Elana Gotkine in Medical X Press:
For women with breast cancer, stressors are associated with deleterious alterations to the systemic and tumor immune environment, according to a study published online Feb. 14 in JAMA Network Open.
…More favorable immune-stimulatory changes were seen in association with greater perceived social support (e.g., increased serum interleukin-5 and activated natural killer cells in noncancerous breast tissue of Black women). Associations were seen for higher levels of perceived stress, exposure to discrimination, and neighborhood deprivation with systemic inflammation, deleterious immune cell profiles, and aggressive tumor biologic characteristics. Distinct immunologic features associated with stressors were identified in Black women, including chemotaxis with stress and immune suppression with stress at the systemic level and increased tumor-associated myeloid cells at the tissue level. An association was seen for perceived stress with elevated tumor mutational burden.
More here.
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