The World in 2025

Peter Diamandis in Singularity Hub:

Existing healthcare institutions will be crushed as new business models with better and more efficient care emerge. Thousands of startups, as well as today’s data giants (Google, Apple, Microsoft, SAP, IBM, etc.) will all enter this lucrative $3.8 trillion healthcare industry with new business models that dematerialize, demonetize and democratize today’s bureaucratic and inefficient system.

Biometric sensing (wearables) and AI will make each of us the CEOs of our own health. Large-scale genomic sequencing and machine learning will allow us to understand the root cause of cancer, heart disease and neurodegenerative disease and what to do about it. Robotic surgeons can carry out an autonomous surgical procedure perfectly (every time) for pennies on the dollar. Each of us will be able to regrow a heart, liver, lung or kidney when we need it, instead of waiting for the donor to die.

More here.

The Double Life of George Eliot

Mollie Wilson O’Reilly at Commonweal:

In discussing Eliot’s work, it is tempting to pass over the messy details of her private life in delicate embarrassment. (That late-in-life marriage to John Cross, for example, is truly weird.) But Clare Carlisle’s excellent new book The Marriage Question dares to take Eliot’s personal life seriously, as the field in which her finest work was cultivated. And, coming at the end of Carlisle’s empathetic portrait of the woman who called herself Mrs. Lewes, a woman who crowned each of her manuscripts with a sincere dedication to her beloved “husband,” Huxley’s verdict on Eliot’s life lands as an outrageous insult. He had been asked to support her interment in the Abbey, but replied with his reasons for opposing it. “One cannot eat one’s cake and have it too,” he sniffed. “Those who elect to be free in thought and deed must not hanker after the rewards, if they are to be so called, which the world offers to those who put up with its fetters.”

Could any woman hope to be “free in thought and deed” in 1850s England?

more here.

The Forgotten Essays of Louisa May Alcott

Liz Rosenberg at Lit Hub:

Her essays are rich with unerasable moments, and as in her greatest works of fiction, they strike the intersecting point between tragedy and comedy. If she tugs on heart-strings in her essays—and most assuredly she does—she also demonstrates a clear awareness of the funny side of life.

Alcott understood that habitual use of humor and exaggeration might incline readers to doubt the veracity of her non-fiction.  At the end of Hospital Sketches she urges the reader to believe what is only partly true: “such a being as Nurse Periwinkle does exist, that she really did go to Washington, and…these Sketches are not romance.” Her fiction found its roots in real-life experiences and her non-fiction always contained kernels of invention.  She largely shrugged off strict distinctions between fact and fiction.

more here.

Insights from Western literature and myth point to the ethical problem at the core of human intelligence

Richard van Oort at Scroll.in:

Each day brings a reminder of another threat to our peace and security. War, political instability and climate change send migrants and refugees across national borders. Cybercriminals hack networks of public and private institutions. Terrorists use trucks and planes as weapons.

And hanging grimly above us all, like the sword of Damocles, lurks the threat of total nuclear annihilation.

At the root of these threats is a problem that is as old as humanity itself.

In the domain of survival and reproduction, human intelligence stands out for one specific reason. We are the only species on earth for whom intelligence is also an ethical liability. As the anthropological critic Eric Gans has argued, we are the only species for whom the problem of our violence is also our greatest existential threat.

Insights from Western literature and myth point to the ethical problem at the core of human intelligence.

More here.

‘Mind-blowing’ IBM chip speeds up AI

Davide Castelvecchi in Nature:

A brain-inspired computer chip that could supercharge artificial intelligence (AI) by working faster with much less power has been developed by researchers at IBM in San Jose, California. Their massive NorthPole processor chip eliminates the need to frequently access external memory, and so performs tasks such as image recognition faster than existing architectures do — while consuming vastly less power.

