Now That We Can Alter Our Genetic Code, Should We?

Siddhartha Mukherjee in Tonic:

CancerA few days ago, I had just stepped off a podium at a cancer conference when a 50-year-old woman with a family history of breast cancer approached me. I had been discussing how my laboratory, among hundreds of other labs, was trying to understand how mutations in genes unleash the malignant behavior of cancer cells. She told me that she carried a mutation in the BRCA-1 gene—a mutation that she had likely inherited from her father. Diagnosed with cancer in one of her breasts when she was 30, she had undergone surgery, chemo, radiation and hormonal therapy. But that grim sequence of diagnosis and treatment, she told me, was hardly the main source of her torment. Now, she worried about the development of cancer in her remaining breast, or in her ovaries. She was considering a double mastectomy and the surgical removal of her ovaries. A woman carrying a BRCA-1 mutation has nearly a 60-70 percent chance of developing cancer in her breasts or ovaries during her lifetime, and yet it's difficult to predict when or where that cancer might occur. For such women, the future is often fundamentally changed by that knowledge, and yet it remains just as fundamentally uncertain; their lives and energies might be spent anticipating cancer and imagining survivorship—from an illness that they have not yet developed. A disturbing new word, with a distinctly Orwellian ring, has been coined to describe these women: previvors—pre-survivors.

The uncertainty and anxiety had cast such a pall over this woman's adult life that she did not want her grandchildren to suffer through this ordeal (her children had not been tested yet, but would likely be tested in the future). What if she wanted to eliminate that genetic heritage from her family? Could she ensure that her children, or her grandchildren, would never have to live with the fear of future breast cancer, or other cancers associated with the BRCA-1 gene? Rather than waiting to excise organs, could her children, or their children, choose to excise the cancer-linked gene?

More here.

Wednesday Poem

Meredith

Meredith, we apologise.
We were not ourselves
And you were so weak,
You picky-headed dreamer
Outsider from Ghana
With the dark-skin grandma

You, girl with nothing
Who always lost everything.

We apologise.

We regret that we hated the poor;
That we hated our free school meals,
Our second-hand jumpers,
that we had nothing
To show but ourselves.

We regret that we brought
You to your knees
In sight of the sandalled priest
Who watched through the
Coloured windows of the chapel
As we gave you a playground lesson:

Those who have nothing, are nothing.

Read more »

Time Is Contagious: How to control the subjective experience of time.

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Alan Burdick in Nautilus:

In a study published in 2011, Sylvie Droit-Volet, a neuropsychologist at Université Blaise Pascal, in Clermont-Ferrand, France, and three co-authors showed images of the two ballerinas to a group of volunteers. The experiment was what’s known as a bisection task. First, on a computer screen, each subject was shown a neutral image lasting either 0.4 seconds or 1.6 seconds; through repeated showings, the subjects were trained to recognize those two intervals of time, to get a feel for what each is like. Then one or the other ballerina image appeared onscreen for some duration in between those two intervals; after each viewing, the subject pressed a key to indicate whether the duration of the ballerina felt more like the short interval or the long one. The results were consistent: the ballerina en arabesque, the more dynamic of the two figures, seemed to last longer on screen than it actually did.

That makes a certain sense. Related studies have revealed a link between time perception and motion. A circle or triangle that moves quickly across your computer monitor will seem to last longer on screen than a stationary object does; the faster the shapes move, the bigger the distortion. But the Degas sculptures aren’t moving—they merely suggest movement. Typically, duration distortions arise because of the way you perceive certain physical properties of the stimulus. If you observe a light that blinks every tenth of a second and simultaneously hear a series of beeps at a slightly slower rate—every fifth of a second,1 say—the light will seem to you to blink more slowly than it does, in time with the beep. That’s a function of the way our neurons are wired; many temporal illusions are actually audiovisual illusions. But with Degas there’s no time-altering property—no motion—to be perceived. That property is entirely manufactured by, and in, the viewer—reactivated in your memory, perhaps even reenacted. That simply viewing a Degas can bend time in this way suggests a great deal about how and why our internal clocks work as they do.

One of the richest veins in temporal-perception research is on the effect of emotion on cognition, and Droit-Volet has conducted a number of compelling studies that explore the relationship. In a recent series of experiments, her subjects viewed a series of images of faces, each of which was neutral or expressed a basic emotion, such as happiness or anger. Each image lasted onscreen for anywhere from 0.4 seconds to 1.6 seconds, and the viewer was asked to say whether the image lasted for a “short” or a “long” time—that is, closer to one of the two standard durations they’d been trained beforehand to recognize. Consistently, viewers reported that happy faces seemed to last longer than neutral ones, and both angry and fearful faces seemed to last longer still. (The angry faces lasted even longer to 3-year-old children, Droit-Volet found.)

More here.

The Fall of Feminism

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Maria Bustillos on Jessa Crispin’s Why I Am Not A Feminist in the LA Review of Books:

THE ULTIMATE FAILURE of Why I Am Not a Feminist, Jessa Crispin’s fiery denunciation of modern American feminism, is all the more disappointing because the good parts are so good. Crispin’s book would be an important read in any case; in the wake of Hillary Clinton’s 2016 defeat, it is an essential one. Feminism, Crispin argues, betrayed its anti-capitalist roots in favor of “identity politics”: it failed when the focus shifted “from society to the individual.” “What was once collective action and a shared vision for how women might work and live in the world,” she writes, gave way to “a focus on individual history and achievement, and an unwillingness to share space with people with different opinions, worldviews, and histories.” Calls for women’s “empowerment” came, increasingly, at the expense of absolute demands for radical systemic change toward a fairer, more egalitarian society.

Crispin rightly calls out the rich feminists, the racist feminists, and the lazy and entitled feminists who’ve lost touch with their less advantaged sisters. Feminism “ended up doing patriarchy’s work,” she contends:

Now that we have access as women, women in positions of power are much less likely to attempt to dismantle this system of inequality. Power feels good. Capitalism feels good. It gives you things, as long as its boot is not on your neck.

In an especially strong passage, she describes the treacherous path modern American women took, and are taking, to “empowerment”:

[Y]ou will have to exhibit the characteristics of the patriarchs who built [the system]. In order to advance, you will have to mimic their behavior, take on their values […]

It’s nice in there […] If you value power, people will give you power, and with that comes money, luxury, a way out of all that oppression and misery. Little thought will be given to those left on the outside.

This is exactly right, but it’s not the whole story. Middle-class American women turned their backs on those less fortunate not only because of selfishness and I-got-mine-ism, but also because life on the materialist hamster wheel is so utterly grueling and exhausting that it leaves you neither the time nor the energy required in order to comprehend the worthier cause, let alone contribute to it meaningfully.

More here.

Tuesday, February 28, 2017

GROWING UP POOR, WITH TRUMP ON TV

Amanda Rea in Literary Hub:

Fresh_Prince_NBC_11A lot of things didn’t reach the remote corner of Colorado where I grew up. Hummus, for instance, and artichokes, mailmen, punk rock, paved roads. This was the mid 80s, so the internet wouldn’t exist for another few years, and our single TV channel played, in my memory, a near-continuous loop of The Cosby Show, broken now and then by an old episode of I Love Lucy. Airplanes passed over us, leaving white skid marks across the sky. Any passenger looking down would’ve seen nothing, a flat beige expanse where the Rocky Mountains petered out.

And yet, even there at the edge of a ghosted mining town, where jackrabbits outnumbered humans ten-to-one, we had heard of Donald Trump. His was a household name, synonymous with wealth and arrogance and a place called New York City, which might as well have been a settlement on the moon for all it meant to us. Between Cosbyreruns, Trump was on the news, wearing a suit, talking about his money. He was young then, early forties, and though his feathered ducktail hadn’t yet turned lurid yellow, he had the same petulant mouth and smug manner we know so well today. Newscasters fawned over him. They said he had the “Midas touch”—his father had given him a fortune, and he’d turned it into more fortune.

My brother and I rolled our eyes. Nobody had to tell us Trump was an asshole, though our parents probably muttered something to that effect. We were no big fans of rich people. Our family had always been poor—generations of miners, ranchers, farmers, and oil hands.

More here.

Does Dark Energy Mean We’re Losing Information About The Universe?

