What to expect in 2014: Nature takes a look at what is in store for science in the new year.

Richard Van Noorden in Nature:

CometSpace probes: The European Space Agency’s Rosetta spacecraft could become the first mission to land a probe on a comet. If all goes well, it will land on comet Churyumov–Gerasimenko in November. Mars will also be a busy place: India’s orbiter mission should arrive at the planet in September, about the same time as NASA’s MAVEN probe. And NASA’s Curiosity rover should finally make it to its mission goal, the slopes of the 5.5-kilometre-high Aeolis Mons, where it will look for evidence of water. Back on Earth, NASA hopes to launch an orbiter to monitor atmospheric carbon dioxide.

Neural feats: Neurobiologist Miguel Nicolelis at Duke University in Durham, North Carolina, has developed a brain-controlled exoskeleton that he expects will enable a person with a spinal-cord injury to kick the first ball at the 2014 football World Cup in Brazil. Meanwhile, attempts are being made in people with paralysis to reconnect their brains directly to paralysed areas, rather than to robotic arms or exoskeletons. In basic research, neuroscientists are excited about money from big US and European brain initiatives, such as Europe’s Human Brain Project.

Novel drugs: In the pharmaceutical industry, all eyes are on trial results from two competing antibody treatments that harness patients’ immune systems to fight cancer. The drugs, nivolumab and lambrolizumab, work by blocking proteins that prevent a person’s T cells from attacking tumours. In early tests, the drugs evoked a better level of response in patients than ipilimumab, a similar therapy that was launched in 2011 to treat advanced melanoma.

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