“Its energy efficiency is just mind-blowing,” says Damien Querlioz, a nanoelectronics researcher at the University of Paris-Saclay in Palaiseau. The work, published in Science1, shows that computing and memory can be integrated on a large scale, he says. “I feel the paper will shake the common thinking in computer architecture.”

NorthPole runs neural networks: multi-layered arrays of simple computational units programmed to recognize patterns in data. A bottom layer takes in data, such as the pixels in an image; each successive layer detects patterns of increasing complexity and passes information on to the next layer. The top layer produces an output that, for example, can express how likely an image is to contain a cat, a car or other objects.

More here.

The Chief Ideologist of the Silicon Valley Elite Has Some Strange Ideas

Ezra Klein in the New York Times:

Marc Andreessen

We are used to thinking of our ideological divide as cleaving conservatives from liberals. I think the Republican Party’s collapse into incoherence reflects the fact that much of the modern right is reactionary, not conservative. This is what connects figures as disparate as Jordan Peterson and J.D. Vance and Peter Thiel and Donald Trump. These are the ideas that unite both the mainstream and the weirder figures of the so-called postliberal right, from Patrick Deneen to the writer Bronze Age Pervert. This is not a coalition that cares about tax cuts. It’s a coalition obsessed with where we went wrong: the weakness, the political correctness, the liberalism, the trigger warnings, the smug elites. It’s a coalition that believes we were once hard and have become soft; worse, we have come to lionize softness and punish hardness.

More here.

Travis Gienger’s massive, record-breaking pumpkin took nearly three decades of blood, sweat, and tears to create

From Slate:

I grew up around pumpkins. My dad grew big ones that were 80- or 100-pounders, and I always thought it was neat. Every kid loves pumpkins. We would also go to the state fair and see the giant pumpkins there, and I thought, “That’s kind of cool. I want to grow one.” When I was 14, I grew a 470-pounder. That was three decades ago, and I’ve been growing pumpkins ever since. I’m just now starting to get the hang of it. I didn’t even win a contest until 2020, but that year, I set the North American record with a 2,350-pound pumpkin.

It’s all about figuring out the right recipe. This year, I started in mid-April, with my plants indoors because it’s easier to control the temperatures and germination. I started with two seeds, hoping that I’d get two pumpkins—you start with two to increase your chances of success. Hopefully, you have two at the end, but it doesn’t always work out that way. After the seeds germinated, I transferred them outside to a little hoop house in my backyard, right out my bedroom window, so I could be right there as they grew. They had good soil, heating, cables, and grow lights. I spent two or three hours a day with them. My friends thought I was nuts, especially because I skipped the opening day of fishing to take care of a giant pumpkin.

More here.

Extracellular Events Involved in Cancer Cell–Cell Fusion

Dittmar and Hass in Int J Mol Sci:

Fusion among different cell populations represents a rare process that is mediated by both intrinsic and extracellular events. Cellular hybrid formation is relayed by orchestrating tightly regulated signaling pathways that can involve both normal and neoplastic cells. Certain important cell merger processes are often required during distinct organismal and tissue development, including placenta and skeletal muscle. In a neoplastic environment, however, cancer cell fusion can generate new cancer hybrid cells.

Following survival during a subsequent post-hybrid selection process (PHSP), the new cancer hybrid cells express different tumorigenic properties. These can include elevated proliferative capacity, increased metastatic potential, resistance to certain therapeutic compounds, and formation of cancer stem-like cells, all of which characterize significantly enhanced tumor plasticity. However, many parts within this multi-step cascade are still poorly understood. Aside from intrinsic factors, cell fusion is particularly affected by extracellular conditions, including an inflammatory microenvironment, viruses, pH and ionic stress, hypoxia, and exosome signaling.

More here.

