Scientists place 500-million-year-old gene in modern organism

From PhysOrg:

BacIt's a project 500 million years in the making. Only this time, instead of playing on a movie screen in Jurassic Park, it's happening in a lab at the Georgia Institute of Technology. Using a process called paleo-experimental evolution, Georgia Tech researchers have resurrected a 500-million-year-old gene from bacteria and inserted it into modern-day Escherichia coli(E. coli) bacteria. This has now been growing for more than 1,000 , giving the scientists a front row seat to observe evolution in action. “This is as close as we can get to rewinding and replaying the molecular tape of life,” said scientist Betül Kaçar, a NASA astrobiology postdoctoral fellow in Georgia Tech's NASA Center for Ribosomal Origins and Evolution. “The ability to observe an ancient gene in a modern organism as it evolves within a modern cell allows us to see whether the evolutionary trajectory once taken will repeat itself or whether a life will adapt following a different path.”

In 2008, Kaçar's postdoctoral advisor, Associate Professor of Biology Eric Gaucher, successfully determined the ancient genetic sequence of Elongation Factor-Tu (EF-Tu), an essential protein in E. coli. EFs are one of the most abundant proteins in bacteria, found in all known cellular life and required for bacteria to survive. That vital role made it a perfect protein for the scientists to answer questions about evolution.After achieving the difficult task of placing the ancient gene in the correct chromosomal order and position in place of the modern gene within E. coli, Kaçar produced eight identical bacterial strains and allowed “ancient life” to re-evolve. This chimeric bacteria composed of both modern and ancient genes survived, but grew about two times slower than its counterpart composed of only modern genes.

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Stopping Crime Before It Starts

MinorityreportRisk terrain modeling maps various risk factors to identify areas where crimes are more likely to occur. For example, Rutgers University computational criminologist Joel Caplan mapped for Irvington, New Jersey four crime risk factors correlated with shooting incidents. The risk factors were the locations of gang member residences, public bus stops, schools, and facilities like bars, clubs, fast food restaurants, and liquor stores. He found that “the likelihood of a shooting happening at particular 100-foot-by-100-foot places in Irvington during 2007 increases by 143 percent as each additional risk factor affects that place.”

In June, Brantingham and his colleagues published a study that applied Lotka-Volterra equations used by biologists for decades to determine the hunting ranges of animals in the wild to map the territories of street gangs. Their model predicted that 59 percent of gang crimes would occur within two blocks of a border between two gangs and 87.5 percent would occur within about three blocks. When the researchers mapped more than 500 crimes attributed to 13 gangs in a specific area of Los Angeles, they found in fact that 58 percent and 83 percent occurred within two blocks and three blocks of a border respectively. “You would think that we're more complicated than other animals, so a model this simplistic shouldn't work, but I was surprised that it fit as well as it did,” said study co-author Martin Short, an assistant adjunct professor of mathematics at UCLA in Wired UK.

More from Reason.com here.

Which Diet Works?

Mark Bittman in the New York Times:

Diet-cokeOne of the challenges of arguing that hyperprocessed carbohydrates are largely responsible for the obesity pandemic (“epidemic” is no longer a strong enough word, say many experts) is the notion that “a calorie is a calorie.”

Accept that, and you buy into the contention that consuming 100 calories’ worth of sugar water (like Coke or Gatorade), white bread or French fries is the same as eating 100 calories of broccoli or beans. And Big Food — which has little interest in selling broccoli or beans — would have you believe that if you expend enough energy to work off those 100 calories, it simply doesn’t matter.

There’s an increasing body of evidence, however, that calories from highly processed carbohydrates like white flour (and of course sugar) provide calories that the body treats differently, spiking both blood sugar and insulin and causing us to retain fat instead of burning it off.

In other words, all calories are not alike.

More here.

Stories of faith and devotion

Nadeem F. Paracha in Dawn:

ScreenHunter_04 Jul. 12 10.12I have never been a very religious person. But I’ve always been a firm believer. And ironically, over the decades as the intellectual credence and credibility of secularism has continued to grow in my eyes (now more than ever), so has my fascination with religion, especially with the way it is indulged in by my fellow countrymen and women, or for that matter, by me.

I was a child of the 1970s, an era in the sociology of Pakistan that began to seem rather alien when I entered my teens in the 1980s.

One of the major triggers in this respect was, of course, the mushrooming of exhibitionistic religiosity, preliminarily initiated by the state, and then eventually undertaken by large sections of the society as a whole.

