Sean Carroll in Preposterous Universe:
Cosmological models that invoke a multiverse – a collection of unobservable regions of space where conditions are very different from the region around us – are controversial, on the grounds that unobservable phenomena shouldn’t play a crucial role in legitimate scientific theories. I argue that the way we evaluate multiverse models is precisely the same as the way we evaluate any other models, on the basis of abduction, Bayesian inference, and empirical success. There is no scientifically respectable way to do cosmology without taking into account different possibilities for what the universe might be like outside our horizon. Multiverse theories are utterly conventionally scientific, even if evaluating them can be difficult in practice.
This is well-trodden ground, of course. We’re talking about the cosmological multiverse, not its very different relative the Many-Worlds interpretation of quantum mechanics. It’s not the best name, as the idea is that there is only one “universe,” in the sense of a connected region of space, but of course in an expanding universe there will be a horizon past which it is impossible to see. If conditions in far-away unobservable regions are very different from conditions nearby, we call the collection of all such regions “the multiverse.”
There are legitimate scientific puzzles raised by the multiverse idea, but there are also fake problems. Among the fakes is the idea that “the multiverse isn’t science because it’s unobservable and therefore unfalsifiable.” I’ve written about this before, but shockingly not everyone immediately agreed with everything I have said.
Back in 2014 the Edge Annual Question was “What Scientific Theory Is Ready for Retirement?”, and I answered Falsifiability. The idea of falsifiability, pioneered by philosopher Karl Popper and adopted as a bumper-sticker slogan by some working scientists, is that a theory only counts as “science” if we can envision an experiment that could potentially return an answer that was utterly incompatible with the theory, thereby consigning it to the scientific dustbin. Popper’s idea was to rule out so-called theories that were so fuzzy and ill-defined that they were compatible with literally anything.