Friday Poem

Poem

and greenhouse and topsoil and basil greens
and cowshit and snowfall and spinach knife
and woodsmoke and watering can and common thistle

and potato digger and peach trees
and poison parsnip and romaine hearts
and rockpiles and spring trilliums and ramp circles

what song of grassblade
what creak of dark rustle tree
and blueblack wind from the north

this vetch this grapevine
this waterhose this mosspatch

sunflower gardens in the lowland
dog graves between the apple trees

this fistfull of onion tops
this garlic laid silent in the barn
this green this green this green

sweet cucumber leaf
sweet yellow bean

and all this I try to make a human shape
the darkness regenerating a shadow of a limb

my tongue embraces the snap pea
and so it is sweet

how does the rusted golfcart in the chickweed
inform my daily breath

I’m sorry I want to say
to the unhearing spaces
between the dogwood trees

for my tiny little life
I have pressed into
your bruising green skin

by Lucy Walker
from
  Pank Magazine

The Essential Vladimir Nabokov

Molly Young in the New York Times:

People who dislike Vladimir Nabokov tend to find his dexterity stressful, like watching a circus performer juggle torches for hours. The solution to this is to chill out. It’s not your job to worry that an elective juggler is going to light his shorts on fire! Let the performer assess his own risks!

A more pragmatic solution for skeptics is to administer Nabokov in modest doses, a page or two at a time, before working up to full chapters. Even with tiny bites you’ll immediately perceive the way he hops between material realms and metaphysical ones as freely as a bunny in a meadow. You’ll notice the way synesthesia guides his pen, and you’ll pick up his themes of exile, wonder, the afterlife and the privacy and primacy of marriage.

More here.

Inflammation in severe COVID linked to bad fungal microbiome

McKenzie Prillaman in Nature:

An imbalance of fungi in the gut could contribute to excessive inflammation in people with severe COVID-19 or long COVID. A study found that individuals with severe disease had elevated levels of a fungus that can activate the immune system and induce long-lasting changes.

The work, published on 23 October in Nature Immunology1, raises the possibility that antifungal treatment could provide some relief to people who are critically ill with COVID-19.

“We know inflammation is driving severe disease,” says Martin Hönigl, a clinical mycology researcher at the Medical University of Graz in Austria, who was not involved in the study. This work, he says, provides a potential mechanism of disease-causing inflammation that might have been overlooked.

More here.

Letter from Israel

Oded Na’aman in the Boston Review:

It is now 1 p.m., Wednesday, October 18, and I am at home, in Tel Aviv. Eleven days have passed since the October 7 attack on Israel. At least 1,400 people were killed in one day, mostly civilians, and there are around 200 Israeli hostages held in the Gaza Strip. Israel has since launched its deadliest attack on Gaza so far: around 3,500 Gazans have been killed, about 1,000 of them children. Hamas still manages to fire rockets at Israel, mostly toward towns closer to Gaza, but some toward Tel Aviv. Every evening, between 7 and 9 p.m., sirens go off and we run to find shelter. During the day we can sometimes hear unidentified explosions in the distance. There are many ambulances and police sirens; helicopters and fighter jets pass overhead, and there’s a constant sound of drones hovering over the city, to what purpose we do not know. Most stores are closed shut. Many restaurants and cafés have been transformed into supply centers from which food and equipment are delivered by volunteers across the country to soldiers, to survivors of the attack, and to residents from towns that have been evacuated. At night, a few bars open. They are half empty, the patrons drink and speak softly. In normal days, the city is packed and vibrant till late into the night. Around midnight, I go out to the balcony or take a stroll in the vacant streets. Everywhere the quiet is breathless.

In this land, nothing is very far. A leisurely drive from Tel Aviv to Gaza City, if it were possible, would take about one hour. By the end of this week, in the span of fourteen days, a total of 5,000 people—Israeli and Palestinian—will have died, many more lives will have been ruined beyond repair, horror, panic and hatred will have been instilled in masses of people, not only here, in this small land, but across the globe. Darkness behind us, darkness ahead.

More here.