I see this process as a kind of self-hypnosis, partaken to not only project religious exhibitionism as some sort of a reflection to define (or redefine) one’s identity as a Pakistani or Muslim, but also (on a more cynical level), understand it as something that attracts economic and political benefits.

More here.

Another Stab At The U.S. Constitution

Ten legal scholars propose their own changes to the 225 year-old US Constitution, via NYTimes:

ConstitutionA recent study said that the U.S. Constitution was declining in influence. According to the authors, “the constitutions of the world’s democracies are, on average, less similar to the U.S. Constitution now than they were at the end of World War II.”

As the United States prepares to mark the 225th anniversary of its Constitution, we have the benefit of hindsight that the framers lacked. What should be omitted, clarified or added?

“Sometimes prison sentences — even the most severe — are a rational response to crime. But often, sentences are the product of a political process in which politicians are scared of appearing soft on crime so they do not even question the reasonableness of a proposed criminal law. It is the norm, not the exception, for politicians to reflexively push for harsher sentences without considering empirical evidence about what level of sanction is necessary for deterrence or what impact a sentence will have on communities. It is an environment long on rhetoric and short on reflection.

The Constitution has failed to check this pathological process. The Eighth Amendment bans “cruel and unusual punishments.” But some justices do not think this bans excessive prison terms. And the requirement that a sentence be “unusual” has meant that the justices often do little more than count up states with similar sentences without looking at how states reached those outcomes.”

For the whole debate, click here.

Mad, bad, sad: What really happens to US soldiers

By Nan Levinson, via Al Jazeera:

Mad, bad, sadFormer army staff sergeant Andy Sapp spent a year at Forward Operating Base Speicher near Tikrit, Iraq, and has lived for the past six years with PTSD. Seven, if you count the year he refused to admit that he had it, never leaving the base or firing his weapon – and who was he to suffer, when others had it so much worse? Nearly 50 when he deployed, he was much older than most of his National Guard unit. He had put in 17 years in various branches of the military, had a stable family, strong religious ties, a good education, and a satisfying career as a high-school English teacher. He expected all that to insulate him, so it took a while to realise that the whole time he was in Iraq, he was numb. In the end, his PTSD would be be diagnosed he would be given an 80 per cent disability rating, which, among other benefits, entitles him to sessions with a Veterans Administration psychologist, whom he credits with saving his life.

Andy recalls a 1985 BBC series named “Soldiers”, in which a Marine commander says: “It's not that we can't take a man who is 45 years old and turn him into a good soldier. It's that we can't make him love it.” Like many soldiers, Andy had assumed that his role would be to protect his country when it was threatened. Instead, he now considers himself part of “something evil.” So at a point when his therapy stalled and his therapist suggested that his spiritual pain was exacerbating his psychological pain, it suddenly clicked. The spiritual part he now calls his sacred wound. Others call it “moral injury”.

It's a concept in progress, defined as the result of taking part in or witnessing something of consequence that you find wrong, something which violates your deeply held beliefs about yourself and your role in the world. For a moment, at least, you become what you never wanted to be. While the symptoms and causes may overlap with PTSD, moral injury arises from what you did or failed to do, rather than from what was done to you. It's a sickness of the heart more than the head. Or, possibly, moral injury is what comes first and, if left unattended, can congeal into PTSD.

Read the rest here.

healing spirits

Faithhealer

Jose Pedro de Freitas, known by his nickname Zé Arigó was born in 1921 or 1922 at a farm site six kilometers outside the town of Congonhas do Campo, in the mountainous state of Minas Gerais. As a young man, he was different, tormented by headaches and a strange white light, and then, as he grew older, dreams. In these, he found himself in an unfamiliar chamber, watching gowned and aproned figures speaking a foreign tongue. One night, a severe, stout, bald man, frock buttoned to his chin—a monster, Arigó would later say separated himself from the others, identified himself as Dr. Adolph Fritz, a German killed in World War I, and announced that he’d selected Arigó to carry out his earthly work. That night of revelation, Arigó awoke screaming. He sought help from doctors and the local priest—to no avail. It was only when he obeyed the surgeon that the nightmares ceased. Speaking German (a language he had never learned) and operating without anesthesia or antisepsis, Arigó used any tool at hand—butcher knives, scissors, rusty garden shears. He removed tumors and kidney stones, scarcely shedding blood. He cured blindness by sliding a blade high behind the orbit. Other times, like Jesus and the paralytic at Capernaum, Arigó simply commanded an illness to desist.

more from Daniel Mason at Lapham’s Quarterly here.