Ethan Siegel in Forbes:

ScreenHunter_2612 Feb. 28 18.28Perhaps the biggest surprise of all about the Universe came at the very end of the 20th century: the discovery of dark energy and the accelerated expansion of the Universe. Rather than being pulled towards us gravitationally, the most distant galaxies in the Universe are speeding away from us at ever faster-and-faster speeds, destined to disappear from our view. But does that create its own information paradox? Rob Hansen wants to know, and inquires:

The universe's expansion means our visible horizon is retreating; things faraway are vanishing continuously. (Albeit slowly, right now.) This would seem to imply we are losing information about the universe. So why is it the idea of losing information in a black hole's event horizon is so controversial, if we're constantly losing information to another horizon?

There's a lot to unpack here, so let's start with the accelerated expansion of the Universe.

More here.

The case for moral disengagement from politics in the age of Trump

Anis Shivani in Salon:

America-fuck-620x412There continues to be a gross underestimation, even among politically aware liberals, of what we are really up against, and how to counter it. Increasingly, our fellow citizens are resorting to the concepts of fascism to describe the current situation, but this is not necessarily followed by any cogent reflection on what the political subject under fascism needs to do. Ordinary liberal prescriptions have no chance of success under a regime that has moved into an overt fascist mode; moreover, the unacknowledged continuities from the recent neoliberal past, which led to the fascist overture in the first place, mar any consistency of thought among intellectuals, activists and ordinary citizens.

The time has come to explore modes of existence that only make sense under a fascist regime, or rather, are the only modes that make sense under fascist conditions. Above all, the question of moral disengagement from any existing political practice must be taken seriously, and this includes so-called “resistance.” Are there things that pass under the activist rubric today that are actually strengthening fascism rather than weakening it? If that is the case, then those activities must undergo severe scrutiny, because it may well be that what seems like activism is actually “passivism,” and vice versa.

More here.

Black Genealogies of Power: Seven Maxims for Resistance in the Trump Years

Dan Berger in AAIHS:

Mural_Malcolm_X_-_Ella_Baker_-_Martin_Luther_King_-_Frederick_Douglass-1024x823“Power concedes nothing without demand,” argued Frederick Douglass in one of his most cited speeches. “It never did and it never will.” Donald Trump inaugurated his first Black History Month at the White House with a bizarre mention of Douglass that made clear he does not know who Douglass was, what he did, or that the legendary abolitionist died 122 years ago. While Trump’s ignorance is clear, Douglass’s words remain a prescient example of how the black freedom struggle has thought about power. The black freedom struggle knows power intimately, as it has needed to: both the effects of power from above and the experience of power from below. How can it be otherwise? Slavery, colonialism, segregation, policing, and other forms of racism are power in and over the flesh. At the same time, black radicalism has developed its own power through abolitionism, marronage, transnationalism, feminism, labor organizing, fugitivity, and other forms of communal struggle.

Black History Month occasions a return to how black radicalism conceptualizes the issue of power. A diasporic political tradition built over centuries, the black radical tradition resists simplistic notions of what power is and how it operates. It has displayed a concurrent attention to strength on the bottom and to weakness from above. Here I want to complement the efforts of contemporary organizations such as BYP100, the Black Alliance for Just Immigration, the Dream Defenders, the Malcolm X Grassroots Movement, and the Movement for Black Lives by anchoring some of their historical forerunners. To that end, I present seven maxims of power as a useful but by no means comprehensive list for thinking about the revanchist assaults now underway by the Trump administration as well as the historic opposition movements now gathering force nationwide.

Don’t look to the institutions of power to resolve the problems caused by power. “O, let America be America again—/ The land that never has been yet—/ And yet must be—the land where every man [sic] is free,” Langston Hughes offered in his poem “Let America Be America Again.” Hughes’s poem centers on the contradiction of demanding “America be America again” with the recognition that “America never was America to me.” There are no halcyon days to return to, no golden era when American institutions upheld universal, intersectional antiracist policies. They have been, and remain, venues for necessary fights—both to defend existing rights and win new ones. Yet such fights are not calls to return to the past, to “restore faith” in traditional institutions, as we so often hear amidst Trumpist attacks on the media, the judiciary, and other normative branches of liberal democracy. Rather, political battles are most effective when pointing to the world that could be rather than the world that was (but wasn’t really).

