Squirrel monkeys can now see your true colors, thanks to gene therapy. Researchers have given the colorblind primates full color vision as adults by injecting their eyes with a human gene. The result raises questions about how the brain understands color, and it could eventually lead to gene-therapy treatments for colorblindness and other visual disorders in humans. In the world of squirrel monkeys, seeing colors is for girls. Whereas some females enjoy full color vision, males of the South American genus see only blues and yellows (see picture). They lack a gene that allows color-sensitive cells in the eye, called cones, to distinguish red and green from gray–the same distinction that confounds most colorblind humans.
Seeking a possible treatment for the human condition, vision scientist Jay Neitz and colleagues at the University of Washington, Seattle, assembled six adult squirrel monkeys, four colorblind males and two female controls. The researchers tested them daily for a year, using a computer program that presented the primates with colorful clumps of dots on a screen of similarly varied gray dots (see video). The results established each monkey's color vision, revealing that the female controls could see colors as a normal human would, while the male monkeys could not distinguish green and red clumps from the gray background. The team then injected the retinas of two of the colorblind monkeys with a virus that introduced the human gene for the red-detecting pigment in cone cells. The researchers were not optimistic. Unlike the malleable brains of young animals, adult brains are far more rigid and tend to have a harder time rewiring themselves. Many patients blinded in childhood, for example, remain blind when their eyes are repaired in adulthood, because their brains never developed the circuitry for processing what they see. Twenty weeks after the gene therapy, however, the monkeys began to spot red and green dots in the computer color tests, and soon after they were regularly acing the trials. “That's when we broke out the champagne,” says a still-surprised Neitz.