The last crusade

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A complex debate has arisen about the relationship between the Enlightenment and the Christian tradition. As the notion of the Christian tradition and of “Western civilisation” have become fused, and as the Enlightenment has come to be seen as embodying Western values, so some have tried to co-opt the Enlightenment into the Christian tradition. The Enlightenment ideas of tolerance, equality and universalism, they argue, derive from the reworking of notions already established within the Christian tradition. Others, more ambiguous about the legacy of the Enlightenment, argue that true liberal, democratic values are Christian and that the radicalism and secularism of the Enlightenment has only helped undermine such values. Both views are wrong. For a start, the historic origins of many of these ideas lie, as we have seen, outside the Christian tradition. It is as apt to describe concepts such as equality or universalism as Greek as it is to describe them as Christian. In truth, though, the modern ideas of equality or universality are neither Greek nor Christian. Whatever their historical origins, they have become peculiarly modern concepts, the product of the specific social, political and intellectual currents of the modern world.

more from Kenan Malik at Eurozine here.

unforgettably whitened with dust

Turner

And then you see it. It is an Arab dhow or an Egyptian felucca, boats characterised by an angled hypotenuse sail the shape of a thorn. The sculpture is a curved craft, adrift on the grain of the wood, with a cabin and an angled sail – that schematic lever. We call this the “secretary effect” – the unregenerate moment in Superman comics when the secretary takes off her specs (a synecdoche for all her clothes) and Superman suddenly appreciates the pulchritude that was there all the time. After this delicious shock, you take in the effect of the bronze casting – the transfiguration of an Arp-like objet trouvé into something classical, something measured. Then there is the applied partial patina of grey and grey-white paint on the darker grey of the wood – which reads like dirty salt deposits on a working vessel. The mood it enforces suggests not only shipping but an emblem of age. And we are back with the grim functionary, except that now we can make out the name on the lapel badge – Death.

more from Craig Raine at The New Statesman here.

Europe on the verge of a nervous breakdown

Richard Evans in New Statesman:

FasA spectre is haunting Europe: the spectre of unemployment. At the latest count, there were almost 25 million people in the member states of the European Union without a job, an increase of two million on the same point in the previous year. This is well over 10 per cent of the workforce, and in some countries the situation is much worse. At the top of the list is Spain, with 25 per cent unemployed, followed by Greece, with nearly 23 per cent. Particularly hard-hit are the young. In Greece and Spain more than half the workforce below the age of 25 is without a job. The youth unemployment rate across the EU is running at 22 per cent. And there are no signs of the upward trend being reversed.

At the same time, openly neo-Nazi parties are on the rise. In Greece, the Golden Dawn movement shot from nowhere to win 21 seats in the legislature at the May election and 18 in the rerun election a few weeks later, attracting nearly 7 per cent of the popular vote. The party’s flag is black, white and red, like that of the original Nazi Party in Germany, with a swastika-like emblem at the centre (Golden Dawn denies any resemblance and claims that the symbol is a “Greek meander”). Not only has it issued threats of violence against parliamentary deputies who oppose its policies but it has also been involved in numerous violent incidents across Greece. During the campaign, television viewers were treated to the spectacle of a party spokesman assaulting two female politicians during a live debate. In 2012, it campaigned on the election slogan “So we can rid this land of filth”.

More here.

Why Do We Say That Someone is “Hot”?

From Scientific American:

HotWhat do a chilly reception, a cold-blooded murder, and an icy stare have in common? Each plumbs the bulb of what could be called your social thermometer, exposing our reflexive tendency to conflate social judgments—estimations of another’s trust and intent — with the perception of temperature. Decades of fascinating cross-disciplinary studies have illuminated the surprising speed, pervasiveness and neurobiology of this unconscious mingling of the personal and the thermal.

The blurring of ‘heat’ and ‘greet’ is highlighted in a recent experiment by Ohio University’s Matthew Vess, who asked whether this tendency is influenced by an individual’s sensitivity to relational distress. They found that people high in the psychological attribute called attachment anxiety (a tendency to worry about the proximity and availability of a romantic partner) responded to memories of a relationship breakup with an increased preference for warm-temperature foods over cooler ones: soup over crackers. Subjects low in attachment anxiety — those more temperamentally secure — did not show this “comfort food” effect. In a related part of the same experiment, subjects were asked to reconstruct jumbled words into sentences that had either cold or warm evocations. (Sentence reconstruction tasks involving specific themes are known to unconsciously influence subsequent behavior.) After being temperature-primed, Vess’s subjects rated their perceptions of their current romantic relationship. As in the first condition, subjects higher in attachment anxiety rated their relationship satisfaction higher when prompted with balmier phrases than with frosty ones.

