Sealed membrane systems are a defining feature of cellular life. They provide a barrier between the cell and its external environment and, in eukaryotes, divide the interior of the cell into functionally distinct compartments. Membrane proteins comprise around a third of gene products in most organisms and research is being revolutionised by the structural analysis of increasingly complex macromolecular systems.
A flavour of the current excitement in cell and membrane biology can be obtained in the research articles and reviews presented in this Nature web focus.
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