More here. (Note: At least one post throughout February will be in honor of Black History Month)

In ‘Exit West,’ Mohsin Hamid Mixes Global Trouble With a Bit of Magic

Michiko Kakutani in The New York Times:

HamidMohsin Hamid’s dynamic yet lapidary books have all explored the convulsive changes overtaking the world, as tradition and modernity clash headlong, and as refugees — fleeing war or poverty or hopelessness — try to make their way to safer ground. His compelling new novel, “Exit West,” is no exception, recounting the story of the migrants Saeed and Nadia, who leave an unnamed country in the midst of a civil war and journey to Greece, England and eventually the United States in an effort to invent new lives for themselves. The first half of their story is about how war warps everyday life; the second half, a tale of globalization and its discontents. Writing in spare, crystalline prose, Hamid conveys the experience of living in a city under siege with sharp, stabbing immediacy. He shows just how swiftly ordinary life — with all its banal rituals and routines — can morph into the defensive crouch of life in a war zone, with fears of truck bombs and sniper fire and armed soldiers at checkpoints becoming a daily reality, along with constant surveillance from drones and helicopters. He also captures how insidiously violence alters the calculus of daily life: how windows with beautiful views become a liability; how funerals become smaller, more rushed affairs because of fighting in the streets.

The fiercely independent Nadia is feverishly keen to find a way out of the besieged city, and she and her more introspective boyfriend, Saeed, soon find an agent, who, for a fee, promises to supply them with an exit plan. There have been rumors of magical doors that whisk people away to strange and distant lands, and the door that Saeed and Nadia enter transports them to a beach on the Greek island of Mykonos, where hundreds of other migrants are living in tents and lean-tos in a makeshift refugee camp. Later, the couple will try other doorways that take them to other countries, other continents. “It was said in those days,” Hamid writes, “that the passage was both like dying and like being born.”

More here.

The returns to societal capital

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Dietrich Vollrath over at his website [via Brad Delong]:

Brad DeLong had a recent post that contained a number of ideas regarding how we view redistribution in a market economy. I picked up on some comments he made towards the end of that post, in which he points out that much of our prosperity comes from a stock of societal capital that we unknowingly rely on every day. And because that societal capital is unseen and uncompensated, we are all in some way overpaid for what we do.

When he says societal capital, I think of it in two broad categories:

  1. Trust: I think this is much of what DeLong has in mind. We are lucky to be in the “trust” or “cooperate” equilibrium in our repeated game of exhanging goods and services. If you like, call it the “stag hunt” equilibrium Nick Rowe talks about. Regardless, we benefit from the decisions of our ancestors to play this equilibrium, so that it is the default. If you want to say this is due to some institutions, or culture, or pure luck, it doesn’t matter. We’ve found our way to the trust equilibrium, and benfit from that immensely.2.
  2. Scale: He doesn’t mention this explicitly, but I think it is as relevant as trust. Scale influences the potential profits from innovations, and so is crucial to growth. Bigger market, more profits, more incentives to innovate. But scale is not the same thing as trust, or institutions, or culture. If you doubt that, ask yourself why no firm is spending millions to get into New Zealand, paragon of free market institutions, but they are falling all over themselves to do business in China. Living in the US, or EU, or China, is to reap the benefits of living with scale.

The heart of DeLong’s point is that neither trust nor scale are things that are owned by any firm or individual. You could say that we inherited them from our ancestors, or you could say these are emergent properties, or you could say that they are designed by the institutions we choose for ourselves. Regardless, trust and scale are “ideas” in the broadest sense, and are inputs into the production process in that trust and scale mean our set of rival inputs (labor, capital) can produce more with them than without.

How is it that scale and trust mean we are overpaid?

More here.

Citizenship: A relic of European legal culture?

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Dieter Gosewinkel in Eurozine:

A state is “the corporate body of a settled people equipped with sovereign authority”, wrote the influential Austrian constitutional lawyer Georg Jellinek in 1900. The defining characteristics of statehood are accordingly sovereign state power, a titular state people and a delineated state territory. This model of clear demarcations was formulated at the highpoint of the emergence of nation states, when they were at the peak of their legitimacy, and continues to shape international law to this day. National borders and national citizenship define an interior and exterior through legal means and thereby determine inclusion and exclusion. However, the theoretical and ethical bases of this legal construction are beginning to seem increasingly flawed.

Two waves of globalisation have undermined – and continue to undermine – the spatial concept of an economically and politically self-contained state. Worldwide flows of information, economic activity, communication and above all migration contradict conventional understanding of national statehood based on static models, in which the population is tied to one location, cultures are nationally delimited, and borders are only crossed as an exception. Political practice drives these developments forwards. The freedom of movement within the united Europe – the dissolution of borders for communication, goods and travel – has shaped the continent’s de facto existence to such an extent that it determines how leading European politicians imagine Europe ought to be: border checks should no longer be possible because they can no longer be conducted in practice. Praxis creates a theory that, in turn, confirms praxis. The advance of universalist global ethics and the humanitarianism of human rights legitimise a global politics of morality. Against this, the boundaries of traditional nation states seem at best anachronistic and at worst theoretically simplistic and ethically illegitimate.

More here.

Tragedy and Philosophy

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Richard Marshall interviews Dennis Schmidt in 3:AM Magazine:

3:AM: You have written about the tension between tragedy and philosophy – German philosophy in particular. What is this tension?

DS: I would suggest that this tension is at the very root of the idea of philosophy that we have inherited in the West and that, until recently, has largely gone unchallenged. Over time, this tension was simply set aside as philosophy increasingly came to neglect the claims of art. But when philosophy as we now know it began Plato took the work of art, especially tragedies (and here Homer is included since Plato does not distinguish tragedy and epic as Aristotle will), as a sort of foil in his efforts to delineate this new way of speaking about the world called “philosophy.” A different stage or theatre was exposed – a theatre of ideas in the mind, not of actors on the stage – language and dialogue were still crucial to this new theatre, but even the residue of theatre that belonged to philosophical dialogue would very soon disappear. The birth of the essay, of the treatise, is coterminous with the essential exclusion of the work of art from philosophy. [As an aside, I would suggest that interviews, such as the one’s you conduct, are a gentle way of restoring something of the dialogue character of thinking to philosophy.] Part of the argument that I made in speaking of the German recovery of Greek tragedy as a philosophical problem is that this marks a genuinely new moment in the long history of philosophy and that this recovery of tragedy as a question opens up avenues for philosophy in general that have been closed off since the beginnings of philosophy.

Perhaps the most direct way to characterize this tension is to say that tragedy is the expression of a view of life as defined finally by an insurmountable contradiction (of a law of life at odds with itself), while philosophy will always aim at a sort of overcoming of contradiction (of the law of non-contradiction as the need of truth). There is, of course, more to be said. The form of presentation proper to tragedy is, as Aristotle notes, reliant upon language, meter, plot, spectacle, and stage. Tragedy needs to appeal to emotional life, to a feeling that perhaps cannot be conceptualized. Philosophy, on the other hand, is deeply distrustful of any turn to emotional life and it is equally suspicious of any language that does not abide by the rule of the concept, that is, by the demand for universalizability and consistency. The concept has long remained the mother tongue of philosophy and, at the same time, a tragedy that can be reduced to its concept does not merit the claim of being a work of art.

More here.

Monday, February 27, 2017

Perceptions

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Eileen Alice Soper (1905-1990). When Badgers Awake.

John Lister-Kaye, naturalist and wildlife writer, describes his experience with Soper in “Gods of the Morning”:

“As we approached the (badger) setts in the dusk she seemed to slough off her human-ness and transmogrify into something more than half wild. I couldn't understand how she sat so still. She denied cold and rain, she ignored itches – a gnat landing on her nose – she seemed to become part of the wood herself, part of the tree, the soil, the still evening air …”

More here, and here.

Special note to my siblings: Eileen Soper was the illustrator of our beloved childhood books by Enid Blyton – look!

Sunday, February 26, 2017

Is Consciousness an Illusion?

Thomas Nagel in the New York Review of Books:

ScreenHunter_2608 Feb. 26 20.52For fifty years the philosopher Daniel Dennett has been engaged in a grand project of disenchantment of the human world, using science to free us from what he deems illusions—illusions that are difficult to dislodge because they are so natural. In From Bacteria to Bach and Back, his eighteenth book (thirteenth as sole author), Dennett presents a valuable and typically lucid synthesis of his worldview. Though it is supported by reams of scientific data, he acknowledges that much of what he says is conjectural rather than proven, either empirically or philosophically.

