November 2018. That’s when she nailed almost to the number the nature and size of the Democrats’ win in the House, even as other forecasters went wobbly in the race’s final days. Not only that, but she put out her forecast back in July, and then stuck by it while polling shifted throughout the summer and fall.

And today her model tells her the Democrats are a near lock for the presidency in 2020, and are likely to gain House seats and have a decent shot at retaking the Senate.

More here.

Zilia Sánchez’s Island of Erotic Forms

Jillian Steinhauer at the NY Times:

The Cuban-born Ms. Sánchez, who will turn 94 this summer, has spent some 50 years making abstract, shaped, sculptural paintings, and is still at work. While modern art has a firmly established tradition of objects that simultaneously hang on the wall and jut into space (think of Robert Rauschenberg’s collagelike “Combines”) and of monochrome, geometric canvases (see Carmen Herrera and Ellsworth Kelly) Ms. Sánchez does something different.

She isn’t self-conscious about operating between mediums, and her work doesn’t ask clever formal questions. Instead, its curves and mounds, swells and protrusions allude to recognizable sources, most notably the landscape, the moon, and the female body.

more here.

Pushing Through a Public Memorial

Natasha Becker at The Brooklyn Rail:

Aesthetically the artworks are strangely, hauntingly beautiful. They spark a desire to sojourn a while with the images, sensing that each one offers something that is difficult to refuse, difficult to ignore. In this regard, the collection of works compel the viewer to experience their testimony. Without this aesthetic intervention, the paintings might lack force and simply read as interesting comments on a political moment. Instead, it is an evocation of a sense of vulnerability and beauty that is the enlivening force in this body of work.

The viewer becomes caught in a painting’s gaze—a gaze that works emotionally, psychologically, affectively. The paintings go beyond simply representing some aspect of a past event.

more here.

When We Fought A Lot of Dwarves

Benjamin Markovits at the TLS:

And yet there were probably also ways in which the characters we created revealed something about us. I liked outsiders of various kinds, half-orcs and thieves, sympathetic fringe types; partly, no doubt, because I never stayed anywhere long enough in my childhood to be an insider. For some reason, I also preferred shorter races, halflings and dwarves, and identified with the Bilbos and Gimlis of the world rather than the Aragorns and Boromirs – the tall, powerful men – although I was six foot six (and a deeply frustrated benchwarmer on the basketball team) by the time I finished high school. D&D grew out of Middle Earth and drew on William Morris-style fantasies of medievalism. I read Morris, too (The Defence of Guenevere), and like any good American loved the Cotswolds (which we day-tripped into during our Oxford years). The charm of the English countryside suggests a life in which you can walk out of one small world, through fields, hills and countryside, to enter another, and this is also the romance of Dungeons & Dragons.

more here.

Voting Rights Act of 1965

From History.com:

The Voting Rights Act of 1965, signed into law by President Lyndon B. Johnson, aimed to overcome legal barriers at the state and local levels that prevented African Americans from exercising their right to vote as guaranteed under the 15th Amendment to the U.S. Constitution. The Voting Rights Act is considered one of the most far-reaching pieces of civil rights legislation in U.S. history.

Lyndon B. Johnson assumed the presidency in November 1963 upon the assassination of President John F. Kennedy. In the presidential race of 1964, Johnson was officially elected in a landslide victory and used this mandate to push for legislation he believed would improve the American way of life, such as stronger voting-rights laws. After the Civil War, the 15th Amendment, ratified in 1870, prohibited states from denying a male citizen the right to vote based on “race, color or previous condition of servitude.” Nevertheless, in the ensuing decades, various discriminatory practices were used to prevent African Americans, particularly those in the South, from exercising their right to vote. During the civil rights movement of the 1950s and 1960s, voting rights activists in the South were subjected to various forms of mistreatment and violence. One event that outraged many Americans occurred on March 7, 1965, when peaceful participants in a Selma to Montgomery march for voting rights were met by Alabama state troopers who attacked them with nightsticks, tear gas and whips after they refused to turn back.

More here. (Note: Throughout February, at least one post will honor The Black History Month. This year’s theme is “African Americans and the Vote.” Readers are encouraged to send in their suggestions)

Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice

Catherine Offord in The Scientist:

Researchers at the University of Washington have discovered a novel DNA-sensing pathway that launches an antiviral response to foreign genetic material in human cellsTriggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses to DNA—and is missing or inactive in mouse cells. The finding raises questions about the promise of therapies that target cGAS-STING for immune modulation, researchers report today (January 24) in Science Immunology. “This seems to be a DNA-sensing pathway that’s been completely overlooked—probably because much of the research that has been done has used murine systems,” says Christian Holm, who researches cGAS-STING at Aarhus University and was not involved in the study. Previous work on antiviral responses has focused almost exclusively on cGAS-STING, he adds. “Now this comes along and says there’s this other pathway . . . that seems to be completely independent of STING and might be very important.”