How Seawater’s Teeming Life May Change Our Own

Nathan Gardels and Craig Venter at Noema:

Nathan Gardels: Generative AI has been heralded lately as one of the great game-changing innovations of our time. I remember in one of our conversations years ago when you said already then that biology was becoming a computational science, opening a path to the “dawn of digital life.”  What is the impact of the ever-more empowered big data processing of AI, particularly generative AI, on genomics and the potential of synthetic biology?

Craig Venter: So far, one of the greatest impacts of the use of generative AI has been in improving protein structure predictions, or 3D modeling of gene sequences. That is a big deal because it allows us to understand many of the genes with unknown functions that provide the various chemical signals that determine the growth, differentiation, and development of cells. As far as anybody can tell, the predictions coming out of generative AI seem to be a big improvement over existing algorithms. In 2016 we announced the first synthetic “minimal cell,” a self-replicating organism, a bacterial genome that encoded only the minimal set of genes necessary for the cell to survive. But even at that quite minimal level we still did not know the functions of up to 25% of those genes.

more here.

‘The Pole and Other Stories’ By J M Coetzee

James Purdon at Literary Review:

Having appeared last year as a standalone novel in a Spanish translation by Mariana Dimópoulos, ‘The Pole’ continues Coetzee’s recent preference for publishing first in languages other than English, as do three more of the six stories collected here (the two exceptions are the Elizabeth Costello story ‘As a Woman Grows Older’ and the brief concluding tale ‘The Dog’, a minimalist piece that amplifies a theme from 1999’s Disgrace). Late in life, Coetzee has emerged as a self-consciously global novelist, whose disquiet at the dominance of the English language in which he writes has profoundly affected the ethical as well as the aesthetic dimensions of his fiction. Appropriately, then, ‘The Pole’ is a story about the difficulties of communicating across the barriers between languages, sexes, generations – and across the hard gap that divides the dead from the living. It’s also a story about legacies, both personal and literary, and Coetzee alludes liberally to his own earlier work as well as that of other writers. The elegant, self-regarding Beatriz seems a distant relation not only of her namesake in Dante (another banker’s wife), but also of those society women who, in T S Eliot’s ‘Portrait of a Lady’, flock ‘to hear the latest Pole/Transmit the Preludes, through his hair and finger-tips’.

more here.

Thursday Poem

Our Own Blood

The generals deliberate on the climate of war,
insulted that some harebrained foreigners
might beat them at seizing the capital.

The generals read barometers of insiders,
tally missiles and unmanned drones.
Their temperatures escalate as the budget deficit
dives and the foreigners move forward.

The Supreme Commanders would like nothing better
than to turn the tide, reduce the expense of casualties
to zero, risk only what’s necessary,
leave nothing to accident.

Fingers like rolls of million-dollar bills
toying with the buttons of boom,
the generals reckon lives,
plot exact targets via satellite surveillance.

The security of our native land hovers
like Apache helicopters
on a do-or-die sortie.

The generals know it has always been
us or the enemy, the battle between
alien blood and our own.

by Bruce Lader
from The New York Quarterly

A Symbol for The Anthropocene: Our love affair with the chair

Vybarr Cregan-Reid in Anthropocene:

Why are there no chairs in the King James Bible, or in all 30,000 lines of Homer? Neither are there any in Shakespeare’s Hamlet—written in 1599. But by the middle of the nineteenth century, it is a completely different story. Charles Dickens’s Bleak House suddenly has 187 of them. What changed? With sitting being called “the new smoking,” we all know that spending too much time in chairs is bad for us. Not only are they unhealthy, but like air pollution, they are becoming almost impossible for modern humans to avoid.

When I started researching my book about how the world we have made is changing our bodies, I was surprised to discover just how rare chairs used to be. Now they’re everywhere: offices, trains, cafés, restaurants, pubs, cars, trains, concert halls, cinemas, doctors’ surgeries, hospitals, theaters, schools, university lecture halls, and all over our houses. (I guarantee you have more than you think.)

More here.