Samira Asgari and Lionel A. Pousaz in Nature:
For more than a year now, scientists and clinicians have been trying to understand why some people develop severe COVID-19 whereas others barely show any symptoms. Risk factors such as age and underlying medical conditions1, and environmental factors including socio-economic determinants of health2, are known to have roles in determining disease severity. However, variations in the human genome are a less-investigated source of variability. Writing in Nature, members of the COVID-19 Host Genetics Initiative3 (www.covid19hg.org) report results of a large human genetic study of SARS-CoV-2 infection. The researchers identify 13 locations (or loci) in the human genome that affect COVID-19 susceptibility and severity.