First described in 2013, the cGAS-STING pathway plays a critical role in the cell’s innate immune reaction to viral infection. Upon detecting cytosolic DNA (usually a tell-tale sign of viral entry), the cGAS enzyme binds to the transmembrane protein STING to trigger the production of interferons and other antiviral responses.

More here.

Taxing the Superrich

Gabriel Zucman and Emmanuel Saez in the Boston Review:

Wealth is power. An extreme concentration of wealth means an extreme concentration of power: the power to influence government policy, the power to stifle competition, the power to shape ideology. Together, these amount to the power to tilt the distribution of income to one’s advantage. This is the core reason why the extreme wealth of some can reduce what remains for the rest—why part of the income of today’s superrich can be earned at the expense of the rest of society. That’s what earned John Astor, Andrew Carnegie, John Rockefeller, and other Gilded Age industrialists their epithet of “Robber Barons.”

In much of the twentieth century, the U.S. tax system protected against such extreme disparities. But far from curbing this trend, the tax system in the last four decades has instead reinforced it. The three traditional progressive taxes—the individual income tax, the corporate income tax, and the estate tax—have all weakened. The top marginal federal income tax rate has fallen dramatically, from more than 70 percent every year between 1936 and 1980—in fact, often higher, peaking at 94 percent during the final years of World War II—to 37 percent in 2018.

More here.

Immune cell which kills most cancers discovered by accident by British scientists in major breakthrough

Sarah Knapton at MSN:

Researchers at Cardiff University were analysing blood from a bank in Wales, looking for immune cells that could fight bacteria, when they found an entirely new type of T-cell.

That new immune cell carries a never-before-seen receptor which acts like a grappling hook, latching on to most human cancers, while ignoring healthy cells.

In laboratory studies, immune cells equipped with the new receptor were shown to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer.

Professor Andrew Sewell, lead author on the study and an expert in T-cells from Cardiff University’s School of Medicine, said it was “highly unusual” to find a cell that had broad cancer-fighting therapies, and raised the prospect of a universal therapy.

More here.

Would you stand up to an oppressive regime or would you conform? Here’s the science

Nick Chater in The Conversation:

There are countless examples of past and present monstrous regimes in the real world. And they all raise the question of why people didn’t just rise up against their rulers. Some of us are quick to judge those who conform to such regimes as evil psychopaths – or at least morally inferior to ourselves.

But what are the chances that you would be a heroic rebel in such a scenario, refusing to be complicit in maintaining or even enforcing the system?

To answer this question, let’s start by considering a now classic analysis by American organisational theorist James March and Norwegian political scientist Johan Olsen from 2004.

They argued that human behaviour is governed by two complementary, and very different, “logics”. According to the logic of consequence, we choose our actions like a good economist: weighing up the costs and benefits of the alternative options in the light of our personal objectives. This is basically how we get what we want.

But there is also a second logic, the logic of appropriateness.

More here.

The Bard of Capitalist Realism

Ed Simon at Poetry Magazine:

As is apparent, Bonney’s work is not purely aesthetic or for its own sake; it’s not romantic or confessional in the sense of the personal divorced from the political, if such a thing is even possible. That’s not to suggest that his work is simple or accessible. In keeping with the British Poetry Revival of the 1960s and 1970s, in which poets rejected the prevailing conservatism of British literature, Bonney’s work is difficult, transgressive, subversive, and at times hermetic. “Don’t get me wrong,” Bonney writes in “Letter Against the Language,” “I’m not about to disappear into some kind of curate Cloud of Unknowing, or worse, some comfortably opaque experimental poetry. I mean, fuck that shit.” Our Death bears the imprints of such avant-garde movements as sound poetry, concrete poetry, visual poetry, and performance art. As a working-class boy from Brighton, Bonney was steadfastly leftist in his verse, though, as he noted in a recent interview with Jeffrey Grunthaner in BOMB, “I hate mainstream left wing artists. I don’t consider my work to be protest work. I’m not trying to convince anybody to not like capitalism. My ideal audience already hates cops.” Some of the best prophets aren’t there to make you do stuff; they exist to bear witness.

more here.