Karl Deisseroth at The Conversation:
Every cell has genes that tell it what to do. Different cells in the brain, just as other parts of the body, can be genetically targeted because different cells have different jobs. A cell that is a dopamine neuron has all the machinery needed to make the hormone dopamine. It uses different genes than a cell that makes the hormone serotonin, so they can be distinguished from each other.
And so the thought was maybe I could have a way of controlling just the dopamine cells or just the serotonin cells by inserting a specific gene into them. But I didn’t know what would work well, so I tried inserting different types of genes into neurons.
Some of the genes I tried were quite conventional; they were genes from mammals that I thought might affect the activity of neurons. But one was a gene from a single-celled algae – a microbe that converts light to energy. This gene coded for a light-activated protein called channelrhodopsin-2 that Peter Hegemann and Georg Nagel identified a few years earlier.
And I thought it was worth a try. It was the least likely to work, but why not try it?
More here.
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