Peter Kramer writes in The New York Times:
Shortly after the publication of my book ”Listening to Prozac,” 12 years ago, I became immersed in depression. Not my own. I was contented enough in the slog through midlife. But mood disorder surrounded me, in my contacts with patients and readers. To my mind, my book was never really about depression. Taking the new antidepressants, some of my patients said they found themselves more confident and decisive. I used these claims as a jumping-off point for speculation: what if future medications had the potential to modify personality traits in people who had never experienced mood disorder? If doctors were given access to such drugs, how should they prescribe them? The inquiry moved from medical ethics to social criticism: what does our culture demand of us, in the way of assertiveness?
Invariably, as soon as I had finished my remarks, a hand would shoot up. A hearty, jovial man would rise and ask — always the same question — ”What if Prozac had been available in van Gogh’s time?” I understood what was intended, a joke about a pill that makes people blandly chipper. The New Yorker had run cartoons along these lines — Edgar Allan Poe, on Prozac, making nice to a raven. Below the surface humor were issues I had raised in my own writing. Might a widened use of medication deprive us of insight about our condition? But with repetition, the van Gogh question came to sound strange. Facing a man in great pain, headed for self-mutilation and death, who would withhold a potentially helpful treatment?
More here.