From The New York Times:
The other day, Paul Simon was rehearsing a favorite song: his own “Darling Lorraine,” about a love that starts hot but turns very cold. He found himself thinking about a three-note rhythmic pattern near the end, where Lorraine (spoiler alert) gets sick and dies. “The song has that triplet going on underneath that pushes it along, and at a certain point I wanted it to stop because the story suddenly turns very serious,” Mr. Simon said in an interview. “The stopping of sounds and rhythms,” he added, “it’s really important, because, you know, how can I miss you unless you’re gone? If you just keep the thing going like a loop, eventually it loses its power.”
An insight like this may seem purely subjective, far removed from anything a scientist could measure. But now some scientists are aiming to do just that, trying to understand and quantify what makes music expressive — what specific aspects make one version of, say, a Beethoven sonata convey more emotion than another. The results are contributing to a greater understanding of how the brain works and of the importance of music in human development, communication and cognition, and even as a potential therapeutic tool. Research is showing, for example, that our brains understand music not only as emotional diversion, but also as a form of motion and activity. The same areas of the brain that activate when we swing a golf club or sign our name also engage when we hear expressive moments in music. Brain regions associated with empathy are activated, too, even for listeners who are not musicians. And what really communicates emotion may not be melody or rhythm, but moments when musicians make subtle changes to the those musical patterns.
More here.