More here.

Wednesday Poem

Grammar

Maxine, back from a weekend with her boyfriend,
smiles like a big cat and says
that she's a conjugated verb.
She's been doing the direct object
with a second person pronoun named Phil,
and when she walks into the room,
everybody turns:

some kind of light is coming from her head.
Even the geraniums look curious,
and the bees, if they were here, would buzz
suspiciously around her hair, looking
for the door in her corona.
We're all attracted to the perfume
of fermenting joy,

we've all tried to start a fire,
and one day maybe it will blaze up on its own.
In the meantime, she is the one today among us
most able to bear the idea of her own beauty,
and when we see it, what we do is natural:
we take our burned hands
out of our pockets,
and clap.

by Tony Hoagland
from Donkey Gospel, 1998
Graywolf Press, St. Paul, Minn.

The 11 Ways That Consumers Are Hopeless at Math

Derek Thompson in The Atlantic:

ScreenHunter_03 Jul. 11 10.59You walk into a Starbucks and see two deals for a cup of coffee. The first deal offers 33% extra coffee. The second takes 33% off the regular price. What's the better deal?

“They're about equal!” you'd say, if you're like the students who participated in a new study published in the Journal of Marketing. And you'd be wrong. The deals appear to be equivalent, but in fact, a 33% discount is the same as a 50 percent increase in quantity. Math time: Let's say the standard coffee is $1 for 3 quarts ($0.33 per quart). The first deal gets you 4 quarts for $1 ($0.25 per quart) and the second gets you 3 quarts for 66 cents ($.22 per quart).

The upshot: Getting something extra “for free” feels better than getting the same for less. The applications of this simple fact are huge. Selling cereal? Don't talk up the discount. Talk how much bigger the box is! Selling a car? Skip the MPG conversion. Talk about all the extra miles.

There are two broad reasons why these kind of tricks work. First: Consumers don't know what the heck anything should cost, so we rely on parts of our brains that aren't strictly quantitative. Second: Although humans spend in numbered dollars, we make decisions based on clues and half-thinking that amount to innumeracy.

More here.

Think Again: India’s Rise

Sumit Ganguly in Foreign Policy:

ScreenHunter_02 Jul. 11 10.54On foreign policy, India has shown growing global aspirations — and capabilities. It is the fifth-largest player in the reconstruction of war-ravaged Afghanistan, and its reach extends well beyond its neighborhood. At the recent G-20 summit in Los Cabos, Mexico, Prime Minister Manmohan Singh pledged $20 billion to an endowment designed to shore up the IMF's lending capacity.

Unfortunately, the fascination with India's growing economic clout and foreign-policy overtures has glossed over its institutional limits, the many quirks of its political culture, and the significant economic and social challenges it faces. To cite but one example, at least 30 percent of Indian agricultural produce spoils because the country has failed to develop a viable supply chain. Foreign investors could alleviate, if not solve, that problem. But thanks to the intransigence of a small number of political parties and organized interest groups, India has refused to open its markets to outsiders. Until India can meet basic challenges like this, its greatness will remain a matter of rhetoric, not fact.

More here.

We mustn’t allow Muslims in public life to be silenced

Mehdi Hasan in The Guardian:

ScreenHunter_01 Jul. 11 10.26Have you ever been called an Islamist? How about a jihadist or a terrorist? Extremist, maybe? Welcome to my world. It's pretty depressing. Every morning, I take a deep breath and then go online to discover what new insult or smear has been thrown in my direction. Whether it's tweets, blogposts or comment threads, the abuse is as relentless as it is vicious.

You might think I'd have become used to it by now. Well, I haven't. When I started writing for a living, I never imagined I'd be the victim of such personal, such Islamophobic, attacks, on a near-daily basis. On joining the New Statesman in 2009, I was promptly subjected to an online smear campaign, involving a series of selectively edited videos of speeches I'd delivered in front of groups of Muslim university students several years ago. I was accused of being a “secret” member of the extremist group Hizb ut-Tahrir, and a “dangerous Muslim shithead” in the “same genre” as the Nazis. The post that sticks in my mind is from the blogger who referred to me as a “moderate cockroach” whose Islamic faith was “no different from the Islam of Abu Hamza, Abu Qatada, Ayman al-Zawahiri, Anjem Choudary or any of the 'tiny minority' of Islamic terrorists who believe that Islam must dominate, no matter what the cost”.

Three years later, as I leave the New Statesman to join the Huffington Post UK, little seems to have changed. “Huffington Post's new UK political director brings pro-Iran baggage,” screamed the headline on the Fox News website back in late May. My “baggage”? I once publicly praised a fatwa from Iran's supreme leader, Ayatollah Ali Khamenei, forbidding the production of nuclear weapons. Shame on me! Another ultra-conservative US news website, the Washington Free Beacon, referred to me as the “HuffPo's house jihadi”.

More here.

FATA is not a country in Africa

Slightly old, but a very insightful piece from Myra MacDonald at Reuters:

FATAU.S. Defense Secretary Leon Panetta is using increasingly forthright terms to describe the spillover of the war in Afghanistan into Pakistan’s Federally Administered Tribal Areas (FATA) in its campaign of drone strikes. “We are fighting a war in the FATA, we are fighting a war against terrorism,” he said during a visit to India. The idea that the United States is at war inside Pakistan, albeit in its tribal areas bordering Afghanistan, is not new. But the use of language is significant, requiring as Spencer Ackerman noted at Danger Room, “a war-weary (US) public to get used to fighting what’s effectively a third war in a decade, even if this one relies far more on remote controlled robots than ground troops”.

Panetta’s choice of words (and venue for delivering them) may not go down too well with Pakistani authorities in Islamabad/Rawalpindi. It is not particularly promising for the people of FATA either, who find themselves caught in the middle of a shadow war between the United States and Pakistan. But in one respect, it is not necessarily a bad thing. Rarely has the United States fought a war in a place about which it knows so little. If Panetta’s comments force people to learn about FATA, it might even lift us out of what until now has been a polemical debate between supporters and opponents of drone strikes, with little attention paid to the voices of people who actually live there.

For a start, we have to understand that not only are those voices not heard, but they are actively marginalised. For the U.S. administration, arguing that drone attacks are legal, ethical and wise, and a complicit U.S. public, the people on the ground are best dismissed as turbaned, bearded dangerous folks living in “the tribal badlands” (a phrase that really ought to be banned along with “Graveyard of Empires” and “the Great Game”.) For opponents of drones in Pakistan, their voices are marginalised by a virulent strain of anti-Americanism through which political popularity or greater bargaining power in negotiations with the United States can best be attained by whipping up rage about the drone strikes.

Read the rest here.

love hurts

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We are working under the delusion that we somehow fixed society with feminism or whatever. We’ve removed the traditional barriers to marriage based on anything other than true love. Because women can earn their own living, they no longer have to consider the economic status of their mate. We are a more racially tolerant society, and so we no longer have to restrict our choices by race. Class stratifications have disappeared from the dating scene; the words dowry and salary do not come up in negotiations. We only have to listen to our hearts to know what we want. And then we just have to find it. If that were true, if we truly had removed all societal pressures from our relationships, then why are so many miserable singles looking for love? So many women harassed by the ticking of their biological clocks, unable to find men to father their children? So many submissions every week to the Modern Love column?

more from Jessa Crispin at The Smart Set here.

the floating world

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Every element in a Japanese painting has symbolic value, chosen for its auspicious nature. Catalogue entries that describe a work merely as ‘birds and flowers’ entirely miss the point. Specific creatures have specific meanings and are associated with particular plants and seasons. Cranes go with pines, tortoises with bamboo, and all four signify long life. Screech quotes a humorous poem to the effect that the inept artist adds bamboo to an image so that the viewer will know that the animal in his picture is a tiger, not a cat. Tigers went with bamboos, cats with peonies. While the Kanō were the official painters of the shogunate, the Tosa worked for the emperor’s court in Kyoto. The court’s power had been wrested away by the shogunate centuries earlier. Its entire claim to reverence was that it perpetuated classical Japanese tradition. The Tosa painted scenes of the exquisite world of the ancient court. The snag was that the most revered classics, The Tale of Genji and The Tales of Ise, depict lives of utter decadence. Genji the Shining Prince spends his time seducing court ladies, while Narihira, the hero of The Tales of Ise, defiles the virgin priestess of Ise Shrine.

more from Lesley Downer at Literary Review here.