Dennett is always good company. He has a gargantuan appetite for scientific knowledge, and is one of the best people I know at transmitting it and explaining its significance, clearly and without superficiality. He writes with wit and elegance; and in this book especially, though it is frankly partisan, he tries hard to grasp and defuse the sources of resistance to his point of view. He recognizes that some of what he asks us to believe is strongly counterintuitive. I shall explain eventually why I think the overall project cannot succeed, but first let me set out the argument, which contains much that is true and insightful.

More here.

Against Willpower

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Carl Erik Fisher in Nautilus:

Thomas was a highly successful and mild-mannered lawyer who was worried about his drinking. When he came to see me at my psychotherapy practice, his wine intake had crept up to six or seven glasses a night, and he was starting to hide it from his family and to feel the effects at work. We discussed treatment strategies and made an appointment to meet again. But when he returned two weeks later, he was despondent: His drinking was totally unchanged.

“I just couldn’t cut back. I guess I just don’t have the willpower.”

Another patient of mine, John, also initially came to me for help with drinking. At our first meeting, we talked about moderation-based approaches and setting a healthier limit. But one month later, he came back to my office declaring that he had changed his mind and made peace with his drinking habits. Sure, his wife wasn’t always thrilled with how much he drank, he told me, and occasionally the hangovers were pretty bad, but his relationship was still fairly solid and drinking didn’t cause any truly significant problems in his life.

In the abstract, John and Thomas are similar: They both succumbed to short-term temptations, and both didn’t keep their long-term goals. But while Thomas attributed that outcome to problems with willpower, John came to reframe his behavior from a perspective that sidestepped the concept of willpower altogether. Both John and Thomas would resolve their issues, but in very different ways.

Most people feel more comfortable with Thomas’ narrative. They would agree with his self-diagnosis (that he lacked willpower), and might even call it clear-eyed and courageous. Many people might also suspect that John’s reframing of his problem was an act of self-deception, serving to hide a real problem. But Thomas’ approach deserves just as much skepticism as John’s. It’s entirely possible that Thomas was seduced by the near-mystical status that modern culture has assigned to the idea of willpower itself—an idea that, ultimately, was working against him.

The Future of Not Working

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Annie Lowery in the NYT Magazine:

The basic or guaranteed income is a curious piece of intellectual flotsam that has washed ashore several times in the past half-millennium, often during periods of great economic upheaval. In “Utopia,” published in 1516, Thomas More suggests it as a way to help feudal farmers hurt by the conversion of common land for public use into private land for commercial use. In “Agrarian Justice,” published in 1797, Thomas Paine supports it for similar reasons, as compensation for the “loss of his or her natural inheritance, by the introduction of the system of landed property.” It reappears in the writings of French radicals, of Bertrand Russell, of the Rev. Dr. Martin Luther King Jr.

Silicon Valley has recently become obsessed with basic income for reasons simultaneously generous and self-interested, as a palliative for the societal turbulence its inventions might unleash. Many technologists believe we are living at the precipice of an artificial-intelligence revolution that could vault humanity into a postwork future. In the past few years, artificially intelligent systems have become proficient at a startling number of tasks, from reading cancer scans to piloting a car to summarizing a sports game to translating prose. Any job that can be broken down into discrete, repeatable tasks — financial analytics, marketing, legal work — could be automated out of existence.

In this vision of the future, our economy could turn into a funhouse-mirror version of itself: extreme income and wealth inequality, rising poverty, mass unemployment, a shrinking prime-age labor force. It would be more George Saunders than George Jetson. But what does this all have to do with a small village in Kenya?

A universal basic income has thus far lacked what tech folks might call a proof of concept. There have been a handful of experiments, including ones in Canada, India and Namibia. Finland is sending money to unemployed people, and the Dutch city Utrecht is doing a trial run, too. But no experiment has been truly complete, studying what happens when you give a whole community money for an extended period of time — when nobody has to worry where his or her next meal is coming from or fear the loss of a job or the birth of a child.

And so, the tech industry is getting behind GiveDirectly and other organizations testing the idea out.

More here.