Brutus' political activity initially included extensive journalistic reporting, organising with the Teachers' League and Congress movement, and leading the new South African Sports Association as an alternative to white sports bodies. After his banning in 1961 under the Suppression of Communism Act, he fled to Mozambique but was captured and deported to Johannesburg. There, in 1963, Brutus was shot in the back while attempting to escape police custody. Memorably, it was in front of Anglo American Corporation headquarters that he nearly died while awaiting an ambulance reserved for blacks.
While recovering, he was held in the Johannesburg Fort Prison cell which more than a half-century earlier housed Mahatma Gandhi. Brutus was transferred to Robben Island where he was jailed in the cell next to Nelson Mandela, and in 1964-65 wrote the collections Sirens Knuckles Boots and Letters to Martha, two of the richest poetic expressions of political incarceration.
Subsequently forced into exile, Brutus resumed simultaneous careers as a poet and anti-apartheid campaigner in London, and while working for the International Defense and Aid Fund, was instrumental in achieving the apartheid regime's expulsion from the 1968 Mexican Olympics and then in 1970 from the Olympic movement.
Upon moving to the US in 1971, Brutus served as a professor of literature and African studies at Northwestern (Chicago) and Pittsburgh, and defeated high-profile efforts by the Reagan Administration to deport him during the early 1980s. He wrote numerous poems, ninety of which will be published posthumously next year by Worcester State University, and he helped organize major African writers organizations with his colleagues Wole Soyinka and Chinua Achebe.