Charles Graeber in Wired:
JAMES ALLISON LOOKS like a cross between Jerry Garcia and Ben Franklin, and he’s a bit of both, an iconoclastic scientist and musician known for good times and great achievements. He also doesn’t always answer his phone, especially when the call arrives at 5 am, from an unfamiliar number.
So when the Nobel Prize committee tried to reach Allison a few weeks ago to inform him he’d been awarded the 2018 Nobel Prize in medicine, Allison ignored the call. Finally, at 5:30 am, Allison’s son dialed in on a familiar number to deliver the news. The calls have not stopped since.
Allison’s breakthrough was the discovery of a sort of secret handshake that cancer uses to evade the immune system, and a means to block that handshake—what the Nobel committee hailed as “a landmark in our fight against cancer,” which has “revolutionized cancer treatment, fundamentally changing the way we view how cancer can be managed.” (Allison’s co-recipient was Tasuku Honjo of Kyoto University.) Advances in cancer typically come in 50-year increments; the science that Allison and Honjo helped advance, cancer immunotherapy, has made a generational leap seemingly overnight.