From CNN:
Randy Pausch, the professor whose “last lecture” became a runaway phenomenon on the Internet and was turned into a best-selling book, died Friday of pancreatic cancer, Carnegie Mellon University announced on its Web site.
Pausch, 47, a computer science professor, delivered the lecture, “Really Achieving Your Childhood Dreams,” at Carnegie Mellon in September 2007, a month after being told he had three to six months to live because his cancer had returned.
More here. And do take an hour and a quarter to watch this video of